Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

CWRU researchers discover biomarker for early warning of oral cancer

Detecting oral cancer in its earliest stages can save the lives of the nearly 40,500 people diagnosed annually. But early detection has been difficult.

14 Jul 2010

New research shows Alzheimer's disease may increase risk of other potentially disabling health conditions

Having Alzheimer's disease may increase the risk of getting other potentially disabling health conditions, including seizures and anemia, according to new research presented today at the Alzheimer's Association International Conference on Alzheimer's Disease 2010 in Honolulu, HI.

14 Jul 2010

BioImage Study published in American Heart Journal

BG Medicine, Inc., a U.S.-based biomarker discovery and in vitro diagnostics company, announced today the publication of The BioImage Study trial design and key objectives in the American Heart Journal. The American Heart Journal is a peer- reviewed journal that publishes original research and review articles on clinical research studies in the field of cardiology.

13 Jul 2010

Ophthalmology professor receives $60,000 RPB award to research Sjogren's syndrome

Hui Shao, MD, PhD, associate professor of ophthalmology and visual sciences at the University of Louisville School of Medicine, has received a $60,000 Lew R. Wasserman Merit Award from the Research to Prevent Blindness (RPB) organization. The grant will help fund Shao's research of Sjogren's syndrome, a chronic autoimmune disease that targets the salivary and lacrimal glands - the glands that produce saliva and tears, respectively - resulting in dry mouth and dry eye symptoms.

13 Jul 2010

Roche obtains global co-exclusive license for PI3K biomarker from QIAGEN

Roche announced today that the company has obtained a worldwide co-exclusive license for the biomarker PI3K (phosphoinositide 3-kinase) from QIAGEN to develop real-time and endpoint PCR diagnostic assays. Johns Hopkins University owns the patent for the PI3K biomarker and has previously granted an exclusive license to QIAGEN's wholly owned subsidiary DxS, now QIAGEN Manchester.

From QIAGEN Manchester Limited 13 Jul 2010

New study on impact of bortezomib on mantle cell lymphoma

A new study by researchers from the John Theurer Cancer Center at Hackensack University Medical Center sheds light on how bortezomib (VELCADE-), the first in a new class of cancer drugs known as proteasome inhibitors, works in mantle cell lymphoma. The study also provides preliminary evidence for which patients might benefit most from bortezomib.

13 Jul 2010

New methods may help identify early signs of Alzheimer's disease: Study

Abnormal brain images combined with examination of the composition of the fluid that surrounds the spine may offer the earliest signs identifying healthy older adults at risk of developing Alzheimer's disease, well before cognitive problems emerge, a study by researchers at UC Davis has found.

12 Jul 2010

Alzheimer's Association recognizes four scientists for achievements in Alzheimer research at AAICAD 2010

The Alzheimer's Association recognized four scientists for their extraordinary achievements in advancing Alzheimer research at the Alzheimer's Association International Conference on Alzheimer's Disease 2010 in Honolulu, Hawaii.

12 Jul 2010

Early knowledge of HCC response to TACE determines treatment success: Research article

Early knowledge of hepatocellular carcinoma response to transcatheter arterial chemoembolization is crucial for determining treatment success, timing of repeat treatment, and patient prognosis. Currently, magnetic resonance imaging is used 1-3 mo after treatment to evaluate anatomical tumor response, based upon changes in tumor size and contrast-agent enhancement. Alternatively, diffusion-weighted imaging can be used as a functional imaging technique to depict thermally induced motion of water molecules.

9 Jul 2010

WaferGen Biosystems announces closing of $7.2M registered direct offering

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced the closing of a $7.2 million registered direct offering. The amount raised includes $1 million from the Chairman and CEO, Alnoor Shivji, and approximately $500,000 in the aggregate from four other members of the board of directors of WaferGen.

9 Jul 2010

Biomagnetics, LANL collaborate to develop device for tuberculosis diagnosis

Biomagnetics Diagnostics Corp., a developer of revolutionary technology for diagnostic systems for HIV, hepatitis, tuberculosis and malaria detection, today announced the signing of an agreement with Los Alamos National Security, LLC where Los Alamos National Laboratory's scientific and engineering staffs will attempt to identify new potential human tuberculosis biomarkers and will develop a validated assay to detect human tuberculosis using a currently known biomarker to be used in combination with the waveguide-based optical biosensor platform.

9 Jul 2010

Optics Express publishes special focus issue on lung cancer imaging research

Advanced imaging technologies that promise to improve the development of effective drugs to treat lung cancer are the focus of the current special issue of Optics Express, an open-access journal published by the Optical Society (OSA). Research featured in the special focus issue on Imaging in Diagnosis and Treatment of Lung Cancer outlines standardized approaches to measure and compare tumor size, as well as to validate the accuracy of such measurements under defined settings.

