Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission.
The impact of the COVID-19 pandemic on children with disabilities has not received much attention, perhaps because the disease disproportionately affects older individuals.
Scientists from Far Eastern Federal University together with leading international experts suggest reconsidering the existing treatment protocol for severe spasticity, one of the main complications after spinal cord injury with partial spinal cord disruption.
One in 25 patients with very low kidney function were admitted to hospital with severe confusion and other cognitive-related symptoms a few days after being prescribed a common muscle relaxant.
This case study of a patient with ALS and symptoms of cannabinoid hyperemesis syndrome emphasizes the need for research into the use of medicinal cannabis.
In an effort to reduce chronic pain, many people look for hope by paying $20 to thousands of dollars for a tube of prescription topical pain cream or gel.
A new study has shown that pain relief creams are no better than dummy or placebo creams when it comes to relieving pain.
Changes in a brain signaling system contribute to the development of alcohol addiction-like behaviors in rats, according to a new study led by researchers at Linköping University, Sweden.
Scientists have found that brain functions in young men and women are changed by long-term alcohol use, but that these changes are significantly different in men and women.
Chickenpox is a typical childhood illness. In most cases, it is benign, and the symptoms disappear within ten days. However, its causative agent, Varicella zoster virus (VZV), remains in the organism forever. In some cases, the virus can be reactivated years later, causing a different disease known as herpes zoster, or shingles.
Results revealed today at The International Liver Congress 2015, show that in patients with alcohol-induced liver disease (ALD), Baclofen has a positive impact on alcohol consumption and overall measures of liver function and harm.
Many patients suffer from severe spinal cord injuries after being involved in traffic accidents or accidents at work.
Alcoholic liver disease (ALD) is one of the leading causes of death worldwide and also in the UK. As its name indicates this disease arises due to consuming excessive amounts of alcohol (80 g/day) over an extended period, normally 10-20 years.
Neuroscientists at SRI International have found that a form of baclofen, a drug used to treat muscle spasticity, works better at treating narcolepsy than the best drug currently available when tested in mice.
Relapse is the most painful and expensive feature of drug addiction-even after addicted individuals have been drug-free for months or years, the likelihood of sliding back into the habit remains high. The National Institute on Drug Abuse estimates that 40 to 60 percent of addicted individuals will relapse, and in some studies the rates are as high as 80 percent at six months after treatment.
Gastroesophageal Reflux Disease (GERD) is a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
An estimated 1 in 5 U.S. adults suffer from Gastroesophageal Reflux Disease (GERD), a chronic, often progressive disease that can cause debilitating symptoms and in certain cases lead to esophageal cancer.
The Child Neurology Society presented Ann Henderson Tilton, MD, Clinical Professor of Neurology at LSU Health Sciences Center New Orleans, with the 2012 Hower Award at the 41st Annual CNS Meeting in November.
Codman & Shurtleff, Inc. (Codman), the global neurological device company, has received U.S. Food and Drug Administration (FDA) approval through a PMA supplement for its MEDSTREAM Programmable Infusion System, an implantable infusion pump and catheter system used in the treatment of spasticity, a movement disorder often caused by stroke, cerebral palsy, multiple sclerosis or spinal cord injury.
Lesogaberan is only marginally superior to placebo in gastroesophageal reflux disease patients who are partially responsive to proton pump inhibitor therapy, results show.
Scientists at The Scripps Research Institute have developed a powerful new technique for manipulating the building-block molecules of organic chemistry. The technique enables chemists to add new functional molecules to previously hard-to-reach positions on existing compounds-making it easier for them to generate new drugs and other organic chemicals.