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Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia. Despite advances in treatments, patients have an extremely poor prognosis, highlighting the need to explore the genetic components that lead to the formation of T-ALL, as well as the need to discover new targeted therapeutic approaches and treatment resistance.

14 Dec 2021

Flawed genetic switches could be at the origin of malformations or developmental diseases

Embryonic development follows delicate stages: for everything to go well, many genes must coordinate their activity according to a very meticulous scheme and tempo. This precision mechanism sometimes fails, leading to more or less disabling malformations.

14 Dec 2021

New therapeutic approach prevents growth of metastatic tumors by putting cancer cells to sleep

A new therapeutic approach prevents the growth of metastatic tumors in mice by forcing cancer cells into a dormant state in which they are unable to proliferate.

23 Nov 2021

Viral biomolecular condensation

A review published in PLOS Pathogens deconstructs virus condensation and provides a biochemical background for LLPS.

19 Nov 2021

Scientists develop a single-cell chromatin atlas for the human genome

Researchers at University of California San Diego have produced a single-cell chromatin atlas for the human genome.

14 Nov 2021

Protein plays a previously unknown role in halting cell cycle in response to stressful conditions

UT Southwestern researchers have identified a new mechanism by which stress causes cells to stop dividing.

27 Oct 2021

Novel pathways to target breast cancer identified

A pathway helping the breast cancer protein BRCA1 repair damaged DNA has been identified by University of Queensland researchers in a study that will inform future targeted therapies.

20 Oct 2021

New algorithm provides a high-definition analysis of genome organization in single cells

Within the microscopic boundaries of a single human cell, the intricate folds and arrangements of protein and DNA bundles dictate a person's fate: which genes are expressed, which are suppressed, and -; importantly -; whether they stay healthy or develop disease.

11 Oct 2021

Study illuminates how BRD4 protein directs the spatial organization of DNA within cell nucleus

New research is advancing understanding of certain cancers and complex congenital disorders by illuminating how BRD4, a protein that scientists have studied for years, directs the spatial organization of DNA within the nucleus of the cell, a function critical for stem cell differentiation into muscle cells.

7 Oct 2021

Damaging DNA builds up in the eyes to drive blinding age-related macular degeneration

Damaging DNA builds up in the eyes of patients with geographic atrophy, an untreatable, poorly understood form of age-related macular degeneration that causes blindness, new research from the University of Virginia School of Medicine reveals.

1 Oct 2021

Study provides novel insights into how KLF4 influences gene expression

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression.

23 Sep 2021

Research project focusing on membraneless organelles receives funding from Volkswagen Foundation

As part of its "Life?" project, the Volkswagen Foundation is funding a research project that is placing membraneless organelles within cells in the spotlight as a way of understanding the fundamental processes that are essential to life.

6 Sep 2021

Researchers decipher genetic mechanisms governing the speed of protein synthesis

In all eukaryotic organisms, genetic material is stored in the cell nucleus in the form of DNA. In order to be used, this DNA is first transcribed into messenger RNA in the cell cytoplasm, then translated into protein with the help of ribosomes, small machines capable of decoding messenger RNA to synthesise the appropriate proteins.

31 Aug 2021

Cell Nucleus News and Research

Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

Flawed genetic switches could be at the origin of malformations or developmental diseases

New therapeutic approach prevents growth of metastatic tumors by putting cancer cells to sleep

Viral biomolecular condensation

Scientists develop a single-cell chromatin atlas for the human genome

Protein plays a previously unknown role in halting cell cycle in response to stressful conditions

Novel pathways to target breast cancer identified

New algorithm provides a high-definition analysis of genome organization in single cells

Study illuminates how BRD4 protein directs the spatial organization of DNA within cell nucleus

Damaging DNA builds up in the eyes to drive blinding age-related macular degeneration

Study provides novel insights into how KLF4 influences gene expression

Research project focusing on membraneless organelles receives funding from Volkswagen Foundation

Researchers decipher genetic mechanisms governing the speed of protein synthesis

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

New mouse line reveals the state of protein balance in the mammalian brain for the first time

A multi-scale cryo-correlative platform to image SARS-CoV-2 in Vero cells

Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

SMC protein complex plays a decisive role in the dynamics of holocentromeres

Protein involved in cell migration offers clues to cancer metastases

Researchers gain new insights into the pathology of Usher syndrome

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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