CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

COVID-19 vaccine safety concerns result in lower vaccination rates among pregnant individuals in the United States

In a new study, researchers evaluated the factors associated with lower coronavirus disease 2019 (COVID-19) vaccination rates among pregnant individuals in the United States (U.S.).

15 Sep 2022

Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

Significant improvement in progression-free survival and response rate combined with reduced symptoms and better quality of life are reported as outcomes of a new treatment approach for patients with desmoid tumors, which are benign, but locally aggressive and invasive soft tissue tumors.

12 Sep 2022

Researchers explore whether non-monetary benefits can improve NHS nursing staff retention

The House of Commons Committee on Health and Social Care recently described the NHS as being in the grip of the "greatest workforce crisis in its history", which is likely to have serious consequences for patient care.

7 Sep 2022

New OCTARAY™ Mapping Catheter with TRUEref™ Technology from Biosense Webster

The OCTARAY™ Mapping Catheter with TRUEref™ Technology provides physicians with the precise information needed for catheter ablation procedures that treat cardiac arrhythmias.

From Johnson & Johnson 7 Sep 2022

New study estimates how long people with mild COVID-19 are infectious

A new study of 57 people with mild COVID-19 estimates how long people are infectious for and when they can safely leave isolation.

19 Aug 2022

Study highlights the lack of evidence-based clinical management guidelines for monkeypox

A dearth of high quality, up to date clinical guidance on monkeypox may be hampering effective and safe treatment of the infection around the world, concludes a review of what's available to guide patient care and published in the open access journal BMJ Global Health.

18 Aug 2022

New method can modify an entire substance class of medically relevant natural products

The use of the element fluorine to modify active substances is an important tool in modern drug development.

5 Aug 2022

Study explores experiences of speech and language therapists using voice-assisted technology

JMIR Publications recently published "Speech and Language Practitioners' Experiences of Commercially Available Voice-Assisted Technology: Web-Based Survey Study" in JMIR Rehabilitation and Assistive Technologies which reported the professional experiences of UK speech and language therapists using voice-assisted technology (VAT) (e.g. Alexa, Siri) with their clients to identify the potential applications and barriers to VAT adoption and thereby inform future directions of research.

2 Aug 2022

Insights into molecular folding of AAT protein will help develop new therapies for alpha-1 antitrypsin deficiency

In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass Chan Medical School recently announced that they have mapped the expression and maturation of the protein alpha-1 antitrypsin (AAT) with unprecedented clarity.

25 Jul 2022

FTC official: Antitrust push in health care must focus on a merger’s ‘human impact’

President Joe Biden has ordered the Federal Trade Commission to combat consolidation in the health care industry, saying that it is driving up prices for consumers and limiting their access to care.

18 Jul 2022

New insights on measuring and valuing children's health-related quality of life

Value in Health, the official journal of ISPOR-;the professional society for health economics and outcomes research, announced today the publication of a series of articles providing new insights on measuring and valuing children's health-related quality of life.

5 Jul 2022

LA’s first heat officer says helping vulnerable communities is key to achieving climate goals

As a child growing up in San Jose, California, Marta Segura heard horrific stories from her parents about women fainting on the factory lines and men overheating in the farm fields.

1 Jul 2022

New word-score model can estimate the amount of hidden hearing loss in human ears

Researchers from Mass Eye and Ear have developed a word-score model capable of estimating the amount of hidden hearing loss in human ears.

28 Jun 2022

American College of Radiology issues risk mitigation strategies to address contrast media shortage

GE Healthcare was forced to shut a production plant in April because of a COVID-19 outbreak in Shanghai, China.

23 Jun 2022

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

Lawmaker takes on insurance companies and gets personal about his health

Scott Wiener made a startling revelation at a spring legislative committee hearing: "I was in the hospital. I experienced the most intense abdominal pain that I could even imagine."

9 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Review sets out new plans to create the biggest shake-up in health and social care leadership

The Health and Social Care Secretary Sajid Javid has welcomed the publication of an independent review of health and adult social care leadership, led by General Sir Gordon Messenger and Dame Linda Pollard - and, in what will be the biggest shake-up in health and social care leadership in a generation, is accepting all seven transformative recommendations they have put forward.

7 Jun 2022

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

A large randomized, placebo-controlled clinical trial led by the National Institutes of Health shows that treating adults hospitalized with COVID-19 with infliximab or abatacept - drugs widely used to treat certain autoimmune diseases - did not significantly shorten time to recovery but did substantially improve clinical status and reduce deaths.

2 Jun 2022

New digital tool provides effective support for the treatment of pediatric obesity

A mobile app that shows a child's weight development in real-time for children with obesity provides greater weight loss compared to conventional care.

31 May 2022