Cell Nucleus News and Research

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Scientist develops way to deliver promising genetic tool into living cells

By exploiting an HIV protein that readily traverses cell membranes, Carnegie Mellon University scientists have developed a new way to introduce a gene-like molecule called a peptide nucleic acid (PNA) directly into live mammalian cells, including human embryonic stem (ES) cells.

6 Dec 2004

Episome vectors offer fresh angle to gene therapy

A European research team is seeking to overcome the early setbacks suffered by the promising new field of ‘gene therapy’ by developing a revolutionary delivery technique, known as ‘episome vectors’. This breakthrough could pave the way to treating hereditary diseases by injecting the body with healthy versions of damaged genes.

6 Dec 2004

Smoking habits during pregnancy may cause genetic instability in the foetus

The Spanish Pediatrics Association has recently awarded the Pediatrics laboratory at the University of Navarre for a research into tobacco and foetal genetic instability.

2 Dec 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

Discovery of gene mutation in fruit flies that alters sensitivity to crack cocaine

Researchers at the University of California, San Francisco (UCSF) and New York University have discovered a gene mutation in fruit flies that alters sensitivity to crack cocaine and also regulates their internal body clock.

23 Nov 2004

Fluorescent protein tool may speed identification of molecular changes that reveal cells' inner workings

Scientists at Johns Hopkins and the University of Texas Medical Branch have created a new tool that easily reveals when and where a key cellular signal is active.

16 Nov 2004

The brain's dopamine system is key to alcoholism

Among the many genes that may contribute to an individual's susceptibility to alcoholism, those in the dopamine system are of special interest because addictive substances can activate this system.

14 Nov 2004

Discovery of internal molecular clock that governs the metabolism of sugars and fats within the body

Researchers at the University of Pennsylvania School of Medicine have discovered that components of the internal molecular clock of mammals have an important role in governing the metabolism of sugars and fats within the body.

4 Nov 2004

An errant enzyme linked to bipolar disorder impairs awareness, perception and reasoning

The disturbed thinking, impaired judgment, impulsivity, and distractibility seen in mania, a destructive phase of bipolar disorder, may be traceable to overactivity of protein kinase C (PKC), suggests the study, funded by the National Institute of Mental Health (NIMH) and National Institute on Aging (NIA), and the Stanley Foundation.

1 Nov 2004

Cellular enzyme represents a potential new target for developing improved HIV drugs

Scientists have discovered that a cellular enzyme helps ferry HIV genetic instructions out of the cell nucleus where they can then be translated into proteins to begin their most destructive work.

1 Nov 2004

New role for a key protein involved in muscle contraction

Overturning a scientific stereotype, researchers at the University of Illinois at Chicago have discovered a new role for a key protein involved in muscle contraction and shown it is present not just in the cytoplasm of cells but in the nucleus as well.

1 Nov 2004

Interaction of nervous system proteins help researchers better understand age-related memory and hearing loss

In a finding that may one day help researchers better understand age-related memory and hearing loss, scientists have shown that two key nervous system proteins interact in a manner that helps regulate the transmission of signals in the nervous system.

29 Oct 2004

Smoking shown to quell painful sensations and heighten positive emotions

Smokers often say that lighting up a cigarette can calm their nerves, satisfy their craving and help them relax.

28 Oct 2004

Lighting up the human brain at night

Most people are aware that light affects human behaviour and can be used to treat disorders such as Seasonal Affective Disorder, but now researchers from the University of Surrey and the University of Liege have found new evidence that light administered during the night immediately reduces sleepiness and boosts human brain function.

25 Oct 2004

A single change in a person’s DNA can contribute to a range of life-shortening risk factors

A woman with hypertension, low magnesium levels, and a cooperative family allowed scientists to pinpoint the mutation, which affects the genes of the mitochondria — the energy-producing power plants of the cell that are passed from mother to offspring.

25 Oct 2004

Deep brain stimulation could help alleviate Parkinson’s symptoms on both sides of the body

For many patients with advanced Parkinson’s disease, deep brain stimulation can mean the difference between having difficulty walking and being able to run.

22 Oct 2004

Researchers are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes

Researchers at UT Southwestern Medical Center at Dallas are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes.

19 Oct 2004

Research shows brain cells move like a two-stroke engine

Following the often-quoted advice of Yogi Berra — "You can observe a lot by just watching" — Rockefeller University scientists show that nerve cells in the developing brains of humans and other mammals move in a two-part "step" led by a structure within the cell called the centrosome.

13 Oct 2004

First use of technology called ubiquitin-mediated fluorescence complementation to study a cell-signaling mechanism called ubiquitination

Researchers at the University of Michigan Medical School and Howard Hughes Medical Institute have found a way to see proteins in cells that have been tagged by a molecular “sticky note” called ubiquitin.

8 Oct 2004

Discovery of key molecular step which allows cancer cells to move to different parts of the body

Researchers at The University of Texas M. D. Anderson Cancer Center have figured out a key molecular step by which a cancer cell can unhook itself from the mesh weave of other cancer cells in a tumor, and move away to a different part of the body - the process, known as metastasis, that makes cancer so dangerous.

27 Sep 2004

Cell Nucleus News and Research

Scientist develops way to deliver promising genetic tool into living cells

Episome vectors offer fresh angle to gene therapy

Smoking habits during pregnancy may cause genetic instability in the foetus

New research may lead to treatments for atherosclerosis

Discovery of gene mutation in fruit flies that alters sensitivity to crack cocaine

Fluorescent protein tool may speed identification of molecular changes that reveal cells' inner workings

The brain's dopamine system is key to alcoholism

Discovery of internal molecular clock that governs the metabolism of sugars and fats within the body

An errant enzyme linked to bipolar disorder impairs awareness, perception and reasoning

Cellular enzyme represents a potential new target for developing improved HIV drugs

New role for a key protein involved in muscle contraction

Interaction of nervous system proteins help researchers better understand age-related memory and hearing loss

Smoking shown to quell painful sensations and heighten positive emotions

Lighting up the human brain at night

A single change in a person’s DNA can contribute to a range of life-shortening risk factors

Deep brain stimulation could help alleviate Parkinson’s symptoms on both sides of the body

Researchers are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes

Research shows brain cells move like a two-stroke engine

First use of technology called ubiquitin-mediated fluorescence complementation to study a cell-signaling mechanism called ubiquitination

Discovery of key molecular step which allows cancer cells to move to different parts of the body

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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