Caenorhabditis elegans News and Research

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Caenorhabditis elegans is a free-living, transparent nematode (roundworm), about 1 mm in length, which lives in temperate soil environments.

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

A research team led by Dr Karen Wing Yee YUEN, Associate Professor from the School of Biological Sciences at the University of Hong Kong (HKU), revealed the mechanism of artificial chromosome (AC) formation in the embryos of the model organism Caenorhabditis elegans, a 1-mm long, transparent nematode.

18 Oct 2021

New scent test for early detection and diagnosis of pancreatic cancer

Oncotarget published "Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer" which reported that although early detection and diagnosis are indispensable for improving the prognosis of patients with pancreatic cancer, both have yet to be achieved.

11 Oct 2021

Researchers discover unique self-destructive process in aging nematode worms

As worm mothers age, they secrete a milk-like fluid through their vulva that is consumed by their offspring and supports their growth, according to a new study led by UCL researchers.

6 Oct 2021

Research reveals nucleolar RNA interference based on C. elegans as a model organism

A research group led by Prof. GUANG Shouhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. FENG Xuezhu from the First Affiliated Hospital of USTC, revealed the nucleolar RNA interference based on Caenorhabditis elegans (C. elegans) as a model organism. The study was published in Nuclear Acids Research.

28 Sep 2021

Design of mRNA vaccines to combat COVID-19

A recent review study discusses fundamental concepts in the successful delivery of nucleic acids in therapeutics.

23 Sep 2021

Salt tasting cells drive food foraging strategy in nematode worms

Neuroscientists have developed a computer model to explain how a nematode worm searches for food, revealing that single brain cells can both sense the environment and control a whole animal's foraging strategy.

9 Sep 2021

Study sheds light on neurologic symptoms caused by SARS-CoV-2 infection

Researchers in Australia and Finland have provided important insights into how infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – might affect nervous system circuitries and cause neurologic symptoms.

6 Sep 2021

HKU research team sheds critical insight on what causes abnormal embryo elongation

Fetal abnormalities are of concern to all prospective parents, and many of these problems originate from abnormalities in the development of the embryo particularly during its elongation and division.

10 Aug 2021

Researchers use tiny worm to trace the development of human brain

Researchers at Sinai Health have used a tiny worm to track how an animal’s brain changes throughout its lifetime, shedding new light on how human brains develop.

5 Aug 2021

Mating can turn off a single gene for multiple generations, study shows

Evidence suggests that what happens in one generation--diet, toxin exposure, trauma, fear--can have lasting effects on future generations.

9 Jul 2021

Precise manipulation of folate metabolism may pave way to broadly improve health during aging

Several different causes of aging have been discovered, but the question remains whether there are common underlying mechanisms that determine ageing and lifespan.

16 Jun 2021

UTokyo researchers study worms to understand the neuroplasticity of learning

As anyone who has ever procrastinated knows, remembering that you need to do something and acting on that knowledge are two different things. To understand how learning changes nerve cells and leads to different behaviors, researchers studied the much simpler nervous system of worms.

1 Jun 2021

Study sheds new light on complex dynamics involved in microbial infections

Included in the vast fallout stemming from the COVID-19 pandemic, scientists are paying closer attention to microbial infections and how life forms defend against attacks from pathogens.

27 May 2021

Fasting diets could have detrimental effect on the health of future generations

Fasting diets could impact the health of future generations according to new research from the University of East Anglia (UEA).

17 May 2021

New approach to scale up genome editing in tiny worms

Understanding the effects of specific mutations in gene regulatory regions - the sections of DNA and RNA that turn genes on and off - is important to unraveling how the genome works, as well as normal development and disease.

13 Apr 2021

Highly sensitive DNA nanosensor can accurately detect lethal superbugs

The persistent overuse of antibiotics has led to the evolution of antibiotic resistant pathogens, or “superbugs,” which can cause severe life-threatening infections that must be diagnosed and treated early on.

23 Mar 2021

Scientists study seven human coronavirus envelope proteins using topology prediction and molecular modeling

A new study by researchers at the University of the Western Cape aimed to determine why some coronaviruses are more virulent than others. The team speculates that the increased flexibility of the PDZ-binding motif (PBM) of SARS-CoV, MERS-CoV, and SARS22 CoV-2 to be more flexible than the PBM of hCoVs 229E, NL63, OC43, and HKU1.

9 Mar 2021

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria.

5 Mar 2021

New transcriptome‐based aging clock reads the biological age of an organism

Using the model organism Caenorhabditis elegans, researchers at the University of Cologne have developed an 'aging clock' that reads the biological age of an organism directly from its gene expression, the transcriptome.

3 Mar 2021

Sulforaphane prolongs lifespan and healthspan of C. elegans through insulin/IGF-1 signaling

Aging-US published "Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling" which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear.

4 Feb 2021