Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Studies show protein semaphorin 3A helps detect acute kidney injury

A guidance cue that helps kidneys form may also be a red flag that they are in danger, researchers report.

13 Mar 2013

New, inexpensive nano-biosensor can detect Listeria monocytogenes in food

The foodborne bacteria Listeria monocytogenes sickens about 2,500 people in the U.S. each year and many more worldwide, killing about 25-30% of those infected. Listeriosis is caused by eating food contaminated with L. monocytogenes, and current methods for detecting the bacteria are costly and time consuming.

13 Mar 2013

RELAX study finds no beneficial effects of erectile dysfunction drug for diastolic heart failure

Despite high expectations for a commonly used erectile dysfunction drug to treat patients with diastolic heart failure, no beneficial effects were found in a study presented today at the American College of Cardiology's 62nd Annual Scientific Session.

13 Mar 2013

MiR-198 controls migration of skin cells necessary for wounds to close and heal

Patients with diseases such as diabetes suffer from painful wounds that take a long time to heal making them more susceptible to infections that could even lead to amputations. A*STAR's discovery paves the way for therapeutics to improve healing of such chronic wounds, which are a significant burden to patients.

11 Mar 2013

New immunoassay appears to be valid screening method for early detection of renal cell carcinoma

A new immunoassay that tests for the presence of three biomarkers appears to be a valid screening method for the early detection of malignant kidney cancer, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

11 Mar 2013

Chronic obstructive pulmonary disease (COPD) inflammatory subtypes: an interview with Dr Vanessa McDonald, University of Newcastle, Australia

COPD is defined as a preventable and treatable disease associated with significant extrapulmonary consequences that may contribute to severity. The pulmonary component of COPD is characterised by airflow limitation that is not fully reversible. The airflow limitation is usually progressive with an abnormal inflammatory response of the lungs to noxious particles (GOLD Strategy Document). Airflow obstruction in COPD is not highly variable and largely irreversible.

8 Mar 2013

New NIH collaborative initiative aims to accelerate search for biomarkers in Parkinson's

Last month, the National Institutes of Health announced a new collaborative initiative that aims to accelerate the search for biomarkers -- changes in the body that can be used to predict, diagnose or monitor a disease -- in Parkinson's disease, in part by improving collaboration among researchers and helping patients get involved in clinical studies.

6 Mar 2013

Scientists discover how to detect abnormal brain rhythms associated with Parkinson's

A team of scientists and clinicians at UC San Francisco has discovered how to detect abnormal brain rhythms associated with Parkinson's by implanting electrodes within the brains of people with the disease.

5 Mar 2013

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Sanofi and Regeneron Pharmaceuticals, Inc. announced that pooled data from two Phase 1b trials with dupilumab (REGN668/SAR231893), an investigational, high-affinity, subcutaneously administered, fully-human antibody targeting the alpha subunit of the interleukin 4 receptor (IL-4R alpha), were presented at the 71st Annual Meeting of the American Academy of Dermatology (AAD) in Miami.

4 Mar 2013

Melanoma tumours deliberately create conditions that knock out body's premier immune defence

New research in the Journal of Clinical Investigation reveals that tumours in melanoma patients deliberately create conditions that knock out the body's 'premier' immune defence and instead attract a weaker immune response unable to kill off the tumour's cancerous cells.

2 Mar 2013

Urinary cystatin C prognostic marker in acute kidney injury

Urinary cystatin C level may be a useful biomarker for discriminating between prerenal and intrinsic acute kidney injury, report researchers.

1 Mar 2013

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for under-served medical needs in neurology and cardiology, announced the completion of the interim analysis of the pivotal efficacy study of olesoxime in the rare neurodegenerative condition Spinal Muscular Atrophy (SMA).

1 Mar 2013

Biomarker for testicular sperm extraction outcome discovered

Researchers have used an original proteomic strategy to identify a biomarker for residual spermatogenesis in the semen of patients with nonobstructive azoospermia (NOA).

27 Feb 2013

IntegraGen, Lab21 collaborate to develop new microRNA assay for colorectal cancer

Lab21 Limited, the global specialist in personalised medicine and clinical diagnostics, has entered into an agreement with IntegraGen, a leading player in the development and marketing of molecular diagnostic testing in autism and oncology, to develop a microRNA assay for colorectal cancer designed to further improve patient outcomes.

22 Feb 2013

Researchers determine that neuroblastoma is sensitive to BET bromodomain inhibitors

Neuroblastoma, the most common malignant tumor of early childhood, is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that tumors containing MYCN amplification are sensitive to a new class of drugs, BET bromodomain inhibitors.

22 Feb 2013

Biomarker News and Research

Further Reading

Studies show protein semaphorin 3A helps detect acute kidney injury

New, inexpensive nano-biosensor can detect Listeria monocytogenes in food

RELAX study finds no beneficial effects of erectile dysfunction drug for diastolic heart failure

MiR-198 controls migration of skin cells necessary for wounds to close and heal

New immunoassay appears to be valid screening method for early detection of renal cell carcinoma

Chronic obstructive pulmonary disease (COPD) inflammatory subtypes: an interview with Dr Vanessa McDonald, University of Newcastle, Australia

New NIH collaborative initiative aims to accelerate search for biomarkers in Parkinson's

Scientists discover how to detect abnormal brain rhythms associated with Parkinson's

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Melanoma tumours deliberately create conditions that knock out body's premier immune defence

Urinary cystatin C prognostic marker in acute kidney injury

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

Biomarker for testicular sperm extraction outcome discovered

IntegraGen, Lab21 collaborate to develop new microRNA assay for colorectal cancer

Researchers determine that neuroblastoma is sensitive to BET bromodomain inhibitors

Heart OMics in AGEing project receives European Commission grant

Loyola proposes new subspecialty to diagnose and treat patients with depression, heart disease

Interleukin-10 levels predict otitis media culprit

Government of Québec announces $10M investment in Personalized Medicine Partnership for Cancer

Emory receives NINDS grant for biomarker research on Parkinson's

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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