Carcinoma News and Research

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Carcinoma is cancer that begins in the skin or in tissues that line or cover internal organs.

Targeting the Hedgehog pathway could be used in the treatment of neurodegenerative diseases

Aberrant activation of the Hedgehog (Hh) pathway has been associated with numerous malignancies including basal cell carcinoma, medulloblastoma, and pancreatic cancer. Several reports also suggest that positive regulators of the Hh pathway could be used in the treatment of neurodegenerative diseases.

27 Feb 2005

Protein called CK2 plays a deadly role in colorectal carcinoma

A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the body. This finding, by researchers at St. Jude Children's Research Hospital, is currently published in the online edition of Oncogene.

24 Feb 2005

Non-invasive and invasive breast cancers share the same genetic mutations

Women diagnosed with early stage, non–invasive breast cancer who carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer, may benefit from high risk treatment, Yale researchers report in the February 23 issue of Journal of the American Medical Association.

23 Feb 2005

2.5 million euros helps fight liver cancer

The overall project will concentrate on three areas where Europe is in a relatively favourable position compared with the US - human tissue resources, ribonucleic acid (RNA) technology, and structural proteomics. However, the initial focus will be on the development of genomics targets in hepatocellular carcinoma (HCC) or liver cancer as it is one of the leading causes of cancer death worldwide and has a very poor prognosis.

22 Feb 2005

Nonsurgical microspheres an option for liver cancer patients

A study in February’s Journal of Vascular and Interventional Radiology found that patients undergoing liver cancer treatment with Theraspheres?, radioactive microspheres containing Yittrium-90, can tolerate a 150 Gy single dose or 268 Gy repeated dose without risk of radiation-induced liver disease.

17 Feb 2005

Antigens produced by the Epstein Barr virus may provide an ideal target for cancer therapy

A typically innocuous virus found in 90 percent of people worldwide is the key to a new treatment for a cancer particularly common in North Africa and Southeast Asia.

16 Feb 2005

Coffee consumption may be associated with a decreased risk of hepatocellular carcinoma

Two new studies in the February 16 issue of the Journal of the National Cancer Institute examine the effects of coffee consumption on the incidence of liver and colorectal cancers. One study found that drinking coffee daily is associated with a decreased risk of liver cancer, while the other found no association between drinking coffee or tea and the risk of colorectal cancer.

15 Feb 2005

Avastin available across Europe within the next few weeks

Roche has announced that the European Commission has approved Avastin (bevacizumab, rhuMAb-VEGF), the new innovative anti-angiogenesis drug, for the treatment of patients with previously untreated metastatic colorectal cancer.

16 Jan 2005

Evaluation of BAY 43-9006 (Sorafenib) for pancreatic cancer

Oncologists from USC/Norris Comprehensive Cancer Center are running tests on a new pancreatic cancer drug that targets the cancer from two directions.

13 Jan 2005

Scientists identify genes that promote the growth and recurrence of skin cancer

Andrzej Dlugosz, M.D., a professor of dermatology in the U-M Medical School, and colleagues at the University of Michigan and the National Cancer Institute examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma – the most common form of cancer – and uncovered a subset of tumor cells that were resistant to inhibition of the Hedgehog pathway.

10 Jan 2005

Study shows women with invasive lobular carcinoma may not need chemotherapy before surgery

Women with a rare type of advanced breast cancer who do not benefit from primary (pre-surgical) chemotherapy still have been found to do better in the long run than patients with a more common advanced breast cancer who do respond to chemotherapy.

3 Jan 2005

Scientists have identified genes that promote the growth and recurrence of skin cancer

Dr. Andrzej Dlugosz and colleagues at the University of Michigan and the National Cancer Institute have examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma, the most common form of cancer, and have uncovered a subset of tumor cells that are resistant to inhibition of the Hh pathway.

28 Dec 2004

Relatives of lung cancer patients up to 3.5 times greater risk of developing lung cancer

First-degree relatives of lung cancer patients have a 2 to 3.5 times greater risk of developing lung cancer than the general population, and tobacco smoke plays a major role, even among those with a genetic predisposition, according to a study in the December 22/29 issue of JAMA.

22 Dec 2004

Major step forward in using saliva to detect oral cancer

Scientists funded by the National Institute of Dental and Craniofacial Research reported taking a major step forward in using saliva to detect oral cancer.

21 Dec 2004

Messenger RNA not only are measurable in saliva but can indicate a developing tumor

Scientists funded by the National Institute of Dental and Craniofacial Research reported today taking a major step forward in using saliva to detect oral cancer.

20 Dec 2004

New approach to genomic testing identifies women with low risk of breast cancer recurrence

An initial validation study presented by Exagen Diagnostics at the San Antonio Breast Cancer Symposium suggests it may soon be possible to distinguish good prognosis from poor prognosis in any newly diagnosed breast cancer patient based on DNA changes in the patient's tumor.

13 Dec 2004

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Using precise, radioactively labeled genetic probes, researchers at Jefferson Medical College have seen cancer gene activity from outside the body in laboratory mice. The probes, which work by attaching to genetic codes copied from an active cancer gene, may someday aid physicians and scientists in cancer detection and in determining the appropriate treatment for a cancer.

13 Dec 2004

Childhood cancer slowly increasing over the past 3 decades

Research from 19 European countries in this week’s issue of THE LANCET documents how childhood cancer, while still rare, has been slowly increasing over the past 3 decades.

13 Dec 2004

Breast MRI moderately useful for detecting breast cancer

In women with breast lesions that are suspicious for cancer, based on clinical examination or mammography, performing a breast MRI has high sensitivity but only moderate specificity for detecting breast cancer, but does not necessarily eliminate the need for tissue sampling, according to a study in the December 8 issue of JAMA.

8 Dec 2004

Revival of a unique and proven cancer treatment, neutron therapy

Northern Illinois University has announced plans to revive a unique and proven cancer treatment that blends advanced medical science with accelerator physics developed at Fermi National Accelerator Laboratory, a Department of Energy laboratory in Batavia, Ill.

7 Dec 2004

Carcinoma News and Research

Further Reading

Targeting the Hedgehog pathway could be used in the treatment of neurodegenerative diseases

Protein called CK2 plays a deadly role in colorectal carcinoma

Non-invasive and invasive breast cancers share the same genetic mutations

2.5 million euros helps fight liver cancer

Nonsurgical microspheres an option for liver cancer patients

Antigens produced by the Epstein Barr virus may provide an ideal target for cancer therapy

Coffee consumption may be associated with a decreased risk of hepatocellular carcinoma

Avastin available across Europe within the next few weeks

Evaluation of BAY 43-9006 (Sorafenib) for pancreatic cancer

Scientists identify genes that promote the growth and recurrence of skin cancer

Study shows women with invasive lobular carcinoma may not need chemotherapy before surgery

Scientists have identified genes that promote the growth and recurrence of skin cancer

Relatives of lung cancer patients up to 3.5 times greater risk of developing lung cancer

Major step forward in using saliva to detect oral cancer

Messenger RNA not only are measurable in saliva but can indicate a developing tumor

New approach to genomic testing identifies women with low risk of breast cancer recurrence

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Childhood cancer slowly increasing over the past 3 decades

Breast MRI moderately useful for detecting breast cancer

Revival of a unique and proven cancer treatment, neutron therapy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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