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PARP enzymes can bring two broken DNA ends together, shows study

Scientists at St. Jude Children's Research Hospital have identified the structure of double-strand DNA break repair by PARP enzymes. The findings show that PARP2 can bridge the gap, bringing two broken DNA ends together.

16 Sep 2020

Study shows how mutations in DNA packaging machines can drive cancer development

Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins.

7 Sep 2020

Scientists aim to find cortisone alternatives with fewer side effects

Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19.

2 Sep 2020

Advances in Virus Epigenetics

Growing evidence shows viruses exploit epigenetic processes to control their life cycles but epigentic regulation of viral infections is not fully understood.

From Chromatrap® - Porvair Sciences Ltd 25 Aug 2020

Neutrolis announces development of first-in-class therapy to target NETs in COVID-19 patients

Neutrolis, a biotechnology company developing therapeutics that target neutrophils, the most abundant immune cells in the body, today announced the development of NTR-441, a first-in-class DNASE1L3 enzyme analog that has the potential to rapidly and systemically clear neutrophil extracellular traps for severe cases of COVID-19.

5 Aug 2020

Genetic variation influencing chromatin states associated with neuropsychiatric disorders

A new study led by NorthShore University HealthSystem and the University of Chicago took a novel approach to identifying SNPs influencing the risk of neuropsychiatric disorders like schizophrenia, bipolar and major depressive disorder, the institutions announced today.

4 Aug 2020

Antioxidants in diet could raise risk of bowel cancer, new study reveals

Health benefits of antioxidants in food have been proven across a considerable body of scientific literature. Now, a new study shows that too much of a good thing may not be that good! Typically antioxidants in food, including polyphenols, flavonoids, and other plant compounds, could raise the risk of bowel cancer finds a new study from Israeli researchers.

30 Jul 2020

UC San Diego researchers part of special package of human genome studies

Researchers at University of California San Diego School of Medicine are among the contributors to a package of 10 studies, published July 29, 2020 in the journal Nature, describing the latest results from the ongoing Encyclopedia of DNA Elements (ENCODE) project, a worldwide effort led by the National Institutes of Health to understand how the human genome functions.

29 Jul 2020

New maps of chemical marks on DNA could help illuminate the causes of developmental disorders

In research that aims to illuminate the causes of human developmental disorders, Salk scientists have generated 168 new maps of chemical marks on strands of DNA--called methylation--in developing mice.

29 Jul 2020

Study reveals multiple characteristics of HIV-1-producing cells in vivo

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo.

29 Jul 2020

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

The Epstein-Barr virus (EBV), one of the most common human viruses, is associated with about 8-10 per cent of stomach -- or gastric -- cancers, the third leading cause of cancer death globally.

27 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

Chromatin News and Research

PARP enzymes can bring two broken DNA ends together, shows study

Study shows how mutations in DNA packaging machines can drive cancer development

Scientists aim to find cortisone alternatives with fewer side effects

Advances in Virus Epigenetics

Neutrolis announces development of first-in-class therapy to target NETs in COVID-19 patients

Genetic variation influencing chromatin states associated with neuropsychiatric disorders

Antioxidants in diet could raise risk of bowel cancer, new study reveals

UC San Diego researchers part of special package of human genome studies

New maps of chemical marks on DNA could help illuminate the causes of developmental disorders

Study reveals multiple characteristics of HIV-1-producing cells in vivo

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

Epigenomic modifications play key role in the development of lung tumors

Researchers investigate the genetic and molecular basis of PD-L2 regulation

Researchers identify underlying mechanism for metabolic memory and diabetic complications

Researchers develop novel tool to maximize the power of deep learning for genomic studies

Researchers map non-coding, 'functional' genome in maize during early reproductive development

New technique to sort out complex interactions unique to prostate cancer cells

New strategies can help increase the efficiency of artificial cell reprogramming

UCLA scientists identify new function for histones

A data-rich atlas of the developing human brain

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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