Cell Signaling News and Research

RSS

Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

New findings on brain tumors called ependymomas

Brain tumors called ependymomas that occur in different parts of the central nervous system appear to arise from subpopulations of stem cells called radial glia cells (RGCs), according to investigators at St. Jude Children's Research Hospital. The discovery explains why some identical-looking ependymomas are actually distinctly different diseases, the researchers said.

17 Oct 2005

Biologists uncover pivotal role of a gene called "Cut"

A DNA-binding protein, Cut interprets and transcribes the developmental signals sent through the "Notch" gene, which regulates a layer of epithelial cells as they replicate and divide. But when Cut garbles those signals the result is uncontrolled cell proliferation, sometimes with dire genetic and health consequences.

12 Oct 2005

Psychological stress during infancy has been found to cause early impaired memory

The study suggests that the emotional stress associated with parental loss, abuse or neglect may contribute to the type of memory loss during middle-age years that is normally seen in the elderly.

11 Oct 2005

Discovery of signaling component that influences spread of breast cancer cells

Researchers at the Virginia Commonwealth University Massey Cancer Center have found a new signaling component that influences movement of human breast cancer cells toward epidermal growth factor.

22 Aug 2005

Scientists show nuclear protein Ezh2 helps establish previously unknown signaling pathway in cells

Since 2001, scientists have wrestled with the discovery that there are fewer genes in humans than biological processes linked to those genes over the course of a human lifespan. One way to understand genetically coded events is by studying epigenetics, the regulation and heritability of genes at a cellular level due to molecular changes to the many proteins (called histones) that package DNA in a cell's nucleus.

23 May 2005

Research reveals atomic structure of angiopoietin-2, a key protein involved in the neo-vascularization of solid tumors

A structural biologist from the Virginia Commonwealth University Massey Cancer Center, in collaboration with researchers at Memorial Sloan-Kettering Cancer Center, has identified the crystal structure of a protein that plays a role in supplying nutrients to solid tumors.

11 May 2005

Scientists inhibit tumor formation

By studying mice with skin cancer, researchers at the Huntsman Cancer Institute at the University of Utah discovered a way to inhibit a mutant gene found in up to 30 percent of human tumors.

9 May 2005

Specific genes play key role in the of regulation of human-blood stem cells

This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.

2 May 2005

Being a party animal is good for you!

Scientists in the US say that being the life and soul of the party apart from being great fun could be good for the heart.

1 May 2005

P12 protein influences key cell-signaling pathway

New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body.

26 Apr 2005

With a complement, the sperm gets the egg

When a sperm fuses with an egg, a specific reaction takes place that exposes the inner membrane of the spermatozoa, where a protein called the complement regulator membrane cofactor protein (MCP) is expressed. MCP is an immune regulatory molecule and its presence in reproductive tissues was unclear.

21 Apr 2005

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancers of the prostate, breast, colon, ovary, pancreas, brain and blood, and reduce tumors in three animal studies, new research shows.

19 Apr 2005

Statins help cut risk for advanced prostate cancer

In a 10-year study of more than 30,000 health professionals, researchers at Johns Hopkins and Harvard found that the longer men take cholesterol-lowering drugs such as statins, the far less likely they are to develop advanced prostate cancer.

19 Apr 2005

Study suggests combination therapy could stop spread, halt growth of melanomas

Researchers at Penn State College of Medicine have identified the mechanism by which the most mutated gene in melanoma, called v599EB-Raf, aids melanoma tumor development demonstrating its importance as a therapeutic target.

22 Mar 2005

Q. What turns an obese person into a person with diabetes? - A. Leptin

Twin epidemics of obesity and type 2 diabetes are bearing down on the world's population, threatening the lives of hundreds of millions of people. But scientists are still trying to determine how the two conditions are linked, and what it takes to turn an obese person into a person with diabetes.

16 Mar 2005

Starpharma launches new start-up biotechnology company

Starpharma Holdings Limited today announced the establishment of a start-up biotechnology company (as a foundation shareholder).

15 Mar 2005

alpha-defensin-1, a protein found in immune cells, can control HIV infection

Theresa Chang and colleagues at Mount Sinai School of Medicine analyzed how alpha-defensin-1 inhibits HIV infection in white blood cells (CD4+ T cells). Defensins have been shown to have anti-HIV activity. The body attempts to protect itself from HIV infection via the innate immune system.

1 Mar 2005

U.S. cancer researchers launch first American-Israeli cancer conference

Leading cancer researchers from Baltimore, Miami and New Jersey have organized the first Joint American-Israeli Conference on Cancer. The meeting, scheduled for March 16 through 18 in Jerusalem, seeks to foster collaboration among physicians and scientists in the two countries.

1 Mar 2005

Scientists gain new insight into DiGeorge syndrome

A collaboration of European scientists has uncovered new insight into the most common chromosomal microdeletion syndrome in humans.

28 Feb 2005

Evaluation of BAY 43-9006 (Sorafenib) for pancreatic cancer

Oncologists from USC/Norris Comprehensive Cancer Center are running tests on a new pancreatic cancer drug that targets the cancer from two directions.

13 Jan 2005