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Using 'organs-on-a-chip' to study chronic inflammatory diseases

MIT biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system, on a specialized microfluidic platform seeded with human cells.

18 Mar 2020

Immunotherapy combination can shrink viral reservoir in HIV model

Stimulating immune cells with two cancer immunotherapies together can shrink the size of the viral "reservoir" in SIV-infected non-human primates treated with antiviral drugs, researchers have concluded.

16 Mar 2020

Exploring the biological link between reactivated HSV and neurological disease

Without even knowing it, most of us carry around latent Herpes Simplex Virus in our nervous system- a simple result of being born and living together with others carrying the virus.

10 Mar 2020

Study reports second ever case of a patient to be cured of HIV

A study of the second HIV patient to undergo successful stem cell transplantation from donors with a HIV-resistant gene, finds that there was no active viral infection in the patient's blood 30 months after they stopped anti-retroviral therapy, according to a case report published in The Lancet HIV journal and presented at CROI.

10 Mar 2020

Immune systems of preemies can catch up

According to a new study published in March 2020 in the journal Nature Communications, babies born prematurely up to 32 weeks of pregnancy can quickly catch up on their immune system function after birth, bringing them to a state comparable to term infants.

9 Mar 2020

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Patients with autoimmune diseases like multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis have an imbalance between two types of immune system T cells.

26 Feb 2020

New study uncovers human genes controlling HIV infection

Viruses are parasites. The only way they can grow is by hijacking their hosts. When they infect a human host, viruses use human proteins to multiply and modify the human cells to sustain the infection. At the same time, the human host activates defense mechanisms to fight the infection.

20 Feb 2020

Measles re-emerging globally

Measles is a common childhood illness but can cause more than a passing fever with rash. It could turn out to be a complicated and severe illness, warn doctors in a new paper published in February 2020 in the journal BMJ Case Reports.

17 Feb 2020

Blue Water Vaccines enters into agreement to develop Streptococcus pneumoniae vaccine with St. Jude

Blue Water Vaccines Inc., a biopharmaceutical company focused on creating transformative vaccines solving global health challenges, has entered into an exclusive worldwide license agreement for the development of a Streptococcus Pneumoniae vaccine with St. Jude Children's Research Hospital, the nation's leading hospital dedicated to understanding, treating and curing childhood cancer and other life-threatening diseases.

11 Feb 2020

HIV antibody therapy improves immune function

A new study published in the journal Nature Medicine in February 2020 reports that the administration of neutralizing antibodies against HIV improve the recipient’s specific T cell responses against the virus.

3 Feb 2020

New study gives hope for potentially developing a cure for HIV

HIV latency is considered one of the biggest challenges to developing a cure for the virus.

23 Jan 2020

Scientists reverse HIV latency, take major scientific step toward curative therapies

Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells.

22 Jan 2020

Smoking dormant HIV virus out into the open to develop a cure

Ever since antiretroviral treatments against HIV infection were introduced in 1996, scientists have eagerly been hunting for a cure for the disease.

9 Jan 2020

Immune cells could help kill cancer cells, finds study

Researchers from UCL Cancer Institute have found that a subset of immune cells can kill cancer cells when activated.

8 Jan 2020

Immune cell discovery could hold the key to effective therapies against cancer

Scientists at UCL have identified how a subset of immune cells are activated to kill cancerous cells, a finding in mice which could hold the key to new powerful therapies against cancer.

7 Jan 2020

ART may not be completely effective in restoring immune protection, study suggests

A study led by researchers from SUNY Downstate Health Sciences University and Oregon Health & Science University, published in the Journal of Infectious Diseases, showed that, despite successful antiretroviral therapy, antigen specific memory to vaccinations that occurred before HIV infection did not recover, even after immune reconstitution.

6 Jan 2020

CD4 T cells are not to be blamed for pushing dengue fever from bad to worse

No one knows what makes a mild dengue viral infection morph into a severe and sometimes deadly dengue hemorrhagic fever/dengue shock syndrome.

26 Dec 2019

New mechanism that impairs Treg differentiation and stability in type 1 diabetes discovered

Regulatory T cells (Tregs) prevent excessive immune reactions in healthy people. In the development of autoimmune type 1 diabetes, this protection is not sufficiently effective.

19 Dec 2019

Study finds new drivers of destructive inflammation

Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases.

17 Dec 2019

The sympathetic nervous system can modulate action of defense cells in autoimmune disease

The results of a study conducted in Brazil suggest that the sympathetic nervous system - the part of the autonomous nervous system that controls responses to danger or stress - can modulate the action of defense cells in patients with autoimmune diseases.

16 Dec 2019