Caenorhabditis elegans News and Research

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Caenorhabditis elegans is a free-living, transparent nematode (roundworm), about 1 mm in length, which lives in temperate soil environments.

Research could lead to new non-antibiotic drugs to counter hospital infections

Lack of an adequate amount of the mineral phosphate can turn a common bacterium into a killer, according to research to be published in the April 14, 2009, issue of the Proceedings of the National Academies of Science.

9 Apr 2009

Scientists show how a neuron gets its shape

Ask a simple question, get a simple answer: When Abraham Lincoln was asked how long a man's legs should be, he absurdly replied, "Long enough to reach the ground."

6 Apr 2009

Researchers cast doubt on role of free radicals in aging

For more than 40 years, the prevailing explanation of why we get old has been tied to what is called oxidative stress.

18 Feb 2009

Neural wiring hints at nervous system gene limits

Genetics may play a surprisingly small role in determining the precise wiring of the mammalian nervous system, according to painstaking mapping of every neuron projecting to a small muscle mice use to move their ears.

16 Feb 2009

Scientists unlock secrets of gene regulatory networks

A quartet of studies by researchers at the California Institute of Technology (Caltech) highlight a special feature on gene regulatory networks recently published in the Proceedings of the National Academy of Sciences ( PNAS ).

3 Feb 2009

Studies offer guide as protein interaction mapping comes of age

During the past 20 years, researchers have identified thousands of cell protein interactions, with the ultimate goal of inventorying all that occur within cells of various organisms - a comprehensive catalogue known as the interactome.

6 Jan 2009

C. elegans worms may hold key to new treatments for obesity in humans

A previously unknown mutation discovered in a common roundworm holds the promise of new treatments for obesity in humans, McGill University researchers say.

8 Dec 2008

New insights into cell division

Biologists have discovered a mechanism that is critical to cytokinesis -- nature's completion of mitosis, where a cell divides into two identical daughter cells.

5 Dec 2008

Without glial cells, animals lose their senses

Sensory neurons have always put on a good show. But now it turns out they'll be sharing the credit. In groundbreaking research to appear in the October 31 issue of Science, Rockefeller University scientists show that while neurons play the lead role in detecting sensory information, a second type of cell, the glial cell, pulls the strings behind the scenes.

3 Nov 2008

Beyond recognizing odors, a single neuron controls reactions

Babies will smile when they catch the scent of vanilla, but a whiff of rotting meat will send them into fits. From people to mice and flies to worms, animals of all kinds are born with likes and dislikes thanks to the evolutionary wisdom collected in their genes. But new research shows that some preferences are still surprisingly flexible at even the most basic level - that of the sensory neuron itself - and that our nervous system may be even more adaptable than we thought.

20 Oct 2008

Research finds genes and processes that may underlie what makes some people more susceptible to Parkinson's disease

Better understanding of Parkinson's disease onset during aging is important for improving diagnostics and developing strategies for therapeutic intervention.

24 Mar 2008

Worm defecation holds clues to widespread cell-to-cell communication process

The focus of two recent Nobel prizes, a species of roundworm has made possible another advance in the understanding of how cells talk to one another, according to a study published online Feb. 21 in the journal Current Biology.

22 Feb 2008

New devices to boost nematode research on neurons and drugs

A pair of new thin, transparent devices, constructed with soft lithography, should boost research in which nematodes are studied to explore brain-behavior connections and to screen new pharmaceuticals for potential treatment of parasitic infections in humans, report 10 scientists at three institutions.

7 Feb 2008

Overexcited neurons not good for cell health

Neurotransmitters have consequences. They initiate events that are critical to a healthy life, giving us the ability to move, to talk, to breathe, to think. But that's if the neurotransmitters are getting it right and sending proper signals downstream to muscle cells, neurons or other cells.

18 Dec 2007

Antidepressant drug mianserin extends the lifespan of adult roundworms

A team of scientists led by Howard Hughes Medical Institute (HHMI) investigator Linda B. Buck has found that a drug used to treat depression can extend the lifespan of adult roundworms.

21 Nov 2007

New gene findings show that controls of lifespan and cancer have deep, common roots

A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported in the journal "Nature Genetics" identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm.

15 Oct 2007

Avoiding sweets may spell a longer life

A new study in the October issue of Cell Metabolism, a publication of Cell Press, reveals that worms live to an older age when they are unable to process the simple sugar glucose.

3 Oct 2007

Brugia malayi's secrets revealed

An international team of researchers has revealed the genetic secrets of one of the world's most debilitating human parasites, Brugia malayi (B. malayi), which the World Health Organization estimates has seriously incapacitated and disfigured more than 40 million people around the globe.

21 Sep 2007

Process of necrosis redefined in landmark study

A new study led by investigators from the University of Pittsburgh School of Medicine demonstrates that the process of necrosis, long thought to be a chaotic, irreversible pathway to cell death, may actually be triggered as part of a regulated response to stress by a powerful protein, SRP-6, that can potentially halt necrosis in its path.

21 Sep 2007

Mechanism for the in-vivo transport of siRNA

It all started with flowers: in the nineties of the last century Norwegian researchers discovered that additional copies of a particular gene in petunias inhibited its activity instead of reinforcing it as had been assumed.

18 Sep 2007