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New technique generates highest-resolution maps of the 3D genome

Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell.

8 May 2023

Different cellular building blocks are not produced at the same time, research shows

Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.

27 Feb 2023

Study offers novel insights into the elongation dynamics of eukaryotic cells

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of amino acid sequences taking place in the ribosomes.

5 Jan 2023

UArizona researchers discover new protein that is responsible for controlling cell growth in yeasts

Like bacteria, yeasts are found everywhere, even in and around our bodies. And, as with bacteria, you can become infected by yeasts and become ill. Yeasts infect about 150 million people a year and kill about 1.7 million, especially those who are immunocompromised.

28 Sep 2022

Researchers report the exceptional binding and neutralizing potency of an ACE2 decoy against SARS-CoV-2 variants

Researchers explored the activity of an ACE2 decoy against SARS-CoV-2 Omicron variant.

30 Aug 2022

Disrupting genes in the yeast Pichia pastori to increase its secretory production of useful proteins

A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (1) in order to increase its secretory production of useful proteins (2).

8 Jul 2022

SARS-CoV-2 3CLpro also susceptible to mutations

Researchers assess the activity of all potential mutations in the SARS-CoV-2 3CLpro.

29 Jun 2022

Most synonymous genetic mutations are strongly harmful, study shows

In the early 1960s, University of Michigan alumnus Marshall Nirenberg and a few other scientists deciphered the genetic code of life, determining the rules by which information in DNA molecules is translated into proteins, the working parts of living cells.

8 Jun 2022

Mathematical theory describes the process of checkpoint override by cells

Cells go through a life cycle that includes growing to the right size, being equipped to perform its functions, and finally dividing into two new cells.

12 May 2022

Manipulating a specific gene from yeast could lead a new approach to combatting drug resistance

A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer.

18 Apr 2022

New micro-protein supports cell division and proliferation during nutrient scarcity

Researchers from the University of Eastern Finland and the University of Montreal (Canada) have discovered that a micro-protein, which they named Nrs1, supports cell division and proliferation when nutrients are scarce.

4 Mar 2022

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria.

5 Mar 2021

Biomarkers can predict how genetically identical cells behave differently under stress

A set of biomarkers not traditionally associated with cell fate can accurately predict how genetically identical cells behave differently under stress, according to a UT Southwestern study.

8 Jan 2021

Study sheds new light on mechanisms of cohesin function involved in cancer and cardiac development

Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified cohesin in vertebrates, a protein that is essential in cell division.

12 Aug 2020

Researchers unravel key mechanisms behind the mysteries of aging

Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan.

16 Jul 2020

Study sheds light on homologous recombination of DNA strands

As chromosomes go, X and Y make an unlikely pair. The X is large and contains thousands of genes critical for life. The Y, by contrast, is little more than a nub.

29 May 2020

Study elucidates how essential amino acid in humans acts as growth signal for cells

A recent study from the Laxman lab elucidates how a small metabolite and amino acid, methionine, acts as a growth signal for cells, by setting into motion a metabolic program for cell proliferation.

7 Jan 2019

Study: Atg2 tethers pre-autophagosomal membrane to endoplasmic reticulum during autophagosome formation

Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Institute of Technology have analyzed the Atg protein Atg2, whose function had been completely unknown, and have discovered that Atg2 tethers the pre-autophagosomal membrane to the endoplasmic reticulum during autophagosome formation.

23 Oct 2018

Study links cell size with commitment to division

How does a cell know when to divide? We know that hundreds of genes contribute to a wave of activity linked to cell division, but to generate that wave new research shows that cells must first grow large enough to produce four key proteins in adequate amounts.

24 May 2018

Researchers discover glutamine-dependent activation of cell growth and autophagy

The human body consists of about 35 trillion cells, so it could be said that overall body growth is the growth of individual cells.

3 May 2018