8 Jul 2010

Aethlon Medical files provisional patent on behalf of ESI for exosome detection assay

Aethlon Medical, Inc., the pioneer in developing therapeutic filtration devices to address infectious disease and cancer, announced today that it has filed a provisional patent on behalf of its wholly owned subsidiary Exosome Sciences, Inc. (ESI), relating to the development of an assay that will allow researchers to detect exosomes in blood and other fluids.

8 Jul 2010

MJFF announces $1.1M for projects to develop biomarker candidates for PD

The Michael J. Fox Foundation for Parkinson's Research today announced nearly $1.1 million for projects aimed at advancing the development of leading biomarker candidates for Parkinson's disease. The discovery and validation of biomarkers is of critical importance to increasing the speed and efficiency of PD therapeutic development, allowing scientists and clinicians to more accurately identify appropriate subjects for clinical studies, measure disease progression and monitor treatment effects in clinical trials.

7 Jul 2010

CPRIT grants RBM $3 million Company Commercialization Award to expand OncologyMAP program

Rules-Based Medicine, Inc. (RBM) today announced the Cancer Prevention and Research Institute of Texas (CPRIT) has granted it a Company Commercialization Award to expand and enhance the OncologyMAP™ program for discovery and development of novel diagnostic and prognostic cancer tests. The award of approximately $3 million will fund research and development to more than double the number of cancer-associated biomarker assays in RBM's new OncologyMAP™ product.

6 Jul 2010

Adeona completes $1 million equity financing and provides update on Zinthionein ZC clinical study

Adeona Pharmaceuticals, Inc., announced today that on July 6, 2010, it completed an equity financing of $1 million with a single institutional investor, Seaside 88, L.P. The financing involved the sale of 1,212,121 registered shares of common stock and no warrants. Enclave Capital served as placement agent and will receive a 7% cash commission and 5-year warrants to acquire 60,606 shares of Adeona at $1.32 per share. The use of proceeds is intended for general corporate purposes.

6 Jul 2010

Clusterin associated with development, severity and progression of Alzheimer's disease: Report

Higher concentrations of clusterin, a protein in the blood plasma, appears to be associated with the development, severity and progression of Alzheimer's disease, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

6 Jul 2010

Metabolon unveils novel approach to identify patients at preterm delivery risk

Metabolon, Inc., the leader in global metabolism, biomarker discovery and analysis, announces the publication of "Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery", in The Journal of Maternal-Fetal and Neonatal Medicine.

3 Jul 2010

Neogenix Oncology files patent application with USPTO for 16C3 antigen

Neogenix Oncology announced today that the company has filed a patent application with the U.S. Patent and Trade Office (USPTO) for the 16C3 antigen. The Company believes that this antigen is tumor specific for pancreatic and colorectal tumors; and, based on preliminary clinical data, may also have diagnostic utility as a biomarker for these cancers.

3 Jul 2010

WaferGen Biosystems to raise $7 million in registered direct offering

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced that it has received commitments from certain investors to purchase approximately $7 million of previously unissued securities in a registered direct offering. The investors include the Chairman and CEO, Alnoor Shivji, who has agreed to purchase $1 million of securities in the registered direct offering.

2 Jul 2010

Biomarker News and Research

Further Reading

CWRU researchers discover biomarker for early warning of oral cancer

New research shows Alzheimer's disease may increase risk of other potentially disabling health conditions

BioImage Study published in American Heart Journal

Ophthalmology professor receives $60,000 RPB award to research Sjogren's syndrome

Roche obtains global co-exclusive license for PI3K biomarker from QIAGEN

New study on impact of bortezomib on mantle cell lymphoma

New methods may help identify early signs of Alzheimer's disease: Study

Alzheimer's Association recognizes four scientists for achievements in Alzheimer research at AAICAD 2010

Early knowledge of HCC response to TACE determines treatment success: Research article

WaferGen Biosystems announces closing of $7.2M registered direct offering

Biomagnetics, LANL collaborate to develop device for tuberculosis diagnosis

Optics Express publishes special focus issue on lung cancer imaging research

Aethlon Medical files provisional patent on behalf of ESI for exosome detection assay

MJFF announces $1.1M for projects to develop biomarker candidates for PD

CPRIT grants RBM $3 million Company Commercialization Award to expand OncologyMAP program

Adeona completes $1 million equity financing and provides update on Zinthionein ZC clinical study

Clusterin associated with development, severity and progression of Alzheimer's disease: Report

Metabolon unveils novel approach to identify patients at preterm delivery risk

Neogenix Oncology files patent application with USPTO for 16C3 antigen

WaferGen Biosystems to raise $7 million in registered direct offering

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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