Cartilage News and Research

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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.

Lubricin research points to future therapies for osteoarthritis

New evidence to explain how the body's natural joint lubricant prevents the wear and tear that can lead to osteoarthritis has been uncovered by researchers at Duke University's Pratt School of Engineering.The findings may lead to new methods for treating arthritis, the researchers said.

11 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Inflammation, cartilage and bone erosions, joint destruction--that's the typical progression of arthritis and most rheumatic diseases.

4 Apr 2006

Sodium hyaluronate shown to help chronic shoulder pain

After the rise in safety concerns surrounding Vioxx and other Cox-2 inhibitors, people suffering from chronic shoulder pain were left with just two therapy options at opposite extremes - take Advil, or have surgery.

28 Mar 2006

Stem cells, gene therapy and allograft applications show promise for treating orthopaedic conditions

Recent advances in gene therapy, stem cells and other promising applications are offering new hope for patients and helping orthopaedic surgeons provide state-of-the-art treatment for various frame-related conditions.

23 Mar 2006

Scientists create new type of 'bio-gel'

Scientists at The University of Manchester have created a new type of 'bio-gel' which provides a pH neutral environment for culturing cells in 3D, as published in the journal Advanced Materials.

From The University of Manchester 7 Mar 2006

Scientists reprogramme malignant melanoma cells to become normal pigment cells

Scientists at Northwestern University and the Stowers Institute for Medical Research have reprogrammed malignant melanoma cells to become normal melanocytes, or pigment cells, a development that may hold promise in treating of one of the deadliest forms of cancer.

1 Mar 2006

Study associates meniscal damage with advanced cartilage loss in early osteoarthritis

Cartilage loss is a major component of osteoarthritis (OA), a joint disease that affects over 20 million Americans. In knee OA, cartilage loss is influenced by knee injury, as well as obesity and age. Every healthy knee is supported and protected by a pair of meniscus.

27 Feb 2006

Efficacy of glucosamine, chondroitin sulfate may depend on level of osteoarthritis pain

The popular dietary supplements glucosamine and chondroitin sulfate proved no better than a placebo in relieving osteoarthritis knee pain in most participants of a major national trial.

23 Feb 2006

Glucosamine/Chondroitin combo helps those with moderate to severe joint pain

According to a new study by the National Institutes of Health, people with moderate to severe joint discomfort found that a combination of glucosamine and chondroitin resulted in significant pain and function improvement.

23 Feb 2006

Radiologists more accurately identify damage to knee cartilage by using four radiologic 'signs'

Using the four signs to identify the extent and type of damage to knee cartilage makes interpreting MRIs with higher degrees of accuracy easier for any radiologist, regardless of their level of expertise.

21 Feb 2006

Innovative approach to cartilage repair

Leeds bioengineers have developed an innovative technique for cartilage repair combining the self-healing powers of the body with stem cell science to help young people avoid debilitating knee problems and give hope to arthritis sufferers.

2 Feb 2006

Deer antlers provide important clues for stem cell research

Research carried out by veterinary scientists at the Royal Veterinary College reveals that deer antler regeneration may use stem cells and involves similar mechanisms to those used in limb development.

2 Feb 2006

First-of-its-kind study in heart attack patients seeks to prevent heart failure with stem cells

University of Rochester Medical Center researchers have announced the launch of a study that will examine whether transplanted stem cells can be safely used to treat damaged heart muscle in patients just after their first heart attack.

23 Jan 2006

Evidence supports combination therapy for achieving remission of early rheumatoid arthritis

A chronic and potentially crippling inflammatory disorder, rheumatoid arthritis (RA) progressively wears away the cartilage and bone.

8 Jan 2006

Gene discovery may prevent craniofacial birth defects

Craniofacial researchers have developed an animal model that explains how skull malformations occur and how they might be prevented.

22 Dec 2005

Light at the end of the tunnel for arthritis sufferers

There is at last a light at the end of the tunnel for Arthritis sufferers.

21 Dec 2005

Hydrogels to potentially make chemotherapy and tissue regeneration more convenient and safe

Scientists at the Institute of Bioengineering and Nanotechnology (IBN) have invented an injectable and biodegradable gel that can deliver drugs at targeted sites or act as a scaffold for tissue repair.

15 Dec 2005

$Bone quality regulator identified - possible target for preventing and treating bone fractures$

Bone quality regulator identified - possible target for preventing and treating bone fractures

University of California - San Francisco (UCSF) scientists have determined that the quality of bone matrix, a key component of bone, is regulated by a molecule known as transforming growth factor beta.

13 Dec 2005

New insights into pain mechanisms

Long treated as a side effect, pain is now widely recognized as an integral part of patient care.

7 Dec 2005