Citric Acid Cycle News and Research

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New technique to hyperpolarize and purify fumarate for MRI

A promising new concept published by an interdisciplinary research team in "Proceedings of the National Academy of Sciences" (PNAS) paves the way for major advances in the field of magnetic resonance imaging (MRI). Their new technique could significantly simplify hyperpolarized MRI, which developed around 20 years ago for observing metabolic processes in the body.

28 Apr 2021

Light-activated protein restores mitochondrion function in fruit fly model of Parkinson’s disease

A light-sensitive protein can restore mitochondria function in fruit flies bearing a gene mutation associated with Parkinson’s disease and relieve its symptoms, report researchers at Juntendo University in the journal Communications Biology.

13 Feb 2020

New protein target for deadly ovarian cancer

A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract.

14 Jul 2019

How pathogens are controlled under hypoxic conditions

Infected tissue has a low concentration of oxygen. The body's standard immune mechanisms, which rely on oxygen, can then only function to a limited extent.

24 May 2019

Fasting may boost human metabolic activity, research suggests

Fasting may help people lose weight, but new research suggests going without food may also boost human metabolic activity, generate antioxidants, and help reverse some effects of aging.

31 Jan 2019

Research finds decline in ketone body utilization when coronary circulation is reduced

Ketone bodies are metabolites that can be used as energy sources like glucose and fatty acids. They can be converted into acetyl-CoA, which produces energy via the Krebs cycle in the mitochondria, and are typically used as an alternative energy source during starvation, fasting, or periods of high-intensity exercise.

17 Jan 2019

Protein profiling reveals new prostate cancer mechanisms

A study by the University of Tampere in Finland used protein profiling to find new prostate cancer mechanisms that are not shown by aberrations at the genomic level. Several new potential biomarkers of prostate cancer were also found.

21 Mar 2018

Zinc-binding plays key role in sensing and regulation of brain’s pH levels

Researchers in Oslo, Norway, have discovered that Zinc-binding plays an important role in the sensing and regulation of pH in the human brain. The findings come as one of the first studies that directly link Zinc-binding with bicarbonate transporters.

17 Oct 2017

Oral antidiabetic drug modulates the body's nitrogen and urea metabolism

The most frequently prescribed oral antidiabetic drug metformin significantly affects metabolic pathways.

14 Sep 2016

Researchers disprove previously assumed behavior of macrophage immune cells

What happens when macrophage immune cells are activated in the course of an inflammation to combat pathogens such as bacteria or viruses? Researchers of the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg pursued this very question. The researchers discovered that the immune cells behave differently from what was previously assumed. Their metabolism upholds the production of antimicrobial substances and fatty acids during activation. In this way, they deliver important resources for the immune responses they trigger.

21 Mar 2016

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.

4 Mar 2016

Researcher discover new chemical class that attacks two key cancer cell building block targets

Imagine cutting down the growth of cancer cells at their earliest stages to halt tumor growth. Research conducted by leading cancer metabolism researchers at Stony Brook University, Paul M. Bingham, PhD, and Zuzana Zachar, PhD, is showing promise in this approach with their clinical investigation of a new class of compounds that disrupt cancer cell mitochondrial metabolism.

14 Mar 2014

Shifts in zinc's location could be exploited for early diagnosis of prostate cancer

Zinc, an essential nutrient, is found in every tissue in the body. The vast majority of the metal ion is tightly bound to proteins, helping them to perform biological reactions. Tiny amounts of zinc, however, are only loosely bound, or "mobile," and thought to be critical for proper function in organs such as the brain, pancreas, and prostate gland. Yet the exact roles the ion plays in biological systems are unknown.

9 Dec 2013

Gastrointestinal, liver effects common after doxycycline in cats

Doxycycline, an antibiotic derivative of tetracycline, commonly results in adverse gastrointestinal side effects and increased liver enzyme activity in cats, report German researchers.

25 Jan 2013

Bionovo to present phase 1B trial results of BZL101 in metastatic breast cancer

Bionovo, Inc. has announced the company will present results from the Phase 1B clinical trial of their lead drug candidate for advanced metastatic breast cancer, BZL101, at the Society for Integrative Oncology's Fifth International Conference in Atlanta, Georgia.

20 Nov 2008