Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.
Genetically informed brain atlases help identify hundreds of genomic loci

Genetically informed brain atlases help identify hundreds of genomic loci

Genomes of marine invertebrates found to be surprisingly stable across deep time

Genomes of marine invertebrates found to be surprisingly stable across deep time

Using interdisciplinary approach to beat cancer

Using interdisciplinary approach to beat cancer

Study offers unprecedented insight into the mechanism of action of topo VI enzyme

Study offers unprecedented insight into the mechanism of action of topo VI enzyme

UofL professor wins $6.7 million grant to investigate how metals cause lung cancer

UofL professor wins $6.7 million grant to investigate how metals cause lung cancer

Low-cost test could open new avenues for earlier diagnosis, treatment of rare genetic disorders

Low-cost test could open new avenues for earlier diagnosis, treatment of rare genetic disorders

Exploring loss of Y chromosome in white blood cells as a risk-factor of life-threatening COVID-19 in men

Exploring loss of Y chromosome in white blood cells as a risk-factor of life-threatening COVID-19 in men

Researchers identify first known patients with BUB1 biallelic mutations

Researchers identify first known patients with BUB1 biallelic mutations

New method reverses insecticide resistance using CRISPR/Cas9 technology

New method reverses insecticide resistance using CRISPR/Cas9 technology

New pathways responsible for hepatocellular carcinoma identified

New pathways responsible for hepatocellular carcinoma identified

Overall survival rate has nearly doubled for Ph+ ALL patients after hematopoietic stem cell transplant

Overall survival rate has nearly doubled for Ph+ ALL patients after hematopoietic stem cell transplant

Scientists discover a division of labor between genetic switches

Scientists discover a division of labor between genetic switches

Deletion of autism-linked gene diminishes myelin in mice

Deletion of autism-linked gene diminishes myelin in mice

Study reveals chromosome-level changes that relate to drug resistance in melanoma

Study reveals chromosome-level changes that relate to drug resistance in melanoma

Correlation between idiopathic pulmonary fibrosis and COVID-19

Correlation between idiopathic pulmonary fibrosis and COVID-19

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

SARS-CoV-2 Delta saliva viral load 15 times that of the wild type

SARS-CoV-2 Delta saliva viral load 15 times that of the wild type

Researchers use gene-editing to create single sex mice litters

Researchers use gene-editing to create single sex mice litters

Mutations in a crucial gene responsible for chemotherapy failure in some blood cancer patients

Mutations in a crucial gene responsible for chemotherapy failure in some blood cancer patients

Telomeric DNA damage response may increase susceptibility of elderly people to COVID-19

Telomeric DNA damage response may increase susceptibility of elderly people to COVID-19

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