Chromatin News and Research

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Genomic DNA provides clues to new advances in cancer diagnostics

Researchers at the University of Illinois at Chicago have identified a method of assessing the malignant potential of cells based on the sensitivity of cellular DNA to enzyme digestion.

22 Mar 2005

DLX5 gene may play a role in the pathology of Rett Syndrome

A research team led by Terumi Kohwi-Shigematsu of the Life Sciences Division of Lawrence Berkeley National Laboratory has identified a gene, DLX5, that may play a role in the pathology of Rett Syndrome, a devastating neurological disorder diagnosed almost exclusively in girls.

20 Dec 2004

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

Sometime between the age of 6 and 18 months, after a period of seemingly normal development, girls affected with Rett Syndrome lose interest in play; they gradually become withdrawn and anxious, develop autistic-like behaviors, and acquire specific symptoms like repetitive teeth-grinding and hand-wringing.

20 Dec 2004

Sensor protein that identifies DNA breaks and activates the p53 cell-death program has been identified

DNA breaks from radiation, toxic chemicals, or other environmental causes occur routinely in cells and, unless promptly and properly repaired, can lead to cancer-causing mutations.

4 Nov 2004

New view of chromatin and gene activity

A genome - the DNA instructions for an organism - does not act alone. DNA is packaged with proteins into 'chromatin', which may be more or less tightly condensed. A popular proposal is that active genes are in 'open' chromatin (to allow access to them) and inactive genes are in tightly packed 'compact' chromatin.

10 Sep 2004

Chromatin array a new technology for examining DNA

A new technique for examining DNA is giving scientists a more detailed picture of which genes have the propensity for activation, offering a new tool for understanding how genes function and possibly for diagnosing disease.

8 Jul 2004