Central Nervous System News and Research

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First UK real-world study shows promise for sacituzumab govitecan in metastatic breast cancer

The real-world safety and efficacy of sacituzumab govitecan (SG) against metastatic triple-negative breast cancer.

26 Apr 2024

Exploring the potential of ketogenic diets in managing epilepsy

The mechanisms of action, efficacy, and side effects of ketogenic diet (KD) variations in epileptic patients.

26 Apr 2024

Diet's impact on gut bacteria offers new clues in Parkinson's disease management

Researchers find that diet significantly influences the gut microbiome in Parkinson's disease patients, potentially affecting disease progression and symptoms.

25 Apr 2024

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine announces that it has received approval from the U.S. Food and Drug Administration for its Investigational New Drug application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of MTAP deleted cancers designed with Insilico's generative AI platform.

25 Apr 2024

$4.8 million grant supports research on TDP-43 misfolding in neurodegenerative diseases

A new $4.8 million grant will support researchers from Indiana University School of Medicine and the Medical Research Council Laboratory of Molecular Biology to study how human neurodegenerative diseases are affected by the misfolding of the protein TDP-43.

23 Apr 2024

Top pharmaceutical company evaluates Optimer for precision liver medicine

Optimer delivery vehicle has been shipped to a pharma partner for external evaluation.

From Aptamer Group 22 Apr 2024

New platform can deliver gene therapy precisely to specific areas of the brain

A novel approach to gene therapy is improving lives in ways once thought impossible. Researchers at The Ohio State University Wexner Medical Center and College of Medicine have developed a new platform to deliver the gene therapy precisely to specific areas of the brain.

18 Apr 2024

Exploring the versatile roles of tissue macrophages beyond immune defense

The role of resident tissue macrophages (RTMs) in homeostasis and disease.

17 Apr 2024

Study reveals how aberrant epigenetic regulation contributes to aggressive pediatric brain tumors

A new study conducted by researchers at Tampere University and Tampere University Hospital revealed how aberrant epigenetic regulation contributes to the development of atypical teratoid/rhabdoid (AT/RT) tumors, which are aggressive brain tumors that mainly affect young children.

15 Apr 2024

Proteasomes: Expanding roles beyond cellular waste management

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts.

13 Apr 2024

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances.

13 Apr 2024

Deciphering cancer plasticity:Insights from MSK research

About 90% of deaths from cancer are a result of metastasis -; that is, from cancer's ability to spread from an initial primary tumor to seed new tumors throughout the body, often in the lungs, liver, and brain.

10 Apr 2024

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024