Chromosome 22 News and Research

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Humans normally have 46 chromosomes (23 pairs) in each cell. Two copies of chromosome 22, one copy inherited from each parent, form one of the pairs. Chromosome 22 is the second smallest human chromosome, spanning about 50 million DNA building blocks (base pairs) and representing between 1.5 percent and 2 percent of the total DNA in cells.

In 1999, researchers working on the Human Genome Project announced they had determined the sequence of base pairs that make up this chromosome. Chromosome 22 was the first human chromosome to be fully sequenced.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 22 likely contains between 500 and 800 genes.

Genes on chromosome 22 are among the estimated 20,000 to 25,000 total genes in the human genome.
Scientists unravel mechanisms that lead to ventricular enlargement in schizophrenia

Scientists unravel mechanisms that lead to ventricular enlargement in schizophrenia

New study provides clear picture of brain abnormalities associated with schizophrenia

New study provides clear picture of brain abnormalities associated with schizophrenia

Study seeks participants with VCFS-related psychosis to help create biobank of cerebral organoids

Study seeks participants with VCFS-related psychosis to help create biobank of cerebral organoids

Researchers investigate how to prevent the onset of schizophrenia using mouse model

Researchers investigate how to prevent the onset of schizophrenia using mouse model

Researchers map uncharted area of genome using advanced imaging

Researchers map uncharted area of genome using advanced imaging

Research opens up new avenues for understanding the causes of schizophrenia

Research opens up new avenues for understanding the causes of schizophrenia

Children's Tumor Foundation establishes significant research initiative to combat NF2

Children's Tumor Foundation establishes significant research initiative to combat NF2

Study: Under-connectivity is the underlying cause of brain disorders

Study: Under-connectivity is the underlying cause of brain disorders

Zebrafish offers clue to alleviate gastrointestinal distress related to autism

Zebrafish offers clue to alleviate gastrointestinal distress related to autism

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

Abnormalities of blood vessels in the brain may play major role in development of schizophrenia

Abnormalities of blood vessels in the brain may play major role in development of schizophrenia

Scientists identify key gene in 22q11.2 that contributes to genitourinary birth defects

Scientists identify key gene in 22q11.2 that contributes to genitourinary birth defects

UCLA study characterizes brain differences between people with genetic risk for schizophrenia, autism

UCLA study characterizes brain differences between people with genetic risk for schizophrenia, autism

Study identifies potential Achilles heel of kinase-driven cancers

Study identifies potential Achilles heel of kinase-driven cancers

Scientists identify microrna that provides clues for quieting auditory hallucinations of schizophrenia

Scientists identify microrna that provides clues for quieting auditory hallucinations of schizophrenia

Einstein researcher receives $7.5 million NIH grant to study genetics of congenital heart disease

Einstein researcher receives $7.5 million NIH grant to study genetics of congenital heart disease

New mouse model reveals underlying brain changes linked to autism's social, learning problems

New mouse model reveals underlying brain changes linked to autism's social, learning problems

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Low birth weight, preterm birth increase schizophrenia risk in individuals with 22q11.2 deletion syndrome

Low birth weight, preterm birth increase schizophrenia risk in individuals with 22q11.2 deletion syndrome

Study: Growth hormone can improve social impairment in patients with Phelan-McDermid syndrome

Study: Growth hormone can improve social impairment in patients with Phelan-McDermid syndrome