Brain Disease News and Research

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New insights into astrocytes offer hope for Alzheimer's treatment

A research team led by Dr. Hoon Ryu from the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh) Brain Disease Research Group, in collaboration with Director Justin C. Lee of the Institute for Basic Science (IBS, President Do-Young Noh) and Professor Junghee Lee from Boston University Chobanian & Avedisian School of Medicine, has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target.

30 Sep 2024

Neurostimulation target identified for treating PTSD in veterans

A new study led by researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that using neurostimulation therapies on a specific brain network could treat post traumatic stress disorder (PTSD) in veterans.

24 Sep 2024

Study helps explain why having ApoE4 increases risk of neurodegeneration

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.

18 Sep 2024

Study reveals shared and unique molecular markers across multiple forms of dementia

Researchers have for the first time identified degeneration-associated "molecular markers" – observable changes in cells and their gene-regulating networks – that are shared by several forms of dementia that affect different regions of the brain.

11 Sep 2024

Violent dementia patients leave nursing home staffers and residents ‘scared to death’

Dan Shively had been a bank president who built floats for July Fourth parades in Cody, Wyoming, and adored fly-fishing with his sons.

9 Aug 2024

The real cost of processed foods: How Western diets are harming global health

A recent study in Nature Medicine reviews the adverse effects of Western diets on human health, highlighting increased risks of chronic diseases and gut dysbiosis. Researchers call for global awareness and promotion of healthier dietary patterns.

6 Aug 2024

Higher Brain Care Score associated with lower risk of late-life depression

Late-life depression, typically defined as depression with onset in individuals over 60 years of age, can affect up to a third or more of people older than 60 and can be debilitating.

23 Jul 2024

Experts identify sex and gender differences in cognitive resistance and resilience to Alzheimer's disease

Researchers investigated sex-related and gender-specific resistance and resilience factors in Alzheimer's disease.

10 Jul 2024

Challenging the chronic brain disease model of addiction

Addiction is not simply a chronic brain disease and considering it as such can limit treatment options and increase stigma, an extensive research review suggests.

1 Jul 2024

CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Novel therapeutic approach shows promise for frontotemporal dementia in pre-clinical trials

Pre-clinical trials: A new therapeutic approach for the severe condition uses modified viruses to replace a missing protein in the brain.

7 Jun 2024

Two new studies offer insights into the molecular biology of neuropsychiatric disease

Working under the umbrella of the PsychENCODE Consortium, the mental health research project established in 2015 by the National Institutes of Health, a team of Mount Sinai scientists has uncovered important new insights into the molecular biology of neuropsychiatric disease through two new studies published in a special issue of Science on Friday, May 24.

24 May 2024

Comprehensive study provides new understandings of genomic influences on neuropsychiatric disease

A new analysis has revealed detailed information about genetic variation in brain cells that could open new avenues for the targeted treatment of diseases such as schizophrenia and Alzheimer's disease.

23 May 2024

Australian scientists explore how harmful bacteria contribute to Alzheimer's

The phrase 'you are what you eat' was coined almost a century before Alois Alzheimer made his breakthrough in identifying brain disease, but the evidence is now clear that diet as well as age influences the brain.

22 May 2024

Novel gene-delivery vehicle shows promise for treating brain disorders

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

16 May 2024

Unraveling the mystery of Alzheimer's resilience at molecular level

Everyone experiences aging in their own way, and factors such as genetics, lifestyle and environment play a role in this process.

16 May 2024

Genes affecting worm behavior found to be relevant to neurological disease in humans

As an undergraduate student in The University of Texas at Arlington's Honors College, Hannah Selvarathinam knew she wanted to conduct research. Near the end of her first year at UTA, the Keller native reached out to the lab of biology Assistant Professor Piya Ghose.

30 Apr 2024

Parkinson’s UK invests £2.1 million in Neumora Therapeutics for preclinical testing of new Parkinson’s drug

Parkinson’s UK is investing £2.1million to support Neumora Therapeutics to carry out preclinical testing of NMRA-NLRP3, a NLRP3 inhibitor with the potential to reduce inflammation and protect brain cells in Parkinson’s. NLRP3 is a protein that plays a role in regulating a number of inflammatory processes that are believed to contribute to the damage to brain cells that underlies Parkinson’s.

27 Apr 2024

Study reveals high prevalence of menstrual migraines in U.S. women

A third of the nearly 20 million women who participated in a national health survey report migraines during menstruation, and of them, 11.8 million, or 52.5%, were premenopausal.

13 Apr 2024

Gene discovery provides new insight into brain calcification

Brain calcification can cause movement disorders and cognitive impairment. Researchers at the Arnesen Lab at UiB have now identified a gene that provides new insight into how these calcifications occur.

14 Mar 2024