Cancer Immunotherapy News and Research

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University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

Researchers at the University of Louisville have received $5.8 million in two grants from the National Institutes of Health to expand their work to better understand and prevent immune system dysregulation responsible for acute respiratory distress, the condition responsible for serious illness and death in some COVID-19 patients.

2 Jun 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

UCF researcher develops a new, more precise treatment for acute respiratory viral infections

A University of Central Florida College of Medicine researcher has developed a new, more precise treatment for a major cause of illness around the world each year -; acute respiratory viral infections.

9 May 2023

Study pinpoints how gut microbes boost the body's response to cancer immunotherapy

Cancer immunotherapy has transformed the treatment of many types of cancer. Yet, for reasons that remain poorly understood, not all patients get the same benefit from these powerful therapies.

4 May 2023

New approach for efficient engineering of cell and gene therapies

A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods.

28 Apr 2023

Isolating tumor-reactive blood cells to treat cancers

Adoptive cell therapy (ACT) has become a promising immunotherapy tool to help treat advanced melanoma.

10 Apr 2023

Immunotherapy response in patients with advanced melanoma depends on prior treatments

Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.

10 Apr 2023

Regulatory T cell populations descend from two different origins, finds study

A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children's Hospital of Philadelphia (CHOP).

7 Apr 2023

How nanomedicine is revolutionizing care for cardiovascular disease

Researchers review recent advancements in nanomedicine treatment options for cardiovascular disease.

6 Apr 2023

Phase 2 study shows safety and efficacy of new drug in men with high-risk prostate cancers

A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

International panel develops standardized definitions of immunotherapy side effects

An international panel of oncology and immunotherapy experts led by RCSI's Professor Jarushka Naidoo, has developed standardized definitions of the side effects of cancer immunotherapy to assist clinicians in treating patients.

5 Apr 2023

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Researchers explored the correlation between autoimmunity and obesity.

3 Apr 2023

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20–30% patients with cancer respond to ICI treatment.

29 Mar 2023

Leaving lymph nodes intact until after immunotherapy could boost efficacy against solid tumors

Cancer treatment routinely involves taking out lymph nodes near the tumor in case they contain metastatic cancer cells.

20 Mar 2023

Novel immunotherapeutic strategies to target the complex tumor immune microenvironment in head and neck cancer

A symposium aiming to provide a better understanding of the tumor microenvironment, immune tolerogenic niches at cancer initiation, and novel immunotherapeutic strategies in head and neck cancer patients was featured at the 52nd Annual Meeting & Exhibition of the AADOCR, held in conjunction with the 47th Annual Meeting of the CADR.

20 Mar 2023

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Mar 2023

Study suggests a new way to develop intra-tumor immunotherapies to fight head and neck cancer

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a gene expressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.

13 Mar 2023

Components of the gut microbiome could be used to better predict efficacy of CAR-T cell therapy

Even though, according to recent preliminary studies, the risk of dying from cancer has declined within the European Union in recent years, cancers remain among the leading causes of death.

13 Mar 2023

Researchers explore potential new target for cancer immunotherapy

A new study posted to the bioRxiv* preprint server, focused on the role of YAP in regulating MHC-I APM expression within tumor cells.

27 Feb 2023

Cancer Immunotherapy News and Research

University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

Novel computational platform can expand the pool of cancer immunotherapy targets

UCF researcher develops a new, more precise treatment for acute respiratory viral infections

Study pinpoints how gut microbes boost the body's response to cancer immunotherapy

New approach for efficient engineering of cell and gene therapies

Isolating tumor-reactive blood cells to treat cancers

Immunotherapy response in patients with advanced melanoma depends on prior treatments

Regulatory T cell populations descend from two different origins, finds study

How nanomedicine is revolutionizing care for cardiovascular disease

Phase 2 study shows safety and efficacy of new drug in men with high-risk prostate cancers

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

International panel develops standardized definitions of immunotherapy side effects

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Leaving lymph nodes intact until after immunotherapy could boost efficacy against solid tumors

Novel immunotherapeutic strategies to target the complex tumor immune microenvironment in head and neck cancer

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

Study suggests a new way to develop intra-tumor immunotherapies to fight head and neck cancer

Components of the gut microbiome could be used to better predict efficacy of CAR-T cell therapy

Researchers explore potential new target for cancer immunotherapy

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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