Chromosome 22 News and Research

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Humans normally have 46 chromosomes (23 pairs) in each cell. Two copies of chromosome 22, one copy inherited from each parent, form one of the pairs. Chromosome 22 is the second smallest human chromosome, spanning about 50 million DNA building blocks (base pairs) and representing between 1.5 percent and 2 percent of the total DNA in cells.

In 1999, researchers working on the Human Genome Project announced they had determined the sequence of base pairs that make up this chromosome. Chromosome 22 was the first human chromosome to be fully sequenced.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 22 likely contains between 500 and 800 genes.

Genes on chromosome 22 are among the estimated 20,000 to 25,000 total genes in the human genome.
International Consortium receives grant to examine genetic reasons of schizophrenia in deletion syndrome patients

International Consortium receives grant to examine genetic reasons of schizophrenia in deletion syndrome patients

Study identifies gene variants associated with histological features of NAFLD

Study identifies gene variants associated with histological features of NAFLD

New insight into 22q11.2 deletion syndrome

New insight into 22q11.2 deletion syndrome

MOZ protein could explain variations in severity of DiGeorge syndrome

MOZ protein could explain variations in severity of DiGeorge syndrome

Associate director of Clinical Genetics receives Angelo DiGeorge Medal of Honor

Associate director of Clinical Genetics receives Angelo DiGeorge Medal of Honor

Researchers use maternal blood sample to sequence genome of an unborn baby

Researchers use maternal blood sample to sequence genome of an unborn baby

Genetic mutation that creates Ewing's sarcoma leads to high levels of protein EYA3

Genetic mutation that creates Ewing's sarcoma leads to high levels of protein EYA3

Clinical trial to evaluate IGF-1 in children with SHANK3 deficiency

Clinical trial to evaluate IGF-1 in children with SHANK3 deficiency

Chromosome aberrations happen in pairs when it comes to cancer

Chromosome aberrations happen in pairs when it comes to cancer

CHOP, Albert Einstein College of Medicine to study genetics of conotruncal defects

CHOP, Albert Einstein College of Medicine to study genetics of conotruncal defects

Two new research studies on schizophrenia

Two new research studies on schizophrenia

Research on BCR-ABL inhibitors for treating ALL, CML presented at ASH Annual Meeting

Research on BCR-ABL inhibitors for treating ALL, CML presented at ASH Annual Meeting

Fox Chase Cancer Center to host Philadelphia Chromosome Symposium

Fox Chase Cancer Center to host Philadelphia Chromosome Symposium

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Research confirms genetic link to advanced fatty liver disease

Research confirms genetic link to advanced fatty liver disease

Genetics research team discovers new recurrent translocations

Genetics research team discovers new recurrent translocations

Researchers discover genetic explanation for non-diabetic kidney disease in African-Americans

Researchers discover genetic explanation for non-diabetic kidney disease in African-Americans

Research sheds light on early embryogenesis, genetic disease

Research sheds light on early embryogenesis, genetic disease

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

Research sheds light on prenatal heart formation, chromosome 22q.11 deletion syndrome

New methodology helps investigate unfolding of DNA

New methodology helps investigate unfolding of DNA