Bone News and Research

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Stem cell therapy leads to development of blood vessel, bone marrow masses

Following stem cell therapy, an adult patient experienced a new and previously unrecognized complication, which required removal of one of the kidneys, according to a case report appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The report suggests that stem cell therapy may cause patients to develop blood vessel and bone marrow masses, the long term effects of which are unknown.

18 Jun 2010

One-step surgery positively impacts patient's quality of life: Study

Restoring people's health and returning them to their daily lives as soon as possible is the goal following any surgery. When a person's ability to eat and speak is affected, as with cancer in the mouth, surgery is particularly disruptive, creating a greater challenge. A one-step surgery can remove cancerous tissue and reconstruct bone and teeth functionality immediately, positively impacting the patient's quality of life.

18 Jun 2010

Bone samples act as the ultimate biomarker for environmental pollution: Researchers

Exposure to chemical pollutants is of growing concern to regulators, health workers, and environmentalist groups alike. Now, researchers in the US and Russia have demonstrated that samples of human bone can act as a biological marker for dozens of metals and toxic elements across the periodic table. They describe details in a study published in the International Journal of Environment and Health.

18 Jun 2010

Review of possible uses, limits of WB-MRI procedure

Thanks to technical progress, there are now new areas in which whole body magnetic resonance imaging can be used. In the current edition of Deutsches -rzteblatt International (Dtsch Arztebl Int 2010; 107[22]: 383-9), Gerwin Schmidt and his coauthors present a review of possible uses, together with the limits of this radiation-free diagnostic procedure.

18 Jun 2010

ASH announces recipients of 2010 ASH Research Training Award for Fellows

The American Society of Hematology is pleased to announce the five recipients of the 2010 ASH Research Training Award for Fellows, a grant that encourages junior researchers to pursue careers in academic hematology by supporting protected time to conduct research during their fellowship training.

18 Jun 2010

Postmenopausal women who have low calcium intake show higher risk of developing osteoporosis, hypertension

Italian postmenopausal women who have a low calcium intake show a higher risk of developing both osteoporosis and hypertension (a chronic medical condition in which arterial blood pressure is elevated) than those who consume higher levels of calcium according to research presented today at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy.

18 Jun 2010

First patient dosed in AR-42 Phase I/IIa clinical study at OSUCCC-James in adult patients with blood cancer

Arno Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing oncology therapeutics, today announced the dosing of the first patient in an investigator sponsored Phase I/IIa clinical study of AR-42 (formerly OSU-HDAC42) at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) in adult patients with relapsed or refractory multiple myeloma (MM), chronic lymphocytic leukemia (CLL) or lymphoma.

18 Jun 2010

FDA approves new indication for Tasigna in treatment of rare blood cancer

The U.S. Food and Drug Administration today approved a new indication for Tasigna (nilotinib) for the treatment of a rare blood cancer when it is first diagnosed. The cancer, called Philadelphia chromosome positive chronic phase chronic myeloid leukemia (Ph+ CP-CML), is a slowly progressing blood and bone marrow disease linked to a genetic abnormality.

18 Jun 2010

First implantation of PyroTITAN Humeral Resurfacing Arthroplasty performed outside US in Australia

Ascension Orthopedics, Inc., a market leader in PyroCarbon orthopedic implants, announces the first implantation of the PyroTITAN™ Humeral Resurfacing Arthroplasty outside the United States. The PyroTITAN was implanted last month in Brisbane, Australia in a 46-year-old patient who reported "immediate pain relief" within 24 hours of surgery. The PyroTITAN Humeral Resurfacing implant is the first commercially-available shoulder arthroplasty prosthesis made of PyroCarbon in the world.

17 Jun 2010

VBL presents positive preclinical data on VB-201 for rheumatoid arthritis at EULAR

VBL Therapeutics, a clinical-stage biotechnology company committed to the development of novel treatments for immune-inflammatory diseases and cancer, today announced preclinical data demonstrating that VB-201 possesses anti-inflammatory properties and effectively reduced the symptoms of arthritis in experimental models.

17 Jun 2010

Researchers assess effect of MDs on cardiac and endothelial cell proliferation, survival

A research team from McGill University (Canada) report a beneficial effect on cardiac function in mouse models when implanted monocytes - a type of white blood cell that is part of the immune system - helped preserve cardiac function following a heart attack (myocardial infarction).

17 Jun 2010

CINJ researchers combine series of vaccination injections to treat prostate cancer

Looking to harness the body's own immune system to target prostate cancer that has spread to the bones (metastatic) and is unresponsive to standard treatment, investigators at The Cancer Institute of New Jersey have just launched a clinical trial focusing on a combination of vaccine and radiation drug therapy.

