Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Cancer Research Technology and University of Manchester announce collaboration in oncology with AstraZeneca

Cancer Research Technology Limited (CRT), the oncology-focused development and commercialisation company, and The University of Manchester have entered into an agreement with AstraZeneca to establish a clinical pharmacology biomarker research and discovery collaboration.

20 Nov 2006

Cigarette smoking and high HPV concentrations associated with greater risk of cervical cancer

Cigarette smoking and concurrent infection with high levels of the virus associated with cervical cancer can increase cancer risk by as much as 27 times, according to a study published in the November 2006 issue of Cancer Epidemiology, Biomarkers & Prevention.

19 Nov 2006

Gene expression and lung cancer prognosis

While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung cancer patients.

19 Nov 2006

Testosterone replacement therapy appears to be safe - has little effect on the prostate gland

Preliminary research suggests that testosterone replacement therapy for men with low testosterone levels appears to have little effect on the prostate gland, contrary to some reports that this therapy may be harmful, according to a study in the November 15 issue of JAMA: The Journal of the American Medical Association.

14 Nov 2006

Food can have an impact in preventing cancer

With cancer, researchers don't believe "you are what you eat"; that disease is always a direct result of what is, or what isn't, on your dinner plate.

14 Nov 2006

Cancer Research Technology to present discovery updates at BioEurope 2006

Cancer Research Technology Limited (CRT), the oncology-focused development and commercialisation company, today announce that Phil L'Huillier, the Director of Business Management, will present at the BioEurope 2006 Annual International Partnering Conference.

6 Nov 2006

Potential for first diagnostic DNA test to guide antidepressant treatment

Treatment of depression is difficult for both patients and for psychiatrists. While there are numerous drugs available that work, finding the right one -- or right combination -- is, at times, a matter of trial and error.

31 Oct 2006

Nanogen announces new patents for inventions related to diabetes and Alzheimer's disease biomarkers

Nanogen has announced that it has been issued four patents by the U.S. Patent and Trademark Office for inventions related to diabetes and Alzheimer's disease biomarkers.

30 Oct 2006

Biomarkers in blood indicate likelihood of having another stroke

People who have just suffered their first ischemic stroke, a blood clot in the brain, often have elevated inflammatory biomarkers in their blood that indicate their likelihood of having another stroke or an increased risk of dying, according to Columbia University Medical Center researchers at NewYork-Presbyterian Hospital.

24 Oct 2006

New study emphasizes the importance of metabolomics to the advent of personalized medicine

International experts have collaborated on a comprehensive collection of reviews focusing on the emerging interface between metabolomics and pharmacogenomics.

24 Oct 2006

$74 million allocated to study environmental causes of disease

As part of the new Exposure Biology Program, the National Institute of Environmental Health Sciences, a component of the National Institutes of Health, today announced $74 million in grant opportunities for the development of new technologies that will improve the measurement of environmental exposures that contribute to human disease.

19 Oct 2006

Heme oxygenase-1 protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

16 Oct 2006

Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers

In an attempt to increase the sensitivity of cancer biomarker detection and to decrease the need for large samples from which to detect those molecules, a multi-institutional research team has shown that a "forest" of single-walled carbon nanotubes can be used to detect lower levels of the prostate specific antigen (PSA) than is possible using the current commercial assay.

25 Sep 2006

Detecting cancer with silica nanoparticles

Tumor necrosis factor-alpha is a widely accepted biomarker for cancer, but the minute amounts of this protein circulating in blood makes detecting the molecule and measuring its concentration accurately a technological challenge.

19 Sep 2006

NIH to map genomic changes of lung, brain, and ovarian cancers

It is estimated that 174,470 new cases of lung cancer will be diagnosed in the United States in 2006. Lung cancer is the major cause of cancer-related mortality in both men and women, with an estimated 162,460 deaths expected to occur in 2006.

13 Sep 2006

High levels of two proteins in the bloodstream indicate need for action to avoid heart attack

Researchers working to decode chemical SOS signals sent out by disease-damaged hearts believe they now know better when to aggressively clear clogged arteries and when medical procedures may be unnecessary and even harmful.

12 Sep 2006

Link between weight loss and dementia

A long-term study of the elderly has revealed that their average rate of weight loss doubles in the year before symptoms of Alzheimer's-type dementia first become detectable.

12 Sep 2006

GRK2 protein -a potential biomarket for heart failure

A team of cardiology researchers at Thomas Jefferson University has determined that GRK2, a protein that plays an important regulatory role in heart failure, is elevated in patients with failing hearts when compared to patients with normal heart function.

12 Sep 2006

Vitamin D cuts the risk of pancreatic cancer

Consumption of Vitamin D tablets was found to cut the risk of pancreatic cancer nearly in half, according to a study led by researchers at Northwestern and Harvard universities.

12 Sep 2006

UIC receives $20 million NCI grant to research blood disorders

A $19.6 million National Cancer Institute grant has been awarded to the University of Illinois at Chicago College of Medicine to advance basic and clinical research for incurable blood disorders.

6 Sep 2006

Biomarker News and Research

Further Reading

Cancer Research Technology and University of Manchester announce collaboration in oncology with AstraZeneca

Cigarette smoking and high HPV concentrations associated with greater risk of cervical cancer

Gene expression and lung cancer prognosis

Testosterone replacement therapy appears to be safe - has little effect on the prostate gland

Food can have an impact in preventing cancer

Cancer Research Technology to present discovery updates at BioEurope 2006

Potential for first diagnostic DNA test to guide antidepressant treatment

Nanogen announces new patents for inventions related to diabetes and Alzheimer's disease biomarkers

Biomarkers in blood indicate likelihood of having another stroke

New study emphasizes the importance of metabolomics to the advent of personalized medicine

$74 million allocated to study environmental causes of disease

Heme oxygenase-1 protects against lung damage in silicosis

Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers

Detecting cancer with silica nanoparticles

NIH to map genomic changes of lung, brain, and ovarian cancers

High levels of two proteins in the bloodstream indicate need for action to avoid heart attack

Link between weight loss and dementia

GRK2 protein -a potential biomarket for heart failure

Vitamin D cuts the risk of pancreatic cancer

UIC receives $20 million NCI grant to research blood disorders

Breaking Barriers: ANDYSMANCLUB's Fight for Men's Mental Health on World Mental Health Day

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

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