CD4 News and Research

RSS

mRNA rabies vaccine induces durable immune response in macaques

Novel mRNA vaccine for rabies shows enhanced immune response with higher antibody levels and improved cross-neutralization, indicating potential for a broadly protective vaccine against related lyssavirus strains.

26 Jun 2023

Scientists identify potential biomarkers associated with positive immunotherapy response

Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified potential new biomarkers that could indicate how someone diagnosed with metastatic melanoma will respond to immunotherapy treatment.

26 Jun 2023

Scientists discover new way to defeat invisible cancer cells

Modern immunotherapies boost the body's own defenses against cancer. They activate killer T cells of the immune system that can specifically recognize and destroy cancer cells.

23 Jun 2023

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Study describes the use of engineered commensal bacteria to increase antitumor immunity.

23 Jun 2023

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Allogeneic stem cell transplantation with CCR5Δ32/Δ32 donors shows potential for HIV cure. Alloimmunity and CCR5 deficiency play significant roles in viral reservoir clearance.

19 Jun 2023

Brain microglia serve as a stable viral reservoir for latent HIV

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, latent state for a long period of time, which is referred to as HIV latency.

16 Jun 2023

Penn research bolsters scientific understanding behind why some people are more prone to allergies

New research is bolstering scientific understanding behind why some people are more prone to allergies than others.

15 Jun 2023

Unlocking the secret to lifelong health: the power of optimal immune resilience

Researchers assessed immune resilience (IR) metrics in individuals across diverse infectious and non-infectious models.

15 Jun 2023

Stronger defense: symptomatic malaria provides durable protection against reinfection

Researchers evaluated the immune protection conferred by symptomatic and asymptomatic P. falciparum.

14 Jun 2023

Immune resilience promotes longevity and resistance to infections

Researchers from The University of Texas Health Science Center at San Antonio, working with collaborators in five countries, today revealed that the capacity to resist or recover from infections and other sources of inflammatory stress -; called "immune resilience" -; differs widely among individuals.

13 Jun 2023

Antiretroviral treatment efficiently suppresses penile HIV replication

Of the 38 million people worldwide living with HIV, approximately 700,000 are newly infected men, primarily via sexual transmission.

12 Jun 2023

Study raises new hopes for blood cancer patients with an incomplete response to CAR T cell therapy

The aim of immunotherapy strategies is to use cells in the patient's own immune system to destroy tumor cells. CAR T cell therapy is an immunotherapy that is effective in treating blood cancer.

12 Jun 2023

Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Two new studies in Science and Science Immunology spotlight a group of intestinal T cells with α4β7 integrin receptors that could be targeted to prevent resistance to immune checkpoint blockade (ICB) cancer immunotherapy.

8 Jun 2023

Scientists identify the IL-17 protein as a determining factor in skin aging

A team of scientists from the Institute for Research in Biomedicine (IRB Barcelona) in collaboration with the National Center for Genomic Analysis (CNAG) has discovered that IL-17 protein plays a central role in skin aging.

8 Jun 2023

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide -; with almost a third in the United States -; are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.

6 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Scientists investigate how immune system's T cells could fight many coronaviruses at once

Scientists at La Jolla Institute for Immunology (LJI) are investigating how the immune system's T cells react to a wide variety of coronaviruses, ranging from SARS to common cold coronaviruses.

1 Jun 2023

Key insights into immune responses after COVID-19 vaccination in Indigenous people

Researchers evaluated immune responses to COVID-19 BNT162b2 mRNA vaccinations among Indigenous Australian First Nations (FN) individuals by comorbidity and ethnicity.

1 Jun 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

New method may help identify the essential ingredients for making an effective HIV vaccine

Since it was identified in 1984 as the cause of Acquired Immune Deficiency Syndrome (AIDS), the human immunodeficiency virus (HIV) has infected more than 80 million people and been responsible for some 40 million deaths worldwide, according to the World Health Organization (WHO).

30 May 2023