Caenorhabditis elegans is a free-living, transparent nematode (roundworm), about 1 mm in length, which lives in temperate soil environments.
A professor at Worcester Polytechnic Institute is exploring aging on the molecular level, examining how the lipids found in our bodies, particularly those in our cell membranes, change as we age, and how those changes may affect bone and muscle strength, brain health, and our propensity for age-related diseases, including Alzheimer's disease.
A team of researchers led by Principal Investigator Dr Jan Gruber from Yale-NUS College has discovered a combination of pharmaceutical drugs that not only increases healthy lifespan in the microscopic worm Caenorhabditis elegans (C. elegans), but also delays the rate of ageing in them, a finding that could someday mean longer, healthier lives for humans.
A new study suggests that if the epigenetics of sperm chromosomes are altered by the environment a father experiences, then this could affect offspring’s health.
The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibers responsible for the onset of Parkinson's disease, and reverts the neurodegeneration caused by the disease.
Scientists stunted the puberty of male worms by starving them before they underwent sexual maturation. In a study funded by the National Institutes of Health, the scientists suggested that stress from starvation even days before sexual maturation prevented normal changes in the wiring patterns of key neuronal circuits, which caused adult male worms to act immature.
Researchers at Nagoya University have identified the series of molecules involved in the regeneration of damaged nerves in roundworm, showing that it largely overlaps with the signals used by the intrinsic removal system to take up and process dying cells.
Through a study of roundworm nerve cells with severed axons, researchers at Nagoya University showed that a signaling cascade that normally functions in promoting the phagocytosis of apoptotic cells also acts in inducing axon regeneration.
Studying transthyretin amyloidoses-;a group of progressive nerve and cardiac degenerative diseases caused by the buildup of misfolded transthyretin proteins in the body-;has long been hampered by the lack of animal models of the disease.
The bacterium Vibrio cholerae was discovered more than 150 years ago but remains as one of the main causes of bacterial infectious disease globally, especially in low-income nations where it occurs endemic, and outbreaks of cholera disease can lead to major epidemics.
Researchers have identified a new inherited neurodevelopmental disease that causes slow growth, seizures and learning difficulties in humans.
Ask a dozen people about their greatest fears, and you'll likely get a dozen different responses. That, along with the complexity of the human brain, makes fear--and its close cousin, anxiety--difficult to study.
Women have been told for years that if they don't have children before their mid-30s, they may not be able to. But a new study from Princeton University's Coleen Murphy has identified a drug that extends egg viability in worms, even when taken midway through the fertile window, which could theoretically extend women's fertility by three to six years.
A new research study reveals RAC1 protein could be a new therapeutic target to study the molecular mechanisms related to the neurodegenerative processes in Parkinson's disease.
Researchers at the University of Michigan Life Sciences Institute found that a previously dismissed genetic mechanism may contribute to nicotine dependence, and to the withdrawal effects that can make quitting smoking so difficult.
Monash University scientists are one step closer to solving the riddle of how nerves can self-heal. The scientists from the Biomedicine Discovery Institute (BDI) have found signals in the tiny transparent roundworm that control the mechanism by which severed nerves self-heal.
Environmental health scientist Alicia Timme-Laragy at the University of Massachusetts Amherst recently received a $1.9 million grant from the National Institute of Environmental Health Sciences to study the health effects of two environmental pollutants, perfluoro-octanesulfonic acid (PFOS) and its recent replacement chemical, perfluoro-butanesulfonic (PFBS).
Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals.
Two recent Northwestern University studies shed new light on the mystery of the leading cause of birth defects and miscarriage, laying the foundation for further research in an understudied but crucially important field of genetic study.
The heredity substance DNA is the blueprint of our life. Like an instruction manual it contains all the information needed for cells and the body to function properly.
Regular exercise is considered an important form of treatment for heart failure, a condition in which the heart is unable to pump enough blood to meet the body's needs.