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New spatial cell atlas of the developing human lung identifies 144 cell states

The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer.

8 Dec 2022

Early life experiences can affect gene activity more than half a lifetime later

Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers.

1 Dec 2022

Lysis and hypotonic sonication buffers for ChIP assays

Offering complete disruption of cytoplasmic and nuclear membranes, Porvair Sciences Chromatrap® buffer chemistries are optimised for sonication and enzymatic shearing.

From Porvair Sciences Limited 29 Nov 2022

UVA Health researchers develop new tool to advance genomics and disease research

UVA Health researchers have developed an important new tool to help scientists sort signal from noise as they probe the genetic causes of cancer and other diseases.

22 Nov 2022

Repetitive stress induces features of accelerated aging in the eye

New research from the University of California, Irvine, suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma patients.

21 Nov 2022

CLIMB method offers a more efficient way to uncover biologically meaningful changes in genomic data

A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions -; such as cell types or tissues.

14 Nov 2022

Study shows the importance of preserving microglia and Sirt1 functional efficiency for longevity

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 20, entitled, "Age-associated changes in microglia activation and Sirtuin-1- chromatin binding patterns."

11 Nov 2022

Protein complex may present strong therapeutic target for lethal breast cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that a protein complex that governs gene expression (called CoREST) sometimes gets rewired during breast cancer to help estrogen receptor positive (ER+) tumors resist endocrine therapies and become more aggressive.

8 Nov 2022

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19).

19 Oct 2022

NEI researchers create a high-resolution map of retinal cell chromatin contract points

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's nucleus.

7 Oct 2022

Histone mimicry by SARS-CoV-2 protein disrupts epigenetic regulation of host cells

Researchers demonstrated that the SARS-CoV-2 protein functions as a histone mimic to disrupt the epigenetic regulation of host cells.

7 Oct 2022

Intranasal vaccine represents an effective broad-spectrum COVID-19 vaccine strategy

Researchers evaluated the efficacy of dNS1-RBD, a novel intranasal COVID-19 vaccine.

6 Oct 2022

Pluripotent bat stem cells as a model to study novel viruses

Researchers generate induced pluripotent stem cells from bats using to establish bats as a novel in vivo model study species.

29 Sep 2022

A good night's sleep promotes immunity

In a recent study published in the Journal of Experimental Medicine, researchers in the United States used mice models to understand how sleep fragmentation affects immunological responses and the epigenetic modifications of hematopoietic stem and progenitor cells (HSPCs). They also conducted a sleep restriction trial in humans to determine HPSC programming and hematopoiesis.

25 Sep 2022

Scientists create new tool to identify genomic safe harbor sites in specific tissues

Scientists at St. Jude Children's Research Hospital have created a tool that can find safe places to introduce genes into human DNA.

22 Sep 2022

UCLA scientists receive $10 million to shed light on the developing brain's cellular infrastructure

Two scientists at the David Geffen School of Medicine at UCLA have been awarded nearly $10 million from the National Institutes of Health's Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative for research projects that aim to shed light on the developing brain's cellular infrastructure to better understand brain disorders.

22 Sep 2022

Chromatin News and Research

New spatial cell atlas of the developing human lung identifies 144 cell states

Early life experiences can affect gene activity more than half a lifetime later

Lysis and hypotonic sonication buffers for ChIP assays

UVA Health researchers develop new tool to advance genomics and disease research

Repetitive stress induces features of accelerated aging in the eye

CLIMB method offers a more efficient way to uncover biologically meaningful changes in genomic data

Study shows the importance of preserving microglia and Sirt1 functional efficiency for longevity

Protein complex may present strong therapeutic target for lethal breast cancer

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

NEI researchers create a high-resolution map of retinal cell chromatin contract points

Histone mimicry by SARS-CoV-2 protein disrupts epigenetic regulation of host cells

Intranasal vaccine represents an effective broad-spectrum COVID-19 vaccine strategy

Pluripotent bat stem cells as a model to study novel viruses

A good night's sleep promotes immunity

Scientists create new tool to identify genomic safe harbor sites in specific tissues

UCLA scientists receive $10 million to shed light on the developing brain's cellular infrastructure

Salk scientists launch a new Center for Multiomic Human Brain Cell Atlas with $126 million NIH grant

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

The effect of cannabis exposure on the entire sperm DNA methylome in rats

Animal models for studying the impacts of hormonal contraception

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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