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German scientists synthesize new compound that reduces stroke damage

A group of German scientists has synthesized a new compound that dramatically decreases the damage to neurons in rats demonstrating stroke symptoms.

16 May 2006

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.

16 Apr 2006

Lack of response to herceptin may be reversed with PI3K inhibiting agents

Breast cancer patients with HER2-positive tumors who don't respond to Herceptin (trastuzumab) may benefit from cocktail therapy that includes Herceptin along with one or more PI3K inhibiting agents, say researchers at the University of Texas M. D. Anderson Cancer Center.

11 Apr 2006

More than a billion may suffer from vitamin D deficiency

More than a billion may suffer from vitamin D deficiency. Consequences may be more severe than thought. Prominent clinician calls for action.

6 Apr 2006

New mechanism that initiates metastasis

Researchers have known for years that the enzyme MMP-9 plays a key role in the spread of colorectal cancer. Now, scientists at Jefferson Medical College in Philadelphia have found out how the enzyme helps initiate the process, known as metastasis.

4 Apr 2006

Discovery of a gene that drives anthrax bacteria's toxic effects

A study in Cell reports the discovery of a gene that drives anthrax bacteria's toxic effects. The gene could offer a potential new target for countermeasures against the lethal toxin, according to the researchers.

28 Mar 2006

Antibody may reduce or eliminate tumors

San Diego State University researcher Roger Sabbadini has brought scientists one step closer to finding a cure for cancer with the creation of an antibody that hinders the growth of tumors by preventing blood vessel formation.

17 Mar 2006

Capsaicin drives prostate cancer cells to kill themselves

Capsaicin, the stuff that turns up the heat in jalapeqos, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, according to studies published in the March 15 issue of Cancer Research.

15 Mar 2006

Scientists have gained valuable new insight into the biology of aggressive, incurable brain tumors

A research study published in the March issue of Cancer Cell uses gene expression profiling to identify molecular profiles and signaling pathways associated with tumor aggressiveness and disease progression.

15 Mar 2006

Lilly launches phase III trial of Enzastaurin

One of the deadliest and rarest forms of cancer is the focus of a Phase III study initiated by Eli Lilly and Company today.

9 Mar 2006

Fibulins inhibit both tumor growth and blood-vessel formation

Researchers at National Jewish Medical and Research Center report in the March issue of Cancer Research that a pair of promising proteins, known as fibulins 3 and 5, slow the growth of cancer tumors in mice by preventing blood vessels from sprouting. The proteins are promising candidates for use in cancer therapy.

1 Mar 2006

Study identifies compounds that overcome a specific type of resistance to chemotherapeutic-induced apoptosis

Treatment of human cancer is often impeded when cancer cells develop resistance to drugs that are designed to induce a type of programmed cell death called apoptosis.

16 Feb 2006

Nod1 found to control tumor growth in certain breast cancers

This protein was previously thought to play a role solely in the innate immune system's response to bacterial infection. In the new study, which will be published on-line by the Proceedings of the National Academy of Sciences

12 Feb 2006

Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast

Research in monkeys suggests that the natural plant estrogens found in soy do not increase markers of breast cancer risk in postmenopausal women. In fact, they may provide a protective effect in some women. The research is reported in Cancer Research.

16 Jan 2006

Gene discovery may prevent craniofacial birth defects

Craniofacial researchers have developed an animal model that explains how skull malformations occur and how they might be prevented.

22 Dec 2005

MicroRNAs greatly influence the evolution of genes

RNA continues to shed its reputation as DNA's faithful sidekick. Now, researchers in the lab of Whitehead Institute Member David Bartel have found that a class of small RNAs called microRNAs influence the evolution of genes far more widely than previous research had indicated.

7 Dec 2005

GRK5's role in restenosis

Researchers at Jefferson Medical College have begun to clarify the role of a protein - and potential drug target - in the process by which arteries re-clog after treatment.

28 Nov 2005

Study finds AKT blocks cancer cell motility

PIn investigating the molecular mechanisms of cancer cell motility - the unique property that enables cancer to spread from its primary origin to other parts of the body - researchers have uncovered a surprising role for the AKT/PKB (protein kinase B) enzyme

26 Nov 2005

Pretreating a vein graft with edifoligide prior to coronary bypass graft surgery does not lower the rate of graft failure

Coronary artery bypass graft (CABG) surgery is one of the most common surgical procedures performed in the United States, according to background information in the article. In appropriately selected patients, CABG surgery results in improved survival, relief of angina, and improved quality of life. Despite frequent use of artery grafts, vein grafts remain the most frequently used conduit.

13 Nov 2005

Zyflamend shows promise in the early treatment of prostate cancer

Data from the Columbia University Department of Urology demonstrates that Zyflamend, a unique herbal extract preparation, suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called "apoptosis."

13 Nov 2005