Chromosome Y News and Research

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The Y chromosome is one of the two sex chromosomes in humans (the other is the X chromosome). The sex chromosomes form one of the 23 pairs of human chromosomes in each cell. The Y chromosome spans about 58 million base pairs (the building blocks of DNA) and represents almost 2 percent of the total DNA in cells.

Each person normally has one pair of sex chromosomes in each cell. The Y chromosome is present in males, who have one X and one Y chromosome, while females have two X chromosomes.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. The Y chromosome likely contains between 70 and 200 genes. Because only males have the Y chromosome, the genes on this chromosome tend to be involved in male sex determination and development. Sex is determined by the SRY gene, which is responsible for the development of a fetus into a male. Other genes on the Y chromosome are important for male fertility.

Many genes are unique to the X or Y chromosome, but genes in an area known as the pseudoautosomal region are present on both chromosomes. As a result, men and women each have two functional copies of these genes. Many genes in the pseudoautosomal region are essential for normal development.

Genes on the Y chromosome are among the estimated 20,000 to 25,000 total genes in the human genome.
Exploring loss of Y chromosome in white blood cells as a risk-factor of life-threatening COVID-19 in men

Exploring loss of Y chromosome in white blood cells as a risk-factor of life-threatening COVID-19 in men

What does the future look like for bleeding disorders?

What does the future look like for bleeding disorders?

New study uncovers a mechanism of sleep in zebrafish

New study uncovers a mechanism of sleep in zebrafish

Study underscores why COVID-19 vaccine boosters are important for all adults

Study underscores why COVID-19 vaccine boosters are important for all adults

Researchers identify never-before-defined subtypes of a blood cancer

Researchers identify never-before-defined subtypes of a blood cancer

Scientists identify new gene that contributes to type 1 diabetes progression

Scientists identify new gene that contributes to type 1 diabetes progression

Scientists discover gene responsible for doubling the risk of respiratory failure from COVID-19

Scientists discover gene responsible for doubling the risk of respiratory failure from COVID-19

Identification of a candidate effector gene at COVID-19 risk locus

Identification of a candidate effector gene at COVID-19 risk locus

Chromosome aberrations linked to acute toxicities in esophageal cancer patients

Chromosome aberrations linked to acute toxicities in esophageal cancer patients

New application makes it possible to monitor the symptoms of people at risk for psychosis

New application makes it possible to monitor the symptoms of people at risk for psychosis

Rutgers study links genetic disorders to walking patterns

Rutgers study links genetic disorders to walking patterns

Research reveals the mechanisms of cardiac sex disparities at an early stage

Research reveals the mechanisms of cardiac sex disparities at an early stage

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

Famous scientist joins NYU Langone’s Division of Rheumatology

Famous scientist joins NYU Langone’s Division of Rheumatology

Devastating genetic disease in children may be treatable in adulthood

Devastating genetic disease in children may be treatable in adulthood

Qatar genomics study reveals key historical and social insights into Arab populations

Qatar genomics study reveals key historical and social insights into Arab populations

New metagenome assembler can generate accurate DNA sequences

New metagenome assembler can generate accurate DNA sequences

NIH awards more than $8 million to support seven high-risk, high-reward projects at Penn Medicine

NIH awards more than $8 million to support seven high-risk, high-reward projects at Penn Medicine

New Maternal and Child Health Research Institute launched to improve national health in Singapore

New Maternal and Child Health Research Institute launched to improve national health in Singapore