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HIV vaccine trial volunteers asked to undergo testing to determine whether they are at increased risk of HIV

Researchers have asked more than 3,000 people who participated in a trial of Merck's experimental HIV vaccine that was halted last month to undergo additional testing to determine if they are at an increased risk of HIV, Reuters reports (Fox, Reuters, 10/25).

29 Oct 2007

HIV combination antiretroviral drug therapy key to saving the lives of African children

Letting nurses and other trained health care workers deliver that therapy and monitor patients, especially when doctors are in short supply, is just as important to saving lives, according to a new study by the University of Alabama at Birmingham (UAB).

24 Oct 2007

Stanford seeks volunteers for flu vaccine study

Researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital are looking for adults and children to participate in three studies that will help them better understand how the flu vaccine works in people of different ages.

22 Oct 2007

Genetic influence on HIV/AIDS progression

Viral load - the amount of virus in the blood of an HIV-infected person - has long been viewed as the chief indicator of how quickly someone infected with HIV infection progresses to AIDS.

22 Oct 2007

Critical need for earlier diagnosis and referral of HIV-infected children in Africa

Care provided by nurses and other clinicians in primary health care settings in sub-Saharan Africa can result in good outcomes for children with HIV infection.

22 Oct 2007

Good outcomes possible for HIV-infected children in Africa enrolled in pediatric treatment programs

Care provided by nurses and other clinicians in primary health care settings in sub-Saharan Africa can result in good outcomes for children with HIV infection.

22 Oct 2007

FDA approves raltegravir new HIV drug

The U.S. Food and Drug Administration (FDA) has approved raltegravir tablets for treatment of Human Immunodeficiency Virus (HIV)-1 infection in combination with other antiretroviral agents in treatment-experienced adult patients who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.

17 Oct 2007

Low prevalence of Helicobacter pylori in HIV-positive patients

Helicobacter pylori has been extensively studied and proven to be the main cause of chronic gastritis and peptic ulcer in the HIV-negative population.

17 Oct 2007

Second pathway behind HIV-associated immune system dysfunction identified

Researchers at the Partners AIDS Research Center at Massachusetts General Hospital (PARC-MGH) may have discovered a second molecular "switch" responsible for turning off the immune system's response against HIV.

1 Oct 2007

microRNAs may be key to HIV's ability to hide, evade drugs

Tiny pieces of genetic material called microRNA (miRNA), better known for its roles in cancer, could be a key to unlocking the secrets of how HIV, the AIDS virus, evades detection, hiding in the immune system.

1 Oct 2007

Acute loss of intestinal CD4+ T cells is not predictive of SIV virulence

A sudden loss of T cells -- white blood cells crucial to the immune system -- is not the trigger for the onset of AIDS, according to a study published in the September 2007 issue of the Journal of Immunology by a team of researchers at Tulane National Primate Research Center.

24 Sep 2007

Pregnancy may slow AIDS progression

A new study may help put to rest fears that pregnancy accelerates progression to full-blown AIDS in women with HIV receiving antiretroviral therapy.

20 Sep 2007

HIV patients with declining platelet counts appear to be at increased risk for HIV-associated dementia

Therapies leading to longer life for HIV patients have paradoxically increased the prevalence of this condition. Identifying biological markers for the development of HIV–associated dementia is critical both for diagnosing the disorder and for understanding its underlying mechanisms.

11 Sep 2007

New insights into the complexity of HIV/AIDS

Three related papers published in the Sept. 1 edition of The Journal of Immunology provide key new insights into the complexity of HIV/AIDS. Don Sodora, Ph.D., a principal investigator in SBRI's Viral Vaccines Program who recently joined SBRI from the University of Texas, Southwestern Medical Center, is senior author on one of three papers that collectively show CD4 T-cell depletion, a critical symptom of AIDS, is likely a part of a multifaceted scenario that triggers disease rather than the only cause.

10 Sep 2007

New studies emphasize need for influenza and measles vaccinations in HIV-infected patients

Two new studies emphasize the importance of delivering measles and influenza vaccines to HIV-infected individuals.

24 Jul 2007

Long term antiretroviral therapy may restore CD4 cell counts in HIV positive patients

HIV positive patients who take combination antiretroviral therapy (cART) to combat HIV infection could see the numbers of CD4 cells in their immune system rise to concentrations found in HIV negative individuals, if they remain on the therapy for long enough and their HIV viral load load is suppressed to below 50 copies per ml.

20 Jul 2007

Orchestra Therapeutics discontinues HIV vaccine program

Orchestra Therapeutics, Inc. has announced the discontinuation of its HIV Vaccine Development Program.

18 Jul 2007

Co-infection of HIV and HCV a significant health concern due to increasing prevalence

Researchers at Boston Medical Center (BMC) and Boston University School of Public Health (BUSPH) have found that persons infected with the human immunodeficiency virus (HIV), who also have alcohol problems, were negatively affected by co-infection with the hepatitis C virus (HCV).

28 May 2007

Natural immune-control system may aid treatment of autoimmune disease and tissue rejection

The immune system's ability to police itself may offer a new method of arresting the cells responsible for autoimmune diseases such as multiple sclerosis and for the rejection of transplanted organs and tissues, scientists at Dana-Farber Cancer Institute report in a study in the May issue of the journal Immunity.

18 May 2007

Quest for effective HIV vaccines present new possibilities, challenges

A vaccine that prevents HIV infection remains an important goal in the fight against AIDS, but the current top HIV vaccine candidates may not work in this way, say scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

17 May 2007

CD4 News and Research

HIV vaccine trial volunteers asked to undergo testing to determine whether they are at increased risk of HIV

HIV combination antiretroviral drug therapy key to saving the lives of African children

Stanford seeks volunteers for flu vaccine study

Genetic influence on HIV/AIDS progression

Critical need for earlier diagnosis and referral of HIV-infected children in Africa

Good outcomes possible for HIV-infected children in Africa enrolled in pediatric treatment programs

FDA approves raltegravir new HIV drug

Low prevalence of Helicobacter pylori in HIV-positive patients

Second pathway behind HIV-associated immune system dysfunction identified

microRNAs may be key to HIV's ability to hide, evade drugs

Acute loss of intestinal CD4+ T cells is not predictive of SIV virulence

Pregnancy may slow AIDS progression

HIV patients with declining platelet counts appear to be at increased risk for HIV-associated dementia

New insights into the complexity of HIV/AIDS

New studies emphasize need for influenza and measles vaccinations in HIV-infected patients

Long term antiretroviral therapy may restore CD4 cell counts in HIV positive patients

Orchestra Therapeutics discontinues HIV vaccine program

Co-infection of HIV and HCV a significant health concern due to increasing prevalence

Natural immune-control system may aid treatment of autoimmune disease and tissue rejection

Quest for effective HIV vaccines present new possibilities, challenges

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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