BRCA1 Gene News and Research

RSS

BRCA1 is a gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA1 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.

New research may help identify patients most likely to benefit from cisplatin treatment

Researchers at the Massachusetts General Hospital (MGH) Cancer Center have identified a subgroup of hard-to-treat breast cancers that may be sensitive to the drug cisplatin, rarely used in the treatment of breast tumors.

20 Apr 2007

Cancer genetic risk assessment for individuals at risk of familial breast cancer

Since recent medical findings have revealed that some families have increased breast cancer risk, a number of people are turning to cancer genetic services to learn more.

19 Apr 2007

New discoveries about stem cells in leukemia, breast and colon cancer

Recent discoveries about the role of stem cells in cancer have altered the landscape of cancer research. With each new study, scientists are learning more about cancer-initiating properties of stem cells at organ sites and throughout the body.

19 Apr 2007

Health disparities in access to healthcare

Minority individuals are much more likely to develop and die from cancer than the general U.S. population.

16 Apr 2007

More women with family breast cancer history inquiring about MRI screening following ACS guidelines

More women with a family history of breast cancer are asking their physicians whether they should undergo breast magnetic resonance imaging scans after American Cancer Society guidelines released on Wednesday recommended the screening for women at high risk of developing the disease, the Baltimore Sun reports.

2 Apr 2007

Survey finds perceived risk of recurrence is low in African American breast cancer survivors

A unique survey of African American breast cancer survivors at heightened risk for hereditary breast cancer has found the majority do not believe they have an increased chance of developing the cancer again.

15 Feb 2007

Variation in gene caspase-8 may help protect against breast cancer

A large-scale analysis of data on breast cancer risk has concluded that a common variation in the gene caspase-8 (CASP8) is associated with a somewhat lower risk of the disease. Variants are small changes that occur in a gene sequence.

13 Feb 2007

PALB2 gene mutation elevates risk of breast cancer four-fold

Cancer is a complex and common disease caused by a combination of both genetic and environmental factors. An inherited predisposition seems to be involved in at least 5-10 per cent of all cases of breast cancer.

11 Feb 2007

Selective marker found to indicate aggressive form of breast cancer

Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment.

16 Jan 2007

Mifepristone offers hope for breast cancer victims

A team of scientists have discovered some unexpected benefits with the abortion pill RU486 (Mifepristone).

4 Dec 2006

Vitamin D may slow down breast cancer

The authors of a new study are suggesting that vitamin D may slow down the progression of breast cancer.

17 Oct 2006

Breast and ovarian cancers linked by heredity - women need to know their risks

During September, Gynecologic Cancer Awareness Month, the Gynecologic Cancer Foundation (GCF) urges women to learn more about familial breast-ovarian cancer syndrome.

12 Sep 2006

Validation of a tool for identifying women at high risk for hereditary breast cancer

A new screening tool for the general practitioner effectively identifies patients at risk for hereditary breast cancer, according to a new study.

11 Sep 2006

Findings shed new light on BRCA1 and BRCA2 breast-cancer gene mutations in older and African-American women

Clearest picture yet of the prevalence and predictors of mutations in the breast-cancer susceptibility genes BRCA1 and BRCA2 among women in the general population.

15 Aug 2006

Gene amplification links growth controlling pathway from Drosophila to human cancers

Researchers at Harvard Medical School (HMS) and Massachusetts General Hospital (MGH) have discovered a new cancer-promoting role for a gene potentially involved in breast, liver, and other kinds of cancers.

8 Aug 2006

Variation in the CHEK2 gene may triple a woman's risk of developing breast cancer

Study shows that women in the general population who carry a specific CHEK2 mutation are three times as likely as women without the mutation to develop breast cancer.

2 Aug 2006

Basal tumours may originate from breast stem cells that have undergone genetic mishaps

Findings support previous speculation that breast stem cells, or very early descendents, are the cells from which basal tumours arise.

24 Jul 2006

New role discovered for breast cancer susceptibility gene BRCA1

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression.

18 Jul 2006

Women with mutations in BRCA1 or BRCA2 genes can reduce cancer risk by having ovaries removed

Women with mutations in the BRCA1 or BRCA2 genes can significantly reduce their risk of certain types of cancer by having their ovaries removed, according to a study in the July 12 issue of Journal of the American Medical Association.

12 Jul 2006

Scientists unravel breast cancer risk gene mystery

The risk of developing breast cancer is doubled in women who inherit a damaged version of a gene called ATM, according to a study published by Cancer Research UK funded scientists and collaborators in Nature Genetics.

10 Jul 2006