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Tunneling nanotubes can assist SARS-CoV-2 propagation

A new study found that tunneling nanotubes (TNTs) offer a pathway for SARS-CoV-2 neuronal spreading.

26 Jul 2022

Researchers discover a ‘weak spot’ that makes multi-drug resistant tumors vulnerable

One of the greatest challenges facing cancer researchers is to understand why some patients don't respond to treatments.

22 Jul 2022

New biomimetic formulation developed to tackle glioblastoma multiforme

Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few treatment options. New and effective approaches for GBM treatment are therefore urgently needed.

22 Jul 2022

Study may help overcome some obstacles to the development of nanoparticle-based drugs

Using nanoparticles to deliver cancer drugs offers a way to hit tumors with large doses of drugs while avoiding the harmful side effects that often come with chemotherapy.

21 Jul 2022

Scientists introduce SARS-CoV-2 phenotype screening for identifying novel antiviral drugs

Researchers introduced a phenotypic screening assay for identifying compounds with SARS-CoV-2 inhibition potential based on caspase 3/7 activation.

20 Jul 2022

The interaction between SARS-CoV-2 and influenza A during coinfection

Researchers assessed the host response to influenza A and COVID-19 during coinfection.

14 Jul 2022

Bioactive compounds in a marine sponge show potential to kill antibiotic-resistant bacteria

A research group led by scientists at the University of São Paulo (USP) in São Carlos, Brazil, has identified a number of bioactive compounds in a marine sponge collected on Fernando de Noronha, an archipelago about 400 km off the coast of Brazil's Northeast region.

13 Jul 2022

The impact of gene amplification in virus adaptation through intermediate hosts

Researchers assessed the impact of gene amplification on cross-species adaptation.

12 Jul 2022

SARS-CoV-2 Omicron BA.5 tropism shifting back to ancestral strains

In a recent study posted to the medRxiv* pre-print server, researchers from Australia and Switzerland gathered data to help track and manage ongoing and future infection waves by new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Omicron globally.

12 Jul 2022

Moffitt researchers discover kidney cancer-specific splicing variant biomarkers

Kidney cancer accounts for only 4% of all cancers in the United States; however, its incidence has more than doubled since 1975, with the most common type being clear cell renal cell carcinoma.

8 Jul 2022

Study suggests spironolactone may improve clinical outcomes in COVID-19

Researchers performed an integrative analysis of clinical outcomes and viral entry networks in severe COVID-19 infection.

8 Jul 2022

Study opens up a new avenue for the development of selective drug therapies

Researchers at the Department of Energy's Oak Ridge National Laboratory have definitively linked the function of a specific domain of proteins important in plant-microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.

5 Jul 2022

SARS-CoV-2 virus undertakes a massive takeover of the body's fat-processing system

The virus that causes COVID-19 undertakes a massive takeover of the body's fat-processing system, creating cellular storehouses of fat that empower the virus to hijack the body's molecular machinery and cause disease.

28 Jun 2022

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

A recent study posted to the bioRxiv* preprint server assessed whether niclosamide could be employed in coronavirus disease 2019 (COVID-19) therapy.

28 Jun 2022

Antigenic differences between early SARS-CoV-2 variants

Researchers used antigenic cartography to quantify and visualize antigenic differences between multiple SARS‐CoV‐2 variants.

27 Jun 2022

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Scientists have described the development of a modified A549 cell line that shows a robust expression of ACE2 and TMPRSS2 and high susceptibility to SARS-CoV-2 infection.

24 Jun 2022

Mutation in SARS-CoV-2 nucleocapsid protein found to enhance replication and pathogenicity

Researchers investigated a highly variable region at residues 203 to 205 in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein.

23 Jun 2022

New combination of drugs effective against T-cell acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed.

20 Jun 2022

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Researchers assessed the role of adenoside diphosphate (ADP)-ribosylation factor 6 (ARF6) in SARS-CoV-2 infection.

14 Jun 2022

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States demonstrated that the acidic milieu of the nasal cavity is critical for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism.

14 Jun 2022