Bone News and Research

RSS

U of M sets new standard of care for recessive dystrophic epidermolysis bullosa

Physicians at the University of Minnesota and University of Minnesota Children's Hospital, Fairview have set the path to a cure for a young boy's fatal genetic skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant. Nate Liao, a 25-month-old from Clarksburg, N.J., underwent the experimental therapy in October 2007.

3 Jun 2008

Nanotechnology specialist discovers method to regenerate cartilage naturally

Scientists have long wrestled with how to aid those who suffer cartilage damage and loss. One popular way is to inject an artificial gel that can imitate cartilage's natural ability to act as the body's shock absorber. But that solution is temporary, requiring follow-up injections.

3 Jun 2008

Arana and Greenovation in anti-cancer co-development deal

Arana Therapeutics Limited and Germany-based greenovation Biotech GmbH have entered into a collaborative agreement to develop next generation anti-cancer antibodies.

2 Jun 2008

Low levels of vitamin D appear common in healthy children

Many healthy infants and toddlers may have low levels of vitamin D, and about one-third of those appear to have some evidence of reduced bone mineral content on X-rays, according to a report in the June issue of Archives of Pediatrics & Adolescent Medicine.

2 Jun 2008

Meniscal damage and joint malalignment predictors of cartilage loss

Marked by cartilage and bone degradation, progressive knee osteoarthritis (OA) is believed to result in part from a combination of several local mechanical factors. Lack of joint stability, poor joint alignment and injuries to the disks of meniscal tissue that cushion the knee all affect load distribution and the toll to the vulnerable OA knee.

2 Jun 2008

New approach to treating autoimmune disease offered by Weizmann scientists

In autoimmune diseases, the immune system turns against the body's own tissues and organs, wreaking havoc and destruction for no apparent reason. Partly because the origins of these diseases are so obscure, no effective treatment exists, and the suffering they inflict is enormous.

2 Jun 2008

Oncolytics Biotech announces results for intravenous Reolysin in patients with sarcomas metastatic to the lung

Oncolytics Biotech Inc. has announced that interim results of a Phase II study of intravenous Reolysin in patients with sarcomas metastatic to the lung were presented yesterday at the American Society of Clinical Oncology (ASCO) annual meeting.

2 Jun 2008

Genta announces initial trial results for novel drug for bone disease

Genta Incorporated has announced the release of final results from the Company's Phase 1 clinical trial of G4544, a proprietary small molecule that is intended as a treatment for diseases associated with accelerated bone loss. Results showed that the drug was very well-tolerated, and that blood levels were achieved in a range that is known to be clinically bioactive. The data were featured in a poster session at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago on Saturday, May 31, 2008.

2 Jun 2008

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy. That is, the suppression of circulating testosterone - the hormone that fuels prostate-cancer growth - via surgical castration (orchiectomy) or medical castration with testosterone-blocking drugs. While such therapy buys time for patients, it is not a cure, as inevitably the cancer becomes resistant to the androgen deprivation and continues to grow.

2 Jun 2008

First study to examine vitamin D insufficiency in pediatric patients with low bone density

Vitamin D insufficiency is common in adults and is emerging in the world of pediatrics. A mild degree of vitamin D deficiency, also known as vitamin D insufficiency, causes rickets in children and can be treated with increased amount of nutritional vitamin D intake as well as increased sun exposure.

2 Jun 2008

Potential hypophosphatasia therapy discovered

Researchers at the Burnham Institute for Medical Research, led by José Luis Millán, Ph.D., have demonstrated in mice the first successful use of enzyme replacement therapy to prevent hypophosphatasia (HPP), a primary skeletal disease of genetic origin. This discovery lays the foundation for future clinical trials for HPP patients.

1 Jun 2008

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

1 Jun 2008

Sen. Kennedy to introduce bill to revise national cancer act

Sen. Edward Kennedy (D-Mass.), who recently was diagnosed with brain cancer, previously had begun work on legislation that would revise the 1971 National Cancer Act, and supporters hope that the "fact that Kennedy has fallen victim to this disease will generate public support and lend new urgency to the need to update the bill," the AP/Chicago Tribune reports.

30 May 2008

Lack of dental care may have life-threatening implications

New research from the University of Bristol shows that admissions for the surgical treatment of dental abscess have doubled in the last ten years despite the fact that these serious infections are preventable with regular dental care.

29 May 2008

Post-menopausal therapy to improve women's quality of life

A recent research work by the University of Granada advises post-menopausal women the use of Replacement Hormone Therapy (RHT) for at least five years.

29 May 2008

Avoiding spleen removal for Cooley's anemia sufferers

Researchers from Weill Cornell Medical College may have discovered the precise role of a gene in one of the world's most common blood disorders, beta-thalassemia, commonly known as Cooley's anemia. Along with sickle-cell anemia, Cooley's anemia is the most commonly inherited disease in the world, affecting many people of Mediterranean descent, and 20 out of every 100,000 African-Americans. The World Health Organization estimates that between 50,000-100,000 children are born with the disease each year.

27 May 2008

Gum disease an indicator of increased cancer risk

British scientists say gum disease, both in smokers and non-smokers, may be a warning sign of an increased risk of cancer.

27 May 2008

Bone repair using patient's stem cells comes closer

Hitherto it has been difficult to induce adult human stem cells to produce bone, e.g. in order to repair bone tissue. Researchers at the University of Twente have shown that if the enzyme PKA is previously activated in the stem cells in the lab, following implantation this results in substantial bone formation.

26 May 2008

Children should drink milk to help prevent osteoporosis

For generations children have been urged to drink milk for strong. healthy bones and teeth. New research from Southampton, UK, announced today (26 May) is taking this a step further, showing the link between drinking mild and reducing the risk of osteoporosis in later life.

26 May 2008

HIV patients suffer more from osteoporosis

Following the introduction of HAART (Highly Active Antiretroviral Therapy), the survival and quality of life for people infected with the human immunodeficiency virus (HIV-1) have increased in the resource-rich countries. However, with this improved prognosis an increase in long term negative disorders has been observed, namely osteoporosis (the gradual loss of bone mass).

25 May 2008