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Study sheds light on the mechanisms behind circadian rhythms

New research from a multidisciplinary team helps to illuminate the mechanisms behind circadian rhythms, offering new hope for dealing with jet lag, insomnia and other sleep disorders.

26 Apr 2023

Discovery enables a clear diagnosis for more patients with androgen insensitivity syndrome

Steroid hormones, to which belong sex hormones like estrogen or testosterone, are important signaling molecules and are responsible among other things for controlling female and male phenotypic sex differentiation.

27 Mar 2023

UVA researchers discover a key trigger for non-alcoholic fatty liver disease

University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.

9 Feb 2023

Study solves a 50-year mystery about messenger RNAs

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine.

1 Feb 2023

Researchers discover a protein that makes melanoma more aggressive

Research led by Queen Mary University of London, King's College London and the Francis Crick Institute has identified a protein that makes melanoma, the most serious type of skin cancer, more aggressive by giving cancer cells the ability to change the shape of their nucleus – a characteristic which allows the cells to migrate and spread around the body.

9 Jan 2023

New insights on the circadian clock of Drosophila melanogaster

The higher the temperatures, the faster physiological processes are. But there is an exception: the so-called circadian clock, which regulates the sleep-wake cycle in organisms.

30 Dec 2022

Study explores cellular alterations in six distinct neurodegenerative diseases

A perplexing range of neurodegenerative diseases are known to attack distinct regions of the brain, causing severe cognitive and motor deficit.

21 Dec 2022

New insights into biophysical origins of the genome's organization inside the cell nucleus

A team of scientists has uncovered the physical principles-;a series of forces and hydrodynamic flows-;that help ensure the proper functioning of life's blueprint.

19 Dec 2022

Extraordinary plasticity of the glucocorticoid receptor revealed

Glucocorticoids —such as cortisone— are among the most widely used anti-inflammatory drugs, and are used to treat asthma, psoriasis, organ transplantation and even COVID-19.

15 Dec 2022

Signaling pathway within brain cells regulates sleep

A good night's sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply?

12 Dec 2022

MYC proteins form hollow spheres that shield the genome of cancer cells

MYC genes and their proteins play a central role in the emergence and development of almost all cancers. They drive the uncontrolled growth and altered metabolism of tumour cells. And they help tumours hide from the immune system.

23 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Minimally invasive reporter system allows highly sensitive monitoring of RNA production

The better we understand cellular processes such as RNA regulation, the better molecular therapies can be developed.

15 Nov 2022

CLIMB method offers a more efficient way to uncover biologically meaningful changes in genomic data

A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions -; such as cell types or tissues.

14 Nov 2022

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

In a new study, researchers reported severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein and S messenger ribonucleic acid (mRNA) nuclear co-translocation as a novel feature of SARS-CoV-2 pathogenesis.

30 Sep 2022

MIT researchers use new technique to gather insight into repetitive protein sequences

About 70 percent of all human proteins include at least one sequence consisting of a single amino acid repeated many times, with a few other amino acids sprinkled in. These "low-complexity regions" are also found in most other organisms.

13 Sep 2022

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food".

9 Sep 2022

Pitt researchers describe a pathway by which cells repair damaged lysosomes

Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash.

8 Sep 2022

Study reveals a vital route through which fascin promotes cancer development

The study reveals an important route through which fascin promotes cancer development and provides insights into potential pathways that could block its action.

30 Aug 2022

Study reveals a 'stealing' mechanism that contributes to antibody diversity

A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery.

29 Aug 2022