Chromosome 22 News and Research

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Humans normally have 46 chromosomes (23 pairs) in each cell. Two copies of chromosome 22, one copy inherited from each parent, form one of the pairs. Chromosome 22 is the second smallest human chromosome, spanning about 50 million DNA building blocks (base pairs) and representing between 1.5 percent and 2 percent of the total DNA in cells.

In 1999, researchers working on the Human Genome Project announced they had determined the sequence of base pairs that make up this chromosome. Chromosome 22 was the first human chromosome to be fully sequenced.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 22 likely contains between 500 and 800 genes.

Genes on chromosome 22 are among the estimated 20,000 to 25,000 total genes in the human genome.
Einstein researcher receives $7.5 million NIH grant to study genetics of congenital heart disease

Einstein researcher receives $7.5 million NIH grant to study genetics of congenital heart disease

New mouse model reveals underlying brain changes linked to autism's social, learning problems

New mouse model reveals underlying brain changes linked to autism's social, learning problems

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Low birth weight, preterm birth increase schizophrenia risk in individuals with 22q11.2 deletion syndrome

Low birth weight, preterm birth increase schizophrenia risk in individuals with 22q11.2 deletion syndrome

Study: Growth hormone can improve social impairment in patients with Phelan-McDermid syndrome

Study: Growth hormone can improve social impairment in patients with Phelan-McDermid syndrome

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

Research findings may lead to new treatment strategies for Ewing sarcoma

Research findings may lead to new treatment strategies for Ewing sarcoma

Researchers explore gene expression in normal vestibular nerves, vestibular schwannomas

Researchers explore gene expression in normal vestibular nerves, vestibular schwannomas

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

Teva's SYNRIBO for injection receives FDA approval for home administration

Teva's SYNRIBO for injection receives FDA approval for home administration

Genetic evidence confirms role of group of virus-fighting genes in cancer development

Genetic evidence confirms role of group of virus-fighting genes in cancer development

Researchers identify gene variants that substantially increase risk for schizophrenia

Researchers identify gene variants that substantially increase risk for schizophrenia

FDA grants full approval of SYNRIBO for injection

FDA grants full approval of SYNRIBO for injection

Natera initiates distribution partnership with ProPath for Panorama non-invasive prenatal screening test

Natera initiates distribution partnership with ProPath for Panorama non-invasive prenatal screening test

Changes to LZTR1 gene predispose people to develop schwannomas

Changes to LZTR1 gene predispose people to develop schwannomas

‘Distinct’ bipolar pathways revealed

‘Distinct’ bipolar pathways revealed

Mechanism preserving genome integrity help develop new therapies against DiGeorge syndrome

Mechanism preserving genome integrity help develop new therapies against DiGeorge syndrome

CHOP’s 22q and You Center plays major role in brain and behavior consortium

CHOP’s 22q and You Center plays major role in brain and behavior consortium

Scientists find link between early-onset Parkinson's and 22q11.2 deletion syndrome

Scientists find link between early-onset Parkinson's and 22q11.2 deletion syndrome

Study shows ABL kinases have enhanced expression and activity in CML

Study shows ABL kinases have enhanced expression and activity in CML