Cocaine dependence (or addiction) is physical and psychological dependency on the regular use of cocaine. It can result in severe physiological damage, psychosis, schizophrenia, lethargy, depression, or a potentially fatal overdose.
Rochelle Schwartz-Bloom, a Duke University pharmacology professor who left the lab bench to focus on science education, has developed a tactic for keeping students hands in the air at the end of class.
Catalyst Pharmaceutical Partners, Inc. a specialty pharmaceutical company that acquires or in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced that it has initiated its randomized, double-blind, placebo-controlled U.S. Phase II clinical trial of CPP-109 in patients with cocaine dependence.
People addicted to cocaine have an impaired ability to perceive rewards and exercise control due to disruptions in the brain's reward and control circuits, according to a series of brain-mapping studies and neuropsychological tests conducted at the U.S. Department of Energy's Brookhaven National Laboratory.
Ask anyone who has been addicted to drugs and they'll tell you that the mere sight of someone using their drug of choice - or even people, places, or objects associated with drug use - can trigger an intense desire for the drug.
An editorial in the January 2006 issue of the Psychiatric Bulletin reviews the evidence for the effectiveness of gene-based smoking cessation packages, and asks whether they are appropriate for psychiatric patients.
Cocaine causes specific alterations in the brain's circuitry at a genetic level, including short-term changes that result in a high from the cocaine, as well as long-term changes seen in addiction, researchers from UT Southwestern Medical Center have found.
Researchers are now understanding in greater detail the molecular machinery underlying the short-term brain changes that produce the high of cocaine, as well as the longer-term changes behind addiction. Their findings offer hope for targeted drugs that can short-circuit that addiction machinery.
Cocaine dependence is a major public health problem affecting thousands of people around the globe. Despite years of active research there are still no approved medications for the treatment of this life-shattering addiction.
A new study builds on previous research showing that cocaine-addicted people have a low expression of specific dopamine receptors—D2 receptors—in a portion of the brain called the striatum.
Scientists at The Scripps Research Institute have designed a potentially valuable tool for treating cocaine addiction by creating a modified "phage" virus that soaks up the drug inside the brain.
Researchers at the Yerkes National Primate Research Center are the first to demonstrate that a combination of drug therapies targeting the region of the brain that controls drug abuse and addiction significantly reduces cocaine use in nonhuman primates.
Xenova Group plc has announced the presentation of results of two dose escalation Phase II studies of TA-CD, a vaccine being developed for the treatment of cocaine addiction, at the College on Problems of Drug Dependence 66th Annual Scientific Meeting in Puerto Rico, June 12-17.
Researchers at the Yerkes National Primate Research Center of Emory University are the first to demonstrate a combination of drug therapies targeting the region of the brain that controls drug abuse and addiction significantly reduces cocaine use in nonhuman primates.