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Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

In a recent study posted to the bioRxiv* preprint server, researchers in Italy and the United States evaluated the efficacy and immunogenicity of an adjuvanted tetravalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit 1 (S1) COVID-19 vaccine.

21 Mar 2023

Childhood common colds help protect against COVID-19

In a recent study published in the Proceedings of the National Academy of Sciences, researchers assessed the association between cross-reactive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) CD4+ T cells generation and age.

20 Mar 2023

SARS-CoV-2 infection damages the CD8+ T cell response to vaccination

The magnitude and quality of a key immune cell's response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found.

20 Mar 2023

Biomarkers that can predict long COVID symptoms

The current study offered novel insights into the different biological factors that might contribute to long COVID.

19 Mar 2023

Ipsilateral vaccination improves response to second dose of COVID-19 vaccine

Researchers examine whether the involvement of the ipsilateral or contralateral lymph nodes affected the immune response during sequential vaccination.

16 Mar 2023

Analyzing regulatory and effector T cells in tumors

In this interview, Cerba Research describes how its teams were able to detect resident memory T cells in solid tumors thanks to multiplex immunofluorescence.

From Cerba Research 16 Mar 2023

Children's immunity to COVID-19 provided by common colds

During the pandemic, it became clear that children who contracted COVID-19 became less ill than adults.

15 Mar 2023

Lassa virus vaccine induces rapid protection in an animal model

Scientists have developed a novel Lassa vaccine using a recombinant measles virus and tested its protective efficacy against Lassa fever. A single vaccine dose has been found to induce a rapid and robust immune response in monkeys with pre-existing immunity against the measles virus.

14 Mar 2023

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Researchers observe persistent SARS-CoV-2 replication in severe COVID-19 patient lungs.

13 Mar 2023

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

Researchers assessed the impact of an anti-CD3 monoclonal antibody called Foralumab in COVID-19 treatment.

9 Mar 2023

How does chronic HBV infection affect flu and COVID-19 vaccine responses?

The influenza season marks the beginning of a time of illness, sometimes serious or even fatal, in much of the world. For this reason, flu shots are recommended, especially for individuals with underlying diseases such as chronic hepatitis B (CHB) infection, since they are at higher risk for adverse outcomes.

6 Mar 2023

Study finds cannabis vaping more harmful than nicotine vaping

A study published in the journal Thorax compares the pulmonary effects of vaping nicotine and cannabis. The study finds that cannabis is more harmful to lung health than nicotine.

5 Mar 2023

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

In a recent study published in Cells, researchers evaluated idiopathic pulmonary fibrosis (IPF) pathophysiological differences by sex and intestinal microbiome.

1 Mar 2023

Mass spectrometry-based identification of COVID-19 biomarkers

In a recent study published in the journal Metabolites, researchers reported that mass spectrometry (MS)-based metabolomic approaches have a high potential for biomarker discovery.

28 Feb 2023

HIV creates reservoirs much earlier than expected, study shows

For the first time in humans, a research team has shown that, as early as the first days of infection, HIV is able to create reservoirs where it will hide and persist during antiretroviral therapy.

28 Feb 2023

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Researchers immunophenotyped T lymphocyte responses among unvaccinated individuals, representative of the entire spectrum of the clinical presentation of COVID-19.

28 Feb 2023

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Researchers assessed T-cell tolerance checkpoints observed in atherosclerosis.

27 Feb 2023

Exploring Mpox severity among advanced HIV patients

Researchers assessed the incidence of mpox in individuals with advanced human immunodeficiency virus (HIV) infection.

24 Feb 2023

Scientists identify mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

22 Feb 2023

Dietary polyphenols may play a role in regulating inflammatory immune responses

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

22 Feb 2023

CD4 News and Research

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

Childhood common colds help protect against COVID-19

SARS-CoV-2 infection damages the CD8+ T cell response to vaccination

Biomarkers that can predict long COVID symptoms

Ipsilateral vaccination improves response to second dose of COVID-19 vaccine

Analyzing regulatory and effector T cells in tumors

Children's immunity to COVID-19 provided by common colds

Lassa virus vaccine induces rapid protection in an animal model

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Nasal administration of a fully human anti-CD3 monoclonal antibody modulates T cell inflammatory responses in COVID-19

How does chronic HBV infection affect flu and COVID-19 vaccine responses?

Study finds cannabis vaping more harmful than nicotine vaping

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

Mass spectrometry-based identification of COVID-19 biomarkers

HIV creates reservoirs much earlier than expected, study shows

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Exploring Mpox severity among advanced HIV patients

Scientists identify mechanisms underlying autoimmunity in Down syndrome

Dietary polyphenols may play a role in regulating inflammatory immune responses

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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