17 Jun 2010

Bacterin International to distribute biologic products to Broadlane network of medical institutions

Bacterin International, Inc., a developer of revolutionary bone graft material, today announced a three-year agreement to provide its biologic line of products, OsteoSponge®, OsteoSelect®, OsteoSponge SC®, OsteoWrap®, BacFast®, and OsteoLock®, to the vast Broadlane® nationwide network of hospitals and medical practices.

17 Jun 2010

Research findings could lead to less invasive treatments for ALL

A team of researchers from the Institute for Research in Immunology and Cancer of the Universit- de Montr-al have defined for the first time the mechanism behind three cancer-causing genes in acute lymphoblastic leukemia. Published in the journal Genes and Development, the findings offer insight on the complex interaction between the genes and their contributions to leukemia, thereby providing the foundation for the design of targeted therapies.

17 Jun 2010

FDA approves clinical testing of SanBio's SB623 for stroke recovery

SanBio Inc. announced today that the United States Food and Drug Administration (FDA) has approved the clinical testing of their SB623 regenerative medicine product in patients suffering from disability caused by cerebral stroke. SB623 is derived from bone marrow stromal cells (MSCs) isolated from healthy adult donors.

17 Jun 2010

Injectable bone carries living stem cells

A team of researchers at the University of Nottingham have invented a new class of materials that can be injected by surgeons as a low-viscosity fluid into the body that, using body heat as the only trigger, converts into a tough porous material with mechanical properties that mimic human cancellous bone.

16 Jun 2010

Abbott, Neurocrine enter collaboration to develop, commercialize elagolix for endometriosis-related pain

Abbott and Neurocrine Biosciences, Inc. today announced that they have entered into a collaboration agreement to develop and commercialize elagolix for the treatment of endometriosis-related pain. Elagolix is a novel, first-in-class oral gonadotropin-releasing hormone (GnRH) antagonist, which has recently completed a phase IIb study in endometriosis. In addition to endometriosis, elagolix will be evaluated for the treatment of uterine fibroids.

16 Jun 2010

Degradable implant stimulates body to regenerate

In a medical emergency, a puncture of the cranium is commonly treated with an implant. While replacements made of titanium merely plug holes, a new kind of degradable implant stimulates the body to regenerate itself: It is custom-fit and disappears to the same extent that the bone regrows.

16 Jun 2010

joimax moves into larger premises in Germany, US

The medical devices company joimax(R) GmbH is moving into new premises both in Germany and the US. "Growth requires space" had already been the motto of the last company move back in 2005.

16 Jun 2010

Newly published research examines association between CKD and CYP24

Cytochroma today announced the publication of new data from studies in a preclinical model indicating that chronic kidney disease is associated with markedly increased expression of the vitamin D catabolic enzyme, CYP24, which contributes to vitamin D insufficiency and resistance to vitamin D therapy. Parallel analysis of kidney biopsies obtained from CKD patients confirmed abnormal CYP24 expression in human disease as well.

16 Jun 2010

Bone News and Research

Stem cell therapy leads to development of blood vessel, bone marrow masses

One-step surgery positively impacts patient's quality of life: Study

Bone samples act as the ultimate biomarker for environmental pollution: Researchers

Review of possible uses, limits of WB-MRI procedure

ASH announces recipients of 2010 ASH Research Training Award for Fellows

Postmenopausal women who have low calcium intake show higher risk of developing osteoporosis, hypertension

First patient dosed in AR-42 Phase I/IIa clinical study at OSUCCC-James in adult patients with blood cancer

FDA approves new indication for Tasigna in treatment of rare blood cancer

First implantation of PyroTITAN Humeral Resurfacing Arthroplasty performed outside US in Australia

VBL presents positive preclinical data on VB-201 for rheumatoid arthritis at EULAR

Researchers assess effect of MDs on cardiac and endothelial cell proliferation, survival

CINJ researchers combine series of vaccination injections to treat prostate cancer

Bacterin International to distribute biologic products to Broadlane network of medical institutions

Research findings could lead to less invasive treatments for ALL

FDA approves clinical testing of SanBio's SB623 for stroke recovery

Injectable bone carries living stem cells

Abbott, Neurocrine enter collaboration to develop, commercialize elagolix for endometriosis-related pain

Degradable implant stimulates body to regenerate

joimax moves into larger premises in Germany, US

Newly published research examines association between CKD and CYP24

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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