Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.
Significant step forward in the genome era

Significant step forward in the genome era

Tourette syndrome linked to SLITRK1 gene

Tourette syndrome linked to SLITRK1 gene

PCBs found widely in the environment and absorbed in the diet - may damage sperm

PCBs found widely in the environment and absorbed in the diet - may damage sperm

First gene mutation associated with Tourette syndrome

First gene mutation associated with Tourette syndrome

Chromosomes in the nucleus of the cell carry the material of heredity, or genes

Chromosomes in the nucleus of the cell carry the material of heredity, or genes

Specific gene on chromosome 15 regulates inflammation

Specific gene on chromosome 15 regulates inflammation

Tissue engineering used to reconstruct defective tracheas (windpipes) in fetal lambs

Tissue engineering used to reconstruct defective tracheas (windpipes) in fetal lambs

New information regarding the genetic, cellular and neurological bases of susceptibility to autism and schizophrenia

New information regarding the genetic, cellular and neurological bases of susceptibility to autism and schizophrenia

Researchers identify gene defect in mice that causes cyclical hair loss and skin cancer

Researchers identify gene defect in mice that causes cyclical hair loss and skin cancer

Mechanism of X-chromosome dosage compensation in Drosophila

Mechanism of X-chromosome dosage compensation in Drosophila

Research on cartilage erosion and bone abnormalities

Research on cartilage erosion and bone abnormalities

Discovery establishes a role for the gene Rsf-1 in ovarian cancer

Discovery establishes a role for the gene Rsf-1 in ovarian cancer

Discovered of gene mutations associated with hereditary neuralgic amyotrophy

Discovered of gene mutations associated with hereditary neuralgic amyotrophy

Gene responsible for Neuralgic Amyotrophy identified

Gene responsible for Neuralgic Amyotrophy identified

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

Researchers map genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people

Mutations in the gene, called PIG-A may help identify individuals at high risk for cancer

Mutations in the gene, called PIG-A may help identify individuals at high risk for cancer

Definitive multiple sclerosis linkage screen

Definitive multiple sclerosis linkage screen

Gene mutation may increase the risk of prostate cancer up to three times in African-American

Gene mutation may increase the risk of prostate cancer up to three times in African-American

Suppression of FOXO1a gene might kill resistant alveolar rhabdomyosarcoma (ARMS) tumors

Suppression of FOXO1a gene might kill resistant alveolar rhabdomyosarcoma (ARMS) tumors

Acute-leukemia sign may signal need for different therapy

Acute-leukemia sign may signal need for different therapy

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