BRCA2 Gene News and Research

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BRCA2 is a gene on chromosome 13 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA2 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.

Risk of breast cancer mutations underestimated for Asian women, Stanford study shows

Oncologist Allison Kurian, MD, and her colleagues at the Stanford University School of Medicine were perplexed. Computer models designed to identify women who might have dangerous genetic mutations that increase their risk of breast and ovarian cancer worked well for white women. But they seemed to be less reliable for another ethnic group.

11 Sep 2008

New method to evaluate variations identified in breast cancer susceptibility genes

Using mouse embryonic stem cells, researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have developed a new method to evaluate which mutations, or changes, in a gene known to increase breast cancer susceptibility, may lead to cancer. The new test, called a functional assay, is more comprehensive and reliable than most current methods.

7 Jul 2008

Genetic profiling for breast cancer on the horizon

Cancer Research UK scientists have shown that it may soon be possible to offer women a genetic test to assess their risk of breast cancer which could aid early diagnosis for those at high risk of the disease. Their findings are revealed in the New England Journal of Medicine today (Wednesday).

26 Jun 2008

Prostate cancer deaths double in men with BRCA2

Men with prostate cancer caused by a faulty BRCA2 gene are more than twice as likely to die from the disease than those carrying the faulty BRCA1 gene - reveals a study published in the British Journal of Cancer today (Tuesday).

25 Jun 2008

Breast cancer gene a culprit in prostate cancer

Australian researchers have discovered that a mutated version of the BRCA-2 gene known to lead to breast and ovarian cancer, is also a culprit in prostate cancer in men.

20 May 2008

MRI's high false positive rate has little impact on women's choice of preventive mastectomy

Magnetic resonance imaging (MRI) falsely detects breast cancer in five out of every six positive scans according to new research into the use of MRI for women with a high, inherited risk of developing the disease.

26 Mar 2008

Breast cancer gene carriers' risk 'amplified' by additional genes

Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra 'risk amplifying' genes, according to research published in the American Journal of Human Genetics today.

24 Mar 2008

New study confirms that PROGENSA PCA3 can improve accuracy of prostate cancer diagnosis

New clinical data from a study of 570 men published in the peer-reviewed Journal of Urology support the use of PROGENSA PCA3 as a tool for diagnosing prostate cancer. The study confirms that PROGENSA PCA3, the world's first gene-based urine test to help detect prostate cancer, can provide clinicians with valuable information that helps guide diagnosis.

20 Mar 2008

New drug trial to target hereditary cancers

Cancer Research UK scientists at Newcastle University are starting the first UK trial of a new drug which targets the 'Achilles' heel' in hereditary forms of both breast and ovarian cancer.

28 Feb 2008

New drug trial to target hereditary cancers

Cancer Research UK scientists at Newcastle University are starting the first UK trial of a new drug which targets the 'Achilles' heel' in hereditary forms of both breast and ovarian cancer.

28 Feb 2008

Personalized medicine can cut breast cancer risk

The time has come for breast cancer risk assessment, counseling and genetic testing to move from cancer specialists to the realm of primary care, according to a presentation at the AAAS annual meeting, held this year in Boston.

17 Feb 2008

Scientists discover why some breast cancers are drug resistant

Research by British scientists has revealed how cancer cells which have a faulty gene can become resistant to treatment.

13 Feb 2008

Benefit of removal of the ovaries differs between women with BRCA1 and BRCA2 mutations

The surgical removal of the ovaries has been widely adopted as a cancer-risk-reducing strategy for women with either BRCA1 or BRCA2 mutations.

12 Feb 2008

Cancer cells adapt using Darwin's 'survival of the fittest' principle to resist treatment

Scientists in London have discovered a new genetic mechanism which helps cancer cells survive by changing the way they respond to treatment.

11 Feb 2008

BRCA1 and BRCA2 gene mutations and breast cancer

Breast cancer risk varies widely among women who are carriers of the BRCA1 and BRCA2 mutations, according to a new study published in the January 9, 2008, issue of the Journal of the American Medical Association (JAMA).

9 Jan 2008

Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene

Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations.

2 Jan 2008

Men unaware of their cancer risk when female relatives test positive for BRCA mutation

Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk.

17 Dec 2007

Most carriers of Fanconi anemia genes are not at a higher risk of cancer

For almost 50 years, Fanconi anemia has been associated with leukemia. Not just among those who have the genetic disorder but among their family members, whose genes, they were told, made them highly susceptible to a variety of malignancies.

13 Dec 2007

Study shows how mutations in the BRCA1 gene lead to breast cancer

An international team of researchers led by Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center and Sweden's Lund University has, for the first time, revealed how mutations in the BRCA1 gene lead to breast cancer.

10 Dec 2007

Network approach finds potential breast cancer susceptibility gene

Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.

10 Oct 2007

BRCA2 Gene News and Research

Further Reading

Risk of breast cancer mutations underestimated for Asian women, Stanford study shows

New method to evaluate variations identified in breast cancer susceptibility genes

Genetic profiling for breast cancer on the horizon

Prostate cancer deaths double in men with BRCA2

Breast cancer gene a culprit in prostate cancer

MRI's high false positive rate has little impact on women's choice of preventive mastectomy

Breast cancer gene carriers' risk 'amplified' by additional genes

New study confirms that PROGENSA PCA3 can improve accuracy of prostate cancer diagnosis

New drug trial to target hereditary cancers

New drug trial to target hereditary cancers

Personalized medicine can cut breast cancer risk

Scientists discover why some breast cancers are drug resistant

Benefit of removal of the ovaries differs between women with BRCA1 and BRCA2 mutations

Cancer cells adapt using Darwin's 'survival of the fittest' principle to resist treatment

BRCA1 and BRCA2 gene mutations and breast cancer

Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene

Men unaware of their cancer risk when female relatives test positive for BRCA mutation

Most carriers of Fanconi anemia genes are not at a higher risk of cancer

Study shows how mutations in the BRCA1 gene lead to breast cancer

Network approach finds potential breast cancer susceptibility gene

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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