Cell Death News and Research

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The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Researchers summarize available data on pyroptosis in the context of renal fibrosis, as well as its prevention and treatment.

1 Aug 2023

Two new subtypes of HPV+ head and neck cancers identified

Cases of human papillomavirus (HPV)-associated cancers of the head and neck, known as head and neck squamous cell carcinoma (HNSCC), are rapidly increasing throughout the United States.

31 Jul 2023

Newly identified protein plays a key role in the action of emerging anticancer therapies

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

31 Jul 2023

Two new compounds can block cancer cell’s escape route

Cancer cells are capable of escaping chemotherapy and radiotherapy by activating a signaling pathway that prevents them from dying.

27 Jul 2023

New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Scientists unravel step-by-step activation process of protein with deep evolutionary history

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a biotechnology tool.

26 Jul 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

Brazilian researchers identify new way to stop excessive inflammation in COVID-19

Researchers at the University of São Paulo (USP) in Brazil have identified a new class of molecules capable of stopping the excessive inflammation typical of the severe form of COVID-19 without impairing the immune response to SARS-CoV-2, the virus that causes the disease.

25 Jul 2023

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Cutting-edge research at the Luxembourg Institute of Health reveals the ground-breaking therapeutic potential of the compound FL3 in inhibiting oncogene translation and rewiring cancer cell metabolism, opening up new therapeutic opportunities for leukemia patients.

24 Jul 2023

Study provides new insights into how SARS-CoV-2 affects glucose metabolism

Research conducted at the University of São Paulo (USP) in Brazil shows that SARS-CoV-2, the virus that causes COVID-19, can infect liver cells (hepatocytes), stimulating glucose production and leading to a condition similar to diabetes (hyperglycemia) in hospitalized patients, even if their blood sugar level was normal before they were admitted to hospital.

19 Jul 2023

New protein discovered in Alzheimer's brains could lead to better diagnosis and treatment

Alzheimer's is considered a disease of old age, with most people being diagnosed after 65. But the condition actually begins developing out of sight many years before any symptoms emerge.

19 Jul 2023

Study shows how NSAIDs exacerbate C. difficile infections

Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide?

19 Jul 2023

The role of airway epithelium: insights into asthma and COPD pathogenesis

Study discussed how injury and abnormal repair of the airway epithelium drive chronic obstructive pulmonary disease (COPD) and asthma.

17 Jul 2023

Scientists discover mechanism of cell death in people living with HIV

Professor Simona Stäger's team has made a breakthrough in the study of the human immunodeficiency virus (HIV).

13 Jul 2023

Mitochondrial impairment, not inflammation, may be main driver of Gulf War Illness symptoms

Gulf War Illness (GWI) is a chronic multisymptom health condition affecting one-third of all veterans who served in the 1991 Gulf War, most of whom remain afflicted more than 30 years later.

12 Jul 2023

AI tool can rapidly decode brain tumor DNA during surgery

Scientists have designed an AI tool that can rapidly decode a brain tumor's DNA to determine its molecular identity during surgery -; critical information that under the current approach can take a few days and up to a few weeks.

7 Jul 2023

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Researchers present the mechanisms by which SARS-CoV-2 could infect the brain and affect memory.

5 Jul 2023

Novel engineered approach makes protein aggregates amenable to spatial manipulations in cells

Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease.

30 Jun 2023

Novel anti-cancer drug found to sensitize tumor cells to ferroptosis

A team of researchers led by Dr. Marcus Conrad from Helmholtz Munich discovered a novel anti-cancer drug, called icFSP1, which sensitizes cancer cells to ferroptosis.

28 Jun 2023

Pyroptosis: A potential therapeutic target for lung cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

28 Jun 2023

Cell Death News and Research

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Two new subtypes of HPV+ head and neck cancers identified

Newly identified protein plays a key role in the action of emerging anticancer therapies

Two new compounds can block cancer cell’s escape route

New gene editing approach could revolutionize the treatment of blood disorders

Scientists unravel step-by-step activation process of protein with deep evolutionary history

Tumor-derived GDF-15 suppresses immunotherapy response

Brazilian researchers identify new way to stop excessive inflammation in COVID-19

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Study provides new insights into how SARS-CoV-2 affects glucose metabolism

New protein discovered in Alzheimer's brains could lead to better diagnosis and treatment

Study shows how NSAIDs exacerbate C. difficile infections

The role of airway epithelium: insights into asthma and COPD pathogenesis

Scientists discover mechanism of cell death in people living with HIV

Mitochondrial impairment, not inflammation, may be main driver of Gulf War Illness symptoms

AI tool can rapidly decode brain tumor DNA during surgery

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Novel engineered approach makes protein aggregates amenable to spatial manipulations in cells

Novel anti-cancer drug found to sensitize tumor cells to ferroptosis

Pyroptosis: A potential therapeutic target for lung cancer

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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