Cartilage News and Research

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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.

Novel method boosts MSC efficacy for articular cartilage repair

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, alongside collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP), have developed a novel method to enhance the ability of mesenchymal stromal cells (MSCs) to generate cartilage tissue by adding ascorbic acid (AA) during MSC expansion.

18 Oct 2024

NIH funding supports investigation of skeletal stem cells in craniofacial bone disorders

Researchers at UTHealth Houston have been awarded an $8.1 million grant by the National Institutes of Health (NIH) to examine skeletal stem cells as potential drivers of craniofacial bone diseases and deformities.

10 Oct 2024

Study reveals osteochondritis risk in children undergoing knee surgery

Growing pains are common in maturing children, but sometimes this growth can be irregular and cause injury. Discoid lateral meniscus (DLM), a misshapen knee cartilage, is one such occurrence that can degenerate into osteochondritis dissecans, a joint disorder where the bone and joint begin to separate from the rest of the bones.

8 Oct 2024

Overcoming CRISPR's side effects for therapeutic applications

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism. It's a reagent-;a substance that facilitates a reaction-;that combines an enzyme with a programmable RNA capable of locating specific genetic sequences. Once guided to the correct spot, the enzyme acts like a pair of scissors, cutting, replacing, or deleting sequences of DNA.

7 Oct 2024

Study highlights potential for targeting macrophages to improve rheumatoid arthritis outcomes

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health system of ~€544 million.

27 Sep 2024

Age-related fibroblast changes in males drive aggressive melanoma

Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.

6 Sep 2024

The impact of microgravity on cancer development and treatment

The Wake Forest Institute for Regenerative Medicine (WFIRM) is honored to announce its selection for a pioneering cancer research project that will take place aboard the International Space Station (ISS). The project, one of only five chosen through a competitive solicitation by the ISS National Lab in partnership with NASA, aims to explore the effects of microgravity on cancer development and treatment.

6 Sep 2024

Wake Forest Institute for Regenerative Medicine joins new NSF-funded pandemic prediction initiative

The Wake Forest Institute for Regenerative Medicine is proud to be part of a new initiative, supported by an $18 million grant from the U.S. National Science Foundation (NSF), aimed at enhancing global pandemic prediction and prevention capabilities.

23 Aug 2024

Study finds potential for antidiabetic drugs to modify osteoarthritis risk

Whether antidiabetic medications could potentially be used as disease-modifying osteoarthritis drugs or DMOADs for the therapeutic management of osteoarthritis.

21 Aug 2024

New bioactive material regenerates high-quality cartilage in the knee joints of large-animal model

Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model.

5 Aug 2024

Olympic athletes overcome health challenges to reach the pinnacle of their sport

The athletes have done the training and achieved their dreams, a trip to the Paris Olympics set to begin Friday July 26th.

2 Aug 2024

Breakthrough therapy heals spinal cord injuries

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries.

27 Jul 2024

Cord blood banking industry faces scrutiny over unproven claims and high costs

Some private UK biobanks may be misleading expectant parents about the value of storing umbilical cord blood to treat life-threatening diseases that may arise in their child in the future, reveals an investigation by The BMJ, published today.

25 Jul 2024

Kneecap shape could indicate a person's risk of developing osteoarthritis

The shape of a person's kneecap could be an indicator of whether they're more at risk of developing osteoarthritis, according to a new study from The Australian National University (ANU).

23 Jul 2024

Scientists solve long-standing puzzle about how breastfeeding women's bones remain strong

Researchers at UCSF and UC Davis solved a long-standing puzzle on how the bones of breastfeeding women stay strong even as they lose calcium to milk.

11 Jul 2024

Osteoarthritis linked to accelerated progression of severe long-term conditions

Osteoarthritis-;a condition in which the protective cartilage on the ends of bones breaks down-;may more than double the risk of speedy progression to accumulating severe long term conditions (multimorbidity), finds a 20 year study published in the open access journal RMD Open.

9 Jul 2024

High-impact exercise boosts bone density without harming knee health in postmenopausal women

Study demonstrates that six months of high-impact unilateral exercise significantly improves femoral neck bone density in postmenopausal women without negatively affecting knee osteoarthritis progression.

2 Jul 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

Unveiling the heterogeneity of skeletal stem cells across skeletal regions and developmental stages

SSCs are essential for bone development, homeostasis, and repair. Recent studies have identified distinct SSC populations in long bones, craniofacial bones, and spine.

5 Jun 2024

Space experiment offers new path to fighting osteoarthritis

More than 650 million people worldwide are affected by osteoarthritis, and few treatment options exist. However, new promising results from an International Space Station (ISS) National Laboratory-sponsored experiment detail a tissue chip model that accurately reproduces the conditions under which post-traumatic osteoarthritis (PTOA) is initiated. Published in Frontiers in Space in March, these findings mark an important step forward in understanding and testing treatments for the underlying causes of osteoarthritis and related conditions.

3 Jun 2024