Brain Metastases News and Research

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CNIO’s collaborative platform simplifies research on brain metastasis

Science is collaborative by nature, since scientific knowledge only advances, step by step, through combined efforts and findings. Nevertheless, there is often a lack of communication regarding the more technical and everyday advances in laboratory work, and as a result research progresses less quickly.

8 Jul 2020

Study reveals outcomes of radiosurgery for patients with brain metastases from small cell lung cancer

The international First-line Radiosurgery for Small-Cell Lung Cancer analysis led by University of Colorado Cancer Center researchers and published today in JAMA Oncology details clinical outcomes for 710 patients with brain metastases from small cell lung cancer treated with first-line stereotactic radiosurgery, without prior treatment with whole-brain radiation or prophylactic cranial irradiation.

5 Jun 2020

New analysis supports first-line stereotactic radiosurgery for small cell lung cancer

The international First-line Radiosurgery for Small-Cell Lung Cancer (FIRE-SCLC) analysis led by University of Colorado Cancer Center researchers and published today in JAMA Oncology details clinical outcomes for 710 patients with brain metastases from small cell lung cancer treated with first-line stereotactic radiosurgery (SRS), without prior treatment with whole-brain radiation (WBRT) or prophylactic cranial irradiation (PCI).

5 Jun 2020

Ludwig Cancer Research study profiles immune landscape of brain tumors

A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.

28 May 2020

Study examines 5-aminolevulinic acid induced fluorescence in surgery of brain metastases

Two-thirds of brain metastases give off fluorescence following administration of 5-aminolevulinic acid, which could potentially assist surgeons in identifying such tumors.

20 May 2020

Lung cancer medication may have benefits for patients with metastatic brain cancers

A medication commonly used to treat non-small cell lung cancer that has spread, or metastasized, may have benefits for patients with metastatic brain cancers, suggests a new review and analysis led by researchers at St. Michael's Hospital of Unity Health Toronto and Harvard Medical School.

25 Mar 2020

Novel MRI contrast agent for early detection of brain metastases

A group of researchers led by Leif Schroeder from the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent.

19 Mar 2020

UC researchers uncover potential new treatment for patients with metastatic melanoma

Researchers at the University of Cincinnati have uncovered a potentially more beneficial treatment regimen for patients with metastatic melanoma.

26 Feb 2020

NRG Oncology trial: Hippocampal avoidance during whole-brain radiotherapy reduces risks

Results from the NRG Oncology clinical study NRG-CC001 concluded that lowering radiotherapy dose to hippocampal stem cells improves cognitive and patient-reported outcomes for patients with brain metastases.

18 Feb 2020

Novel drug shows efficacy against advanced ROS1 and NTRK fusion-positive NSCLC

Pooled analysis of three phase 1 and 2 clinical trials published online ahead of print in the journal Lancet Oncology show that the drug entrectinib is effective and well-tolerated against advanced ROS1 and NTRK fusion-positive non-small cell lung cancers (NSCLC).

14 Dec 2019

First comprehensive characterization of blood-brain, blood-tumor barriers in brain metastases

The human brain has some remarkable capabilities - including the ability to block cancer drugs from effectively reaching cancer cells in the brain.

12 Nov 2019

Protein may help predict, prevent and treat brain metastases

A protein that breast, lung and other cancers use to promote their spread--or metastasis--to the brain, has been identified by a team led by Weill Cornell Medicine and New York-Presbyterian investigators. The protein, CEMIP, will now be a focus of efforts to predict, prevent and treat brain metastases, which are a frequent cause of cancer deaths.

4 Nov 2019

Two new grants to support researchers to better understand, manage metastasis of melanoma

The American Cancer Society and Melanoma Research Alliance have selected two new promising projects in a second round of funding under a partnership between ACS & MRA. The first grants funded through the partnership, in 2018, focused on advancing research to reduce side effects resulting from cancer treatments with immune-checkpoint inhibitors.

10 Oct 2019

Whole-brain radiotherapy recommended for patients with brain metastases

Patients with brain metastases who received whole-brain radiotherapy that avoided memory-specific hippocampal neural stem cells experienced preserved cognitive function and reported fewer neurologic symptoms and better cognition over time, according to results from an NRG Oncology clinical trial presented Sept. 15, 2019 at the American Society for Radiation Oncology Annual Meeting in Chicago.

20 Sep 2019

NMDAR receptor is responsible for breast-to-brain metastases, shows study

In 2018, breast cancer was the most common cancer in women worldwide, accounting for about a quarter of all reported cancers. One of the biggest problems with any type of cancer is metastasis; and when breast cancer metastasizes, the brain is a common destination.

19 Sep 2019

Study reveals how breast cancer uses exosomes to metastasize to the brain

Metastasizing breast cancers typically seek out the bones, lung, and brain. Brain metastases are especially dangerous; many women survive for less than a year after diagnosis. How is the cancer able to get past the blood brain barrier? And can it be blocked?

13 Sep 2019

Study: Blocking inflammatory pathway could prevent melanoma brain metastasis

Brain metastases are among the deadliest tumor metastases, with a median survival period of less than one year, and the incidence of brain metastasis is rising.

20 Aug 2019

New nanovaccine for deadly skin cancer

Tel Aviv scientists have published their version of a vaccine against the deadly skin cancer malignant melanoma, which arises from the pigment producing cells of the skin. This is the most feared form of skin cancer, with a high tendency to metastasize to distant parts of the body, including the brain.

6 Aug 2019

Tel Aviv researchers develop a nano-vaccine for the most aggressive skin cancer

Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer.

5 Aug 2019

Promising new approaches in the fight against brain metastasis

Research is currently pursuing several highly promising approaches in the fight against cancers that give rise to metastases in the brain.

28 Jun 2019