Chromosome Y News and Research

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The Y chromosome is one of the two sex chromosomes in humans (the other is the X chromosome). The sex chromosomes form one of the 23 pairs of human chromosomes in each cell. The Y chromosome spans about 58 million base pairs (the building blocks of DNA) and represents almost 2 percent of the total DNA in cells.

Each person normally has one pair of sex chromosomes in each cell. The Y chromosome is present in males, who have one X and one Y chromosome, while females have two X chromosomes.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. The Y chromosome likely contains between 70 and 200 genes. Because only males have the Y chromosome, the genes on this chromosome tend to be involved in male sex determination and development. Sex is determined by the SRY gene, which is responsible for the development of a fetus into a male. Other genes on the Y chromosome are important for male fertility.

Many genes are unique to the X or Y chromosome, but genes in an area known as the pseudoautosomal region are present on both chromosomes. As a result, men and women each have two functional copies of these genes. Many genes in the pseudoautosomal region are essential for normal development.

Genes on the Y chromosome are among the estimated 20,000 to 25,000 total genes in the human genome.

Discovery of eight previously unknown genes that affect blood pressure

Eight previously unknown genes that affect blood pressure were recently identified in a comprehensive international study comprising 34,433 Europeans. The findings of the study, in which Uppsala University researchers participated, are being presented in the Web edition of Nature Genetics.

11 May 2009

New DEAR1 gene predicts local recurrence in early-onset breast cancer

A newly discovered gene known as DEAR1 is mutated in breast cancer and is an independent predictor of local recurrence-free survival in early-onset breast cancer, a research team headed by scientists at The University of Texas M. D. Anderson Cancer Center reports in the journal PLoS Medicine.

5 May 2009

New gene called DEAR1 may be a breast cancer diagnostic marker

In a research article published in this week's PLoS Medicine, Ann Killary (from the University of Texas M. D. Anderson Cancer Center) and colleagues describe a new gene called DEAR1 that is genetically altered by mutation and deletion in breast tumors, and that may provide a new breast cancer prognostic marker.

4 May 2009

CDH10 gene found to play a critical role in prenatal risk of autism

UCLA scientists, in partnership with 30 research institutions across the country, have identified a new gene variant that is highly common in autistic children.

30 Apr 2009

Genes that influence brain cell connections linked to autism

In three studies, including the most comprehensive study of autism genetics to date, investigators funded in part by the National Institutes of Health have identified common and rare genetic factors that affect the risk of autism spectrum disorders.

30 Apr 2009

Gene alterations associated with response to anthracycline therapy for breast cancer

Alterations in the topoisomerase II alpha (TOP2A) gene were associated with better patient outcomes following anthracycline-based therapy compared with non-anthracycline-based regimens, according to a study in the April 28 online issue of the Journal of the National Cancer Institute.

30 Apr 2009

Discovery of gene region that may account for as many as 15 percent of autism cases

A research team has connected more of the intricate pieces of the autism puzzle, with two studies that identify genes with important contributions to the disorder.

30 Apr 2009

Discovery of genetic link for pelvic floor disorders

University of Utah researchers have identified a region of the human genome that may contribute to the development of pelvic floor disorders such as pelvic organ prolapse and stress urinary incontinence, according to a study published this week in the American Journal of Human Genetics .

23 Apr 2009

Research finds gene bringing together animal and human research in alcoholism

An important genetic study conducted through Mayo Clinic has identified vital new information concerning alcoholism in subjects with European ancestry, according to a recent issue of Alcohol: Clinical and Experimental Research.

23 Apr 2009

Discovery shows that different parts of chromosomes can have very different evolutionary histories

A new study reveals that - contrary to decades of evolutionary thought - chromosome regions that are prone to breakage when new species are formed are a rich source of genetic variation.

23 Apr 2009

Discovery of common genetic variation associated with colorectal cancer

Genetics plays a key role in determining risk for colorectal cancer, the second leading cause of cancer-related deaths in the United States.

23 Apr 2009

Common gene variant linked to development of prostate cancer

Researchers have described how a common genetic variation may be involved in the development of prostate cancer.

22 Apr 2009

Discovery of genetic pattern that may predict response to Gleevec in GIST

Researchers at Fox Chase Cancer Center uncovered a genetic pattern that may help predict how gastrointestinal stromal tumor (GIST) patients respond to the targeted therapy imatinib mesylate (Gleevec).

22 Apr 2009

Mouse model provides a new tool for investigating Wolf-Hirschhorn syndrome

Wolf-Hirschhorn Syndrome (WHS) is a human disease caused by spontaneous genetic deletions.

22 Apr 2009

Another gene found for Rett syndrome

New research has revealed another gene for Rett syndrome which could lead to new treatments for the disorder.

22 Apr 2009

Discovery of nine new genes on X chromosome that, when knocked-out, lead to learning disabilities

The international team studied almost all X chromosome genes in 208 families with learning disabilities - the largest screen of this type ever reported.

20 Apr 2009

Move over, Y chromosome - it's time X got some attention

In the first evolutionary study of the chromosome associated with being female, University of California, Berkeley, biologist Doris Bachtrog and her colleagues show that the history of the X chromosome is every bit as interesting as the much-studied, male-determining Y chromosome, and offers important clues to the origins and benefits of sexual reproduction.

16 Apr 2009

Discovery of gene variation linked to increased risk of ischemic stroke

Millions of people have a genetic variant linked to increased risk of ischemic stroke, reports an international research team including scientists at The University of Texas Health Science Center at Houston in a study published online by The New England Journal of Medicine on April 15.

15 Apr 2009