Bronchopulmonary Dysplasia News and Research

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Phase 2a study results of Aerosurf for prevention of RDS in premature infants published

Discovery Laboratories, Inc., announces the publication of results from its previously-conducted Phase 2a feasibility study of Aerosurf, the Company's aerosolized KL4 surfactant, for the prevention of respiratory distress syndrome in premature infants, in the May 2010 issue of the Journal of Aerosol Medicine and Pulmonary Drug Delivery in the study titled "An Open Label, Pilot Study of Aerosurf Combined with nCPAP to Prevent RDS in Preterm Neonates".

14 May 2010

Children born very early have abnormal lung function: U.K. researchers

More than half of children who were born very early—at 25 weeks or less (normal gestation is around 40 weeks)— have abnormal lung function and are twice as likely as their full-term peers to have a diagnosis of asthma, according to U.K. researchers, who followed a national cohort of extremely preterm infants to age 11.

22 Apr 2010

Human-milk diet nourishes very low-birth-weight preterm infants in NICU

Prolacta Bioscience, the first and only company to offer human milk fortifier (HMF) made from 100% human breast milk for premature and critically ill infants, has announced the results of a groundbreaking study that will have long-term benefits for the nutritional care of very low-birth-weight preterm infants (less than 2 pounds, 12 ounces or 1250 grams) in the neonatal intensive care unit (NICU).

20 Jan 2010

Small baby guidelines can improve patient outcomes and decrease the length of hospitalization

A substantial number of premature infants born before 27 weeks gestational age encounter complicated medical problems. Although the survival rate of these infants has increased over the last two decades, the survival data for these patients is highly variable.

2 Dec 2009

Human-derived UCB stem cell transplant has positive therapeutic effects on specific lung and heart disorders

Two separate studies published in the current issue of Cell Transplantation (18:8), - now freely available on-line at http://www.ingentaconnect.com/content/cog/ct - have shown that transplanted human-derived umbilical cord blood (UCB) stem cells transplanted in an animal model had positive therapeutic effects on specific lung and heart disorders the animal models.

24 Nov 2009

CTSA institutions receive NIH grants to study drug safety and efficacy in children

Studying drugs in pediatric populations is challenging because drugs often affect children differently than they do adults. The scarcity of pediatric studies limits the ability of doctors and scientists to predict drug dosing, safety and efficacy in children. To address this gap, the National Institutes of Health announced today 18 grants to help determine outcome measures and increase the likelihood of success of future trials of treatments for children.

18 Nov 2009

NIH awards The Tufts CTSI and Tufts University four supplemental grants

The Tufts Clinical and Translational Science Institute (CTSI) and Tufts University today announced they are the recipients of four supplemental grant awards from the National Institutes of Health. These new awards, totaling approximately $1.73 million, are supplements to the original Clinical and Translational Science Award (CTSA) grant, UL1 RR025752 that Tufts University received in 2008 from the National Center for Research Resources.

27 Oct 2009

New method for neonatal icus reduces infection and lung distress in preemies

A new method for improving quality of care can reduce hospital-acquired infections and chronic respiratory distress with oxygen dependency in premature infants in neonatal ICUs, according to a new study in CMAJ (Canadian Medical Association Journal).

11 Aug 2009

Estrogen activates critical lung genes to improve lung function following preterm birth

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants, researchers at UT Southwestern Medical Center have found in an animal study.

12 Mar 2009

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants

"Ironically, a hormone that has received great attention as a potential means to optimize the health of older women may be a beneficial treatment for humans during the earliest stages of life," said Dr. Philip Shaul, professor of pediatrics at UT Southwestern and the study's senior author.

12 Mar 2009

Genital mycoplasmas are a frequent cause of congenital fetal infection

Premature babies are subject to a host of threats that can result in fetal/neonatal disease.

7 Jan 2008

Gene-chip studies provide new leads in treating abnormal lung development in premature newborns

Some 20 to 40 percent of extremely premature infants suffer abnormal lung development leading to bronchopulmonary dysplasia, a chronic lung disease that can cause long-term breathing problems.

4 Oct 2007

Inhaled nitric oxide safe for very premature infants

A nationwide study led by researchers at UCSF provides evidence that inhaled nitric oxide is safe and effective for the prevention of the most common type of long-term lung disease of very premature infants.

7 Aug 2007

TGF-beta found to be a major player in causing bronchopulmonary dysplasia

Researchers from Massachusetts General Hospital, in collaboration with scientists from the Genzyme Corporation, have identified a potential treatment for a chronic lung disease affecting premature infants.

4 Apr 2007

Preemie lung treatments turn out to be safe

Preemies between 28 and 32 weeks are not harmed by a treatment no longer used to help their lungs mature before birth, according to findings of a study in this month's Pediatrics.

5 Mar 2007

Nitric oxide reduces lung disease in premature, very-low-birth-weight infants

Delivering nitric oxide to the lungs of premature, very-low-birth-weight infants during their second week of life improves their chances of surviving without chronic lung disease, according to a national study of nearly 600 babies.

26 Jul 2006

University of Alberta researchers pioneer gene therapy to restore alveoli and lung capillaries in damaged rat lungs

The good news is that medical advances in perinatal care have allowed us to save many more premature babies. The bad news is they're often at risk of developing bronchopulmonary dysplasia--a chronic lung disease caused by having to place the tiny infants on ventilators and oxygen-rich therapy for acute respiratory failure.

13 Nov 2005

Premature infants with lung disease may continue to require replacement substance to ease breathing

Physicians have known for decades that many premature babies suffer respiratory problems stemming from insufficiency of a lung substance called surfactant during their first few weeks of life.

20 Nov 2004