Clinical Trial News and Research

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Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the Neurology Service at the same hospital, have found that over 95% of individuals over 65 years old who have two copies of the APOE4 gene -APOE4 homozygotes- show biological characteristics of Alzheimer's pathology in the brain or biomarkers of this disease in cerebrospinal fluid and PET scans.

6 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

Genomics plc and GSK announced a new collaboration to explore the potential for using polygenic risk scores (PRS) in clinical trials, to improve understanding of disease risk and patient selection, which could support optimization of trial design.

6 May 2024

NK cells' role in cancer therapy resistance unveiled

Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system.

3 May 2024

Study supports the consideration of 177Lu-PSMA-617 as new standard treatment for metastatic prostate cancer

In a follow-on analysis of results from the phase 3 PSMAfore study, clinical investigators from Dana-Farber and elsewhere found that clinical outcomes consistently favored 177Lu-PSMA-617 over a change from one androgen receptor pathway inhibitor (ARPI) to another, regardless of which ARPI patients received first.

3 May 2024

Investigating fertilized ACL surgery's impact on return to play in athletes

The Marshall University Joan C. Edwards School of Medicine is now accepting applicants for an observational trial focused on fertilized anterior cruciate ligament (ACL) reconstruction.

2 May 2024

AI model mimics randomized clinical trials for determining optimal stroke prevention treatment

Scientists have designed a new artificial intelligence model that emulates randomized clinical trials at determining the treatment options most effective at preventing stroke in people with heart disease.

2 May 2024

Study reveals molecular changes in 19 organs due to exercise

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought.

2 May 2024

First FDA-approved cellular therapy for metastatic melanoma available in South Florida

Patients in South Florida with metastatic melanoma will soon have access to the first cellular therapy for this advanced form of skin cancer, following its recent approval by the Food and Drug Administration (FDA).

2 May 2024

Study reveals survival benefit from genome-matched cancer treatments in rural Maine

In 2016, The Jackson Laboratory (JAX), a National Cancer Institute-designated Cancer Center and at the forefront of cancer research, launched the Maine Cancer Genomics Initiative (MCGI) to bring the latest progress in cancer care to rural Maine patients.

1 May 2024

AI-enabled ECG system significantly reduces hospital mortality rates by identifying at-risk patients

A study in Nature Medicine evaluated an AI-enabled electrocardiogram (ECG) system's ability to identify hospitalized patients at risk of death, demonstrating its effectiveness in reducing mortality by enhancing the rapid response systems (RRS) through real-time alerts and risk stratification.

30 Apr 2024

Garvan Institute and Illumina collaborate to transform the treatment of complex diseases

Illumina, a global genomics and human health company, has partnered with the Garvan Institute of Medical Research's TenK10K project to help transform the treatment of complex diseases, starting with autoimmune diseases, with a joint investment of $27 million AUD.

30 Apr 2024

New monoclonal antibody vaccine slashes malaria risk in children

A recent study demonstrates that the monoclonal antibody-based vaccine L9LS is safe for children aged 6 to 10 and significantly reduces the risk of malaria infection and clinical symptoms by 70% and 77%, respectively.

30 Apr 2024

Deciphering the role of Th2-multipotent progenitor cells in chronic allergic inflammation

Currently, most therapies for allergic diseases require lifelong treatment. Allergic reactions, characterized by ongoing (type 2) inflammation in response to chronic antigen exposure, underlie many chronic diseases in humans, including asthma, atopic dermatitis, ulcerative colitis and more.

30 Apr 2024

Measles and rubella vaccine delivered via microarray patch shows promising results

The phase 1/2 randomized trial compared results from the measles and rubella vaccine delivered by a microarray patch, a small sticking plaster-like device with an array of microscopic projections that painlessly penetrate the skin and deliver the vaccine, or by conventional injection with a needle and syringe.

29 Apr 2024

STRONG STAR Consortium awarded $17M for traumatic brain injury and psychological health research

In a recent round of grant awards, the STRONG STAR Consortium based at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) was selected by the U.S. Department of Defense for a total of $17 million in funding to launch eight new research projects focused on traumatic brain injury and psychological health.

29 Apr 2024

Georgetown study raises concerns over aspirin's role in breast cancer treatment

A new study examining the role of aspirin in breast cancer treatment reveals critical issues related to health equity and aging that have broad implications for cancer and other disease intervention trials, say researchers from Georgetown University's Lombardi Comprehensive Cancer Center.

29 Apr 2024

Assessing newborn nursing mechanics with modified pacifier technology and AI algorithms

A modified pacifier and AI algorithms to analyze the data it produces could determine if newborns are learning the proper mechanics of nursing, a recent study shows.

29 Apr 2024

Study reveals how genetic changes in SCN2A gene impact autism and epilepsy

A genetic change or variant in a gene called SCN2A is a known cause of infantile seizures, autism spectrum disorder and intellectual disability, as well as a wide range of other moderate-to-profound impairments in mobility, communication, eating and vision.

26 Apr 2024

Single dose of malaria monoclonal antibody 77% effective in children, trial in Mali shows

One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country's six-month malaria season, according to the results of a mid-stage clinical trial.

26 Apr 2024

Clinical Trial News and Research

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Durable lymph-node expansion improves vaccine responses against tumors

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

NK cells' role in cancer therapy resistance unveiled

Study supports the consideration of 177Lu-PSMA-617 as new standard treatment for metastatic prostate cancer

Investigating fertilized ACL surgery's impact on return to play in athletes

AI model mimics randomized clinical trials for determining optimal stroke prevention treatment

Study reveals molecular changes in 19 organs due to exercise

First FDA-approved cellular therapy for metastatic melanoma available in South Florida

Study reveals survival benefit from genome-matched cancer treatments in rural Maine

AI-enabled ECG system significantly reduces hospital mortality rates by identifying at-risk patients

Garvan Institute and Illumina collaborate to transform the treatment of complex diseases

New monoclonal antibody vaccine slashes malaria risk in children

Deciphering the role of Th2-multipotent progenitor cells in chronic allergic inflammation

Measles and rubella vaccine delivered via microarray patch shows promising results

STRONG STAR Consortium awarded $17M for traumatic brain injury and psychological health research

Georgetown study raises concerns over aspirin's role in breast cancer treatment

Assessing newborn nursing mechanics with modified pacifier technology and AI algorithms

Study reveals how genetic changes in SCN2A gene impact autism and epilepsy

Single dose of malaria monoclonal antibody 77% effective in children, trial in Mali shows

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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