Calcitriol is a form of Vitamin D3 with three alcohol groups. It increases gastrointestinal calcium absorption, stimulates osteoclastic calcium resorption from bone, facilitates the effect parathyroid hormone (PTH) has on bone resorption, and increases renal tubular absorption of calcium. Production of calcitriol by the cells of the proximal tubule of the nephron in the kidney is stimulated by hypocalcemia and hypophosphatemia as well as parathyroid hormone.
Researchers examined the relationship between vitamin D supplementation and osteoporosis-related fracture incidence.
Researchers investigated the correlation between vitamin D deficiency and metabolic syndrome (MetS) components.
Vitamin D's immunomodulatory and antiviral function.
Research investigates the impact of vitamin D supplementation on the incidence of major cardiovascular events in older adults. It examines whether monthly doses of vitamin D can alter the occurrence of heart-related problems.
Researchers screened various compounds for anti-viral properties against SARS-CoV-2.
Experts provide the first framework for treating a common and life-threatening metabolic complication of cancer known as hypercalcemia of malignancy in the Endocrine Society's new Clinical Practice Guideline.
According to recent estimates, over 140 million people from 50 countries regularly get exposed to arsenic through drinking water.
A new study examined published studies for a consistent association between vitamin D levels and coronavirus disease 2019 (COVID-19) severity.
A new study describes the nature and extent of the shift in dispensing these medications, as well as its eventual outcome.
In a new report published in The Lancet, a team of researchers discussed the possibility that vitamin D could offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The meta-analyses of randomized controlled trials performed from 2007 to 2020.
The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs).
A new paper published on the preprint server medRxiv* in May 2020 reports the first evidence that vitamin D deficiency and inadequate treatment could increase the chances of testing positive for COVID-19. This could shape the way for screening individuals at risk for vitamin D deficiency.
Excessive supplementation with vitamin D can cause bone loss and bone weakening, according to a new study.
What's good for our bones may also help stop cancer cells that develop resistance to multiple chemotherapy drugs.
Burosumab, a new injectable medicine to treat X-linked hypophosphatemia (XLH), an inherited form of rickets, demonstrates superior improvements in rickets and other outcomes compared with conventional therapy in an international, phase 3 clinical trial in children.
Researchers at Houston Methodist Research Institute and The University of Texas MD Anderson Cancer Center have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer.
The length of your telomeres appears to be a window into your heart health and longevity, and scientists are measuring them to see if vitamin D and omega-3 supplements really improve both.
Low levels of vitamin D in black teens correlates with low activity of a major mechanism for controlling gene expression that may increase their risk of cancer and other disease, researchers report.
Roswell Park Cancer Institute research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone.
In patients with chronic heart failure, the vitamin D metabolite 1,25-dihydroxyvitamin D (1,25(OH)2D), also called calcitriol, and its ratio to parathyroid hormone (PTH 1-84) may help predict cardiovascular death; and patients with decreased calcitriol and decreased ratio of calcitriol to PTH might benefit from more aggressive supplementation, a new study finds.