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Old drug pentylenetetrazole may improve learning and memory in Down syndrome victims

Researchers in the United States have discovered that an old drug once used to study epilepsy substantially improved learning and memory in mice with Down syndrome symptoms.

26 Feb 2007

Alternative, diet-based method of treating brain cancer

The biologists found that KetoCal, a commercially available high-fat, low-carbohydrate diet designed to treat epilepsy in children, can significantly decrease the growth of brain tumors in laboratory mice.

22 Feb 2007

UK scientists reverse symptoms of mad cow disease

The researchers at University College, London, believe they have found a way to treat the disease in humans as long as it is detected before it has done harm to a large number of brain cells.

1 Feb 2007

Effects of prion disease could be reversed if caught early enough

The researchers said that their findings support developing early treatments that aim to reduce levels of prion protein in the brains of people with prion disease.

31 Jan 2007

Calpain-mediated mGluR1-alpha truncation

Tricking a key enzyme can soothe over-excited receptors in the brain, say neuroscientists, calling this a possible strategy against stroke, Alzheimer's and other neurodegenerative diseases.

31 Jan 2007

FDA approves Neuren's phase 3 Glypromate trial

Neuren Pharmaceuticals has announced that the US Food and Drug Administration (FDA) has accepted its investigational new drug application (IND) and authorised the Company to proceed with its Phase 3 trial to prevent cognitive impairment following major cardiac surgery using Glypromate.

30 Jan 2007

Scientists tackle huntingtin protein

McMaster scientists are very close to defining small molecule drugs that should be able to redirect the huntingtin protein from accumulating in the wrong place within brain cells, which could potentially translate to a therapy for Huntington's Disease (HD).

29 Jan 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

Manipulation of proliferation and differentiation of human bone marrow derived neural stem cells in vitro and in vivo

Stem cells taken from adult human bone marrow have been manipulated by scientists at the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center to generate aggregates of cells called spheres that are similar to those derived from neural stem cells of the brain.

28 Jan 2007

Canadian researchers discover distinct dopamine signalling complex in the brain

Composed of two different types of dopamine receptors, this novel target may have a significant role in understanding and treating schizophrenia.

23 Jan 2007

Stem cells derived from human amniotic fluid appear to offer many of the benefits of embryonic stem cells

...including the ability to grow into brain, muscle, bone and other tissues -- according to a study published in the Jan. 7 online edition on the journal Nature Biotechnology, the Washington Post reports.

9 Jan 2007

New hope for Krabbe disease sufferers

By all expectations, it shouldn't have worked as well as it did. A combination of bone marrow transplantation and gene therapy greatly lengthened the lives of laboratory mice doomed by a rapidly progressing, fatal neurodegenerative disorder also found in people.

9 Jan 2007

TrkB and its role in learning and memory

For the first time researchers investigate the molecular basis of memory in living mice.

9 Jan 2007

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Glioblastoma multiforme is among the most aggressive and difficult cancers to treat. Now, researchers at Penn State University have shown that a lipid-based nanoparticle, designed to bind to a specific receptor found on malignant brain cells but not healthy ones, improves the potency of a common anticancer drug and slows significantly the growth of glioblastoma in mice.

8 Jan 2007

Herpes appears to play a role in bringing about Alzheimer's disease

A gene known to be a major risk factor for Alzheimer's disease puts out the welcome mat for the virus that causes cold sores, allowing the virus to be more active in the brain compared to other forms of the gene.

3 Jan 2007

A central thermogenic-like mechanism in feeding regulation

During periods of fasting, brain cells responsible for stimulating the appetite make sure that you stay hungry.

2 Jan 2007

Stem cells grown into brain cells on a new 3D scaffold of tiny protein fragments

An MIT engineer and Italian colleagues will report the invention-which may one day replace the ubiquitous Petri dish for growing cells-in PLoS ONE.

2 Jan 2007

Chemo drugs damage healthy brain cells

According to new research chemotherapy drugs which are used to treat cancer, damage the brain.

4 Dec 2006

Human embryonic stem cells show potential in treating rats with Parkinson's symptoms

Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson's-like symptoms dramatically, but the treatment caused a significant problem - the appearance of brain tumors - that scientists are now working to solve.

2 Dec 2006

Guanfacine no more effective than a placebo

Guanfacine, a medication commonly prescribed to alleviate symptoms of post-traumatic stress disorder, is no more effective than a placebo, according to a study led by researchers at the San Francisco VA Medical Center.

2 Dec 2006