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Impaired energy production in heart muscle may underlie heart failure in some hypertensive patients

Many people with long-standing high blood pressure develop heart failure.

12 Aug 2007

Chromatin remodeling complex connected to DNA damage control

When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.

12 Aug 2007

Leptin controls our fondness for food

Scientists have discovered that leptin, one of the key hormones responsible for reducing hunger and increasing the feeling of fullness, also controls our fondness for food.

12 Aug 2007

New pathway for inflammation-induced cancer

A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells, researchers at The University of Texas M. D. Anderson Cancer Center report in the August edition of the journal Cell .

11 Aug 2007

Mechanistic model of DNA repair

Ionizing radiation, toxic chemicals, and other agents continually damage the body's DNA, threatening life and health: unrepaired DNA can lead to mutations, which in turn can lead to diseases like cancer.

6 Aug 2007

Neck muscles could play a crucial role in controlling blood pressure, heart rate and breathing

A chance discovery in the lab has helped University of Leeds scientists to show how the treatment for a stiff neck could do wonders for your blood pressure.

3 Aug 2007

Discredited Korean embryonic stem cells' true origins revealed

A report from researchers at Children's Hospital Boston and the Harvard Stem Cell Institute sheds new light on a now-discredited Korean embryonic stem cell line, setting the historical record straight and also establishing a much-needed set of standards for characterizing human embryonic stem cells.

3 Aug 2007

Fear protein found

A University of Iowa study shows that loss or chemical inhibition of a protein, known as acid sensing ion channel protein (ASIC1a), reduces innate fear behavior in lab animals, making normally timid mice relatively fearless.

2 Aug 2007

Drugs designed to disable enzyme TOPK could have anti-cancer benefits

Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death.

1 Aug 2007

Directed nanoparticles deliver gene therapy

After binding DNA segments to tiny iron-containing spheres called nanoparticles, researchers have used magnetic fields to direct the nanoparticles into arterial muscle cells, where the DNA could have a therapeutic effect.

31 Jul 2007

Prenatal alcohol exposure alters brain activity in the frontal-striatal areas

Heavy prenatal alcohol exposure does not always lead to fetal alcohol syndrome (FAS); sometimes it can lead to cognitive and behavioral deficits in the absence of craniofacial features needed to make an FAS diagnosis.

25 Jul 2007

Discovery of new brain mechanism involved with waking up

How do we wake up? How do we shift from restful sleep to dreaming? Researchers at the University of Arkansas for Medical Sciences (UAMS) have discovered a new brain mechanism that just might explain how we do that.

20 Jul 2007

New study explains placebo effect

Why do some people experience a “placebo effect” that makes them feel better when they receive a sham treatment they believe to be real — while other people don't respond at all to the same thing, or even feel worse?

19 Jul 2007

Researchers pinpoint brain region linked to placebo effect

Researchers have pinpointed a brain region central to the machinery of the placebo effect, the often controversial phenomenon in which a person's belief in the efficacy of a treatment such as a painkilling drug influences its effect.

19 Jul 2007

Role prefrontal cortex plays in memory

A research with experimental rats carried out by the Institute of Neuroscience of the UAB describes the brain region connected to how our declarative memory functions.

18 Jul 2007

Insights into side effects of HIV protease inhibitors

UCLA scientists, along with collaborators from Purdue University, have demonstrated that HIV protease inhibitors, crucial drugs for HIV treatment block a cellular enzyme important for generating the structural scaffolding for the cell nucleus.

17 Jul 2007

Protein km23 - potential target for ovarian cancer treatment

A traffic cop protein in the cell may have an even more important role: transporting a messenger protein that tells components in the nucleus to stop cell growth.

17 Jul 2007

Chromosome glue repairs damaged DNA

When a strand of DNA breaks in the body's cells, it normally does not take long until it has been repaired.

16 Jul 2007

Chemical in brain acts like a fuel gauge

The concept that a drop in blood sugar triggers a craving for food is best understood just before lunchtime. But exactly how the process unfolds has proven difficult to explain, even on a full stomach.

9 Jul 2007

Artificially replicating the male genome may help infertile men

Artificially replicating the male genome could help men with very low sperm counts become fathers, a scientist told the 23rd annual conference of the European Society of Human Reproduction and Embryology.

4 Jul 2007