Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Treatment with luspatercept improves red blood cell counts in patients with myelodysplastic syndromes

Treatment with luspatercept improved red blood cell counts and erythroid responses compared to treatment with epoetin alfa in patients with myelodysplastic syndromes (MDS), allowing the majority to no longer require regular blood transfusions.

26 May 2023

Nonhuman primate study helps explain how stem cell transplantation can kill HIV virus

New animal research is helping explain why at least five people have become HIV-free after receiving a stem cell transplant.

25 May 2023

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine.

25 May 2023

Looking at cancer drugs to help put the brakes on classic indicators of aging

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Researchers report the role of RNA-binding protein Msi 1 to maintain breast cancer stem cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, "Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow."

16 May 2023

Cancer patients can initiate SARS-CoV-2 vaccination three months after bone marrow transplant

Patients with cancer whose immune systems are being supported or rebuilt by bone marrow transplantation should begin receiving vaccines for protection against SARS-CoV-2 three months post-transplant, according to a large, prospective, observational study led collaboratively by the Center for International Blood and Marrow Transplant Research, the Blood & Marrow Transplant Clinical Trials Network and Fred Hutchinson Cancer Center.

16 May 2023

Obesity strongly associated with clonal hematopoiesis of indeterminate potential

Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that obesity was strongly associated with the condition.

16 May 2023

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumor that most commonly arises in the adrenal gland.

15 May 2023

Targeting the hemoglobin problem in sickle cell disease using a new drug

A class of drugs used for their ability to stop tumor cells from dividing is now under study for their potential to reduce the pain and damage caused by sickle cell disease, investigators report.

11 May 2023

Addition of palliative care services to cancer patients having surgery does not provide benefits

One of the most important advances in palliative care in oncology over the past 15 years has been the recognition that palliative care specialists can improve cancer patients' outcomes well before their end of life.

10 May 2023

Breast cancer tumors disrupt the development of an immune response to favor their own growth

Researchers at Baylor College of Medicine and collaborating institutions have identified a strategy cancerous tumors use to remotely disrupt the development of an immune response that could stop their growth.

5 May 2023

New approach addresses the challenge of directly connecting genetic variants to human traits, health

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

Testing hundreds of existing therapeutics to fight blood cancer more effectively

Multiple myeloma is a rare blood cancer caused by the uncontrolled multiplication of abnormal plasma cells.

27 Apr 2023

Does oral exposure to cannabidiol (CBD) have toxic implications?

Researchers reviewed the implications of oral exposure to cannabidiol (CBD).

25 Apr 2023

New computational method identifies routes of cellular differentiation in acute myeloid leukemia

Researchers have developed a new method to distinguish between cancerous and healthy stem cells and progenitor cells from samples of patients with acute myeloid leukemia (AML), a disease driven by malignant blood stem cells that have historically been difficult to identify.

24 Apr 2023

Bone Marrow News and Research

Further Reading

Treatment with luspatercept improves red blood cell counts in patients with myelodysplastic syndromes

Nonhuman primate study helps explain how stem cell transplantation can kill HIV virus

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Looking at cancer drugs to help put the brakes on classic indicators of aging

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Mast cells play a crucial role in the development of chronic myeloid leukemia

Researchers report the role of RNA-binding protein Msi 1 to maintain breast cancer stem cells

Cancer patients can initiate SARS-CoV-2 vaccination three months after bone marrow transplant

Obesity strongly associated with clonal hematopoiesis of indeterminate potential

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Targeting the hemoglobin problem in sickle cell disease using a new drug

Addition of palliative care services to cancer patients having surgery does not provide benefits

Breast cancer tumors disrupt the development of an immune response to favor their own growth

New approach addresses the challenge of directly connecting genetic variants to human traits, health

Testing hundreds of existing therapeutics to fight blood cancer more effectively

Does oral exposure to cannabidiol (CBD) have toxic implications?

New computational method identifies routes of cellular differentiation in acute myeloid leukemia

Research findings could help inform more effective therapies for AML

Mitophagy helps blood cancer cells to evade the killing effects of BH3 mimetic drug

Researchers develop a backpack-based myeloid cell therapy for MS patients

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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