Bone News and Research

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Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.

16 Apr 2006

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

An international research team has identified what may be a critical molecule in the ability of tumours to metastasize -- or spread -- into bone.

13 Apr 2006

Statins may be able to play a role in preventing or slowing heart valve disease

Research to be published in the April 18 issue of the Journal of the American College of Cardiology provides the first explanation of an active rather than passive process that leads to heart valve degeneration, furthering a Northwestern researcher's effort to lead a paradigm shift in the medical community's beliefs about the cause of valve disease.

11 Apr 2006

New insights into how anti-rejection drug daclizumab (Zenapax) helps MS patients

A research team led by the University of Cincinnati's Bibiana Bielekova, MD, report new insights into the role of the MS drug daclizumab (Zenapax) in the Proceedings of the National Academy of Sciences.

11 Apr 2006

Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy

The patient of a periodontist in private practice in New Orleans developed osteonecrosis of the jaw (ONJ), a condition that can cause severe, often irreversible and debilitating damage to the jaw, following periodontal surgical therapy.

11 Apr 2006

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

A study led by researchers from the Howard Hughes Medical Institute has found that dasatinib provides significant benefit in chronic myeloid leukemia (CML) patients resistant to Gleevec. (imatinib), according to a study presented during the 97th Annual Meeting of the American Association for Cancer Research.

11 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

Losartan can prevent progression of Marfan syndrome

A commonly prescribed blood pressure medication may provide the first ray of hope in preventing potentially deadly complications of Marfan syndrome, a genetic disease that weakens the structural meshwork of blood vessels.

11 Apr 2006

Salivary biomarkers of existing periodontal disease

A University of Kentucky study published in the Journal of American Dental Association could help change the diagnosis and treatment of periodontal disease.

11 Apr 2006

MPD Foundation funds research for incurable blood disorders

The Myeloproliferative Disorders Foundation has awarded $750,000 to establish the MPD Research Alliance, a collaboration of the University of Illinois at Chicago, Harvard Medical School and Mayo Clinic to accelerate drug development for incurable, progressive bone marrow disorders.

11 Apr 2006

Early intervention is a critical consideration in efforts to preserve the musculoskeletal system after spinal cord injury

Richard Shields, Ph.D., University of Iowa professor in the Graduate Program in Physical Therapy and Rehabilitation Science, can foresee a time when it might be possible to cure spinal cord injury (SCI).

7 Apr 2006

Study of predictors of vitamin D status and cancer incidence and mortality in men

Low levels of vitamin D may be associated with increased total cancer incidence and mortality in men, particularly for cancers of the digestive system, according to a study in the Journal of the National Cancer Institute.

7 Apr 2006

Folic acid may be added to all bread in Britain

The Food Standards Agency in the UK is recommending the addition of the vitamin folic acid to all flour and bread on sale in Britain within the next year.

5 Apr 2006

Menopause linked with the onset of depression

Two new studies say women with no history of depression may be at an increased risk of depressive symptoms and disorders as they enter menopause.

5 Apr 2006

Adult stem cells can be used to make new tendon or ligament tissue

Weekend athletes who overexert themselves running or playing basketball may one day reap the benefits of research at the Hebrew University of Jerusalem that shows that adult stem cells can be used to make new tendon or ligament tissue.

4 Apr 2006

Multi-site vaccinations could protect against all four dengue viruses

An innovative new study explains, for the first time, the failure of previous attempts to vaccinate against the four known Dengue viruses, and it suggests a very simple solution - injecting the four vaccines simultaneously at different locations on the body.

4 Apr 2006

Link between lead and osteoporosis strengthens

Bolstered by recent laboratory findings, researchers at the University of Rochester Medical Center are embarking on a National Institutes of Health-funded clinical study to better understand the deceptive role environmental lead exposure plays in bone maturation and loss.

4 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Inflammation, cartilage and bone erosions, joint destruction--that's the typical progression of arthritis and most rheumatic diseases.

4 Apr 2006

St. Jude develop relatively simple and inexpensive test for acute lymphoblastic leukemia

Investigators at St. Jude Children's Research Hospital have developed a relatively simple and inexpensive test that identifies children with acute lymphoblastic leukemia (ALL) who have responded well enough to their first round of chemotherapy that they might be successfully treated with a much less aggressive follow-up treatment.

3 Apr 2006

Bone News and Research

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

Statins may be able to play a role in preventing or slowing heart valve disease

New insights into how anti-rejection drug daclizumab (Zenapax) helps MS patients

Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy

Dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

Losartan can prevent progression of Marfan syndrome

Salivary biomarkers of existing periodontal disease

MPD Foundation funds research for incurable blood disorders

Early intervention is a critical consideration in efforts to preserve the musculoskeletal system after spinal cord injury

Study of predictors of vitamin D status and cancer incidence and mortality in men

Folic acid may be added to all bread in Britain

Menopause linked with the onset of depression

Adult stem cells can be used to make new tendon or ligament tissue

Multi-site vaccinations could protect against all four dengue viruses

Link between lead and osteoporosis strengthens

Targeting the inflamed synovium: The quest for specificity

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

St. Jude develop relatively simple and inexpensive test for acute lymphoblastic leukemia

